8SYC
Crystal structure of PDE3B in complex with GSK4394835A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | polymer | 443 | 51054.5 | 2 | UniProt (Q13370) Pfam (PF00233) In PDB | Homo sapiens (human) | CGIPDE1,CGIP1,Cyclic GMP-inhibited phosphodiesterase B,CGI-PDE B |
2 | A, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
3 | A, D | [3-[(4,7-dimethoxyquinolin-2-yl)carbonylamino]-5-[methyl-(phenylmethyl)carbamoyl]phenyl]-oxidanyl-oxidanylidene-boron | non-polymer | 498.3 | 2 | Chemie (X5W) | |||
4 | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, D: 654 - 1074 (UniProt: Q13370)
PDB | External Database | Details |
---|---|---|
Met 653 | - | initiating methionine |
Asp 691 | Lys 691 | engineered mutation |
Asp 783 | Arg 783 | engineered mutation |
Glu 831 | Ala 831 | engineered mutation |
Glu 880 | Lys 880 | engineered mutation |
Asp 981 | Ser 981 | engineered mutation |
Asn 1075 | - | expression tag |
Leu 1076 | - | expression tag |
Tyr 1077 | - | expression tag |
Phe 1078 | - | expression tag |
Gln 1079 | - | expression tag |
Gly 1080 | - | expression tag |
Asp 1081 | - | expression tag |
Tyr 1082 | - | expression tag |
Lys 1083 | - | expression tag |
Asp 1084 | - | expression tag |
Asp 1085 | - | expression tag |
Asp 1086 | - | expression tag |
Asp 1087 | - | expression tag |
Lys 1088 | - | expression tag |
Gly 1089 | - | expression tag |
His 1090 | - | expression tag |
His 1091 | - | expression tag |
His 1092 | - | expression tag |
His 1093 | - | expression tag |
His 1094 | - | expression tag |
His 1095 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 102109.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1093.8 | |
All* | Total formula weight | 103202.9 |