8SYC
Crystal structure of PDE3B in complex with GSK4394835A
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDYdHpGrtNeF |
| Chain | Residue | Details |
| A | HIS821-PHE832 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083 |
| Chain | Residue | Details |
| A | HIS737 | |
| D | HIS737 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q14432 |
| Chain | Residue | Details |
| A | HIS737 | |
| A | GLN988 | |
| D | HIS737 | |
| D | GLN988 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15147193, ECO:0007744|PDB:1SO2, ECO:0007744|PDB:1SOJ |
| Chain | Residue | Details |
| A | HIS741 | |
| A | HIS821 | |
| A | ASP937 | |
| D | HIS741 | |
| D | HIS821 | |
| D | ASP937 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15147193, ECO:0007744|PDB:1SO2 |
| Chain | Residue | Details |
| A | ASP822 | |
| D | ASP822 |
