8SKN

Crystal structure of compound 3-bound human Dynamin-1-like protein GTPase-BSE fusion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dynamin-1-like protein GTPase-BSE fusion	polymer	382	42559.7	2	UniProt (D3DUW7) Pfam (PF00350) Pfam (PF01031) UniProt (by SIFTS) (O00429)	Homo sapiens (human)
2	C (A)	N-[4-(azetidin-1-yl)-2-(4-methylphenyl)quinolin-6-yl]-2-methylpropanamide	non-polymer		359.5	1	Chemie (6I9)
3	D, E, F, G, H... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
4	O, P (A, B)	water	water		18.0	158	Chemie (HOH)

Sequence modifications

A, B: 1 - 703 (UniProt: D3DUW7)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

A, B: 709 - 736 (UniProt: D3DUW7)

PDB	External Database	Details
His 704	-	linker
Gly 705	-	linker
Thr 706	-	linker
Asp 707	-	linker
Ser 708	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85119.3
Non-Polymers*	Number of molecules	12
	Total formula weight	1042.2
All*	Total formula weight	86161.5

*Water molecules are not included.