8S90
Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (B, A, C, D, E...) | Calcium homeostasis modulator protein 1 | polymer | 314 | 34842.5 | 8 | UniProt (Q8IU99) Pfam (PF14798) | Homo sapiens (human) | Protein FAM26C |
| 2 | I (E) | ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | non-polymer | 559.5 | 1 | Chemie (R2R) |
Sequence modifications
B, A, C, D, E, F, G, H: 1 - 303 (UniProt: Q8IU99)
| PDB | External Database | Details |
|---|---|---|
| Pro 86 | Leu 86 | conflict |
| Trp 109 | Ile 109 | engineered mutation |
| Asn 264 | His 264 | conflict |
| Gly 304 | - | expression tag |
| Ser 305 | - | expression tag |
| Ala 306 | - | expression tag |
| Trp 307 | - | expression tag |
| Ser 308 | - | expression tag |
| His 309 | - | expression tag |
| Pro 310 | - | expression tag |
| Gln 311 | - | expression tag |
| Phe 312 | - | expression tag |
| Glu 313 | - | expression tag |
| Lys 314 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 278740.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 559.5 | |
| All* | Total formula weight | 279299.8 |
