8S90
Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 368 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
B | MET1-ASN21 | |
E | ASN73-MET99 | |
F | MET1-ASN21 | |
F | ASN73-MET99 | |
G | MET1-ASN21 | |
G | ASN73-MET99 | |
H | MET1-ASN21 | |
H | ASN73-MET99 | |
B | ASN73-MET99 | |
A | MET1-ASN21 | |
A | ASN73-MET99 | |
C | MET1-ASN21 | |
C | ASN73-MET99 | |
D | MET1-ASN21 | |
D | ASN73-MET99 | |
E | MET1-ASN21 |
site_id | SWS_FT_FI2 |
Number of Residues | 120 |
Details | TRANSMEM: Helical; Name=S1 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
Chain | Residue | Details |
B | GLY22-ALA37 | |
A | GLY22-ALA37 | |
C | GLY22-ALA37 | |
D | GLY22-ALA37 | |
E | GLY22-ALA37 | |
F | GLY22-ALA37 | |
G | GLY22-ALA37 | |
H | GLY22-ALA37 |
site_id | SWS_FT_FI3 |
Number of Residues | 520 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
B | PHE38-ASN49 | |
E | LEU126-LEU180 | |
F | PHE38-ASN49 | |
F | LEU126-LEU180 | |
G | PHE38-ASN49 | |
G | LEU126-LEU180 | |
H | PHE38-ASN49 | |
H | LEU126-LEU180 | |
B | LEU126-LEU180 | |
A | PHE38-ASN49 | |
A | LEU126-LEU180 | |
C | PHE38-ASN49 | |
C | LEU126-LEU180 | |
D | PHE38-ASN49 | |
D | LEU126-LEU180 | |
E | PHE38-ASN49 |
site_id | SWS_FT_FI4 |
Number of Residues | 176 |
Details | TRANSMEM: Helical; Name=S2 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
Chain | Residue | Details |
B | ALA50-ASN72 | |
A | ALA50-ASN72 | |
C | ALA50-ASN72 | |
D | ALA50-ASN72 | |
E | ALA50-ASN72 | |
F | ALA50-ASN72 | |
G | ALA50-ASN72 | |
H | ALA50-ASN72 |
site_id | SWS_FT_FI5 |
Number of Residues | 200 |
Details | TRANSMEM: Helical; Name=S3 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
Chain | Residue | Details |
B | PHE100-PHE125 | |
A | PHE100-PHE125 | |
C | PHE100-PHE125 | |
D | PHE100-PHE125 | |
E | PHE100-PHE125 | |
F | PHE100-PHE125 | |
G | PHE100-PHE125 | |
H | PHE100-PHE125 |
site_id | SWS_FT_FI6 |
Number of Residues | 200 |
Details | TRANSMEM: Helical; Name=S4 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
Chain | Residue | Details |
B | ARG181-ARG206 | |
A | ARG181-ARG206 | |
C | ARG181-ARG206 | |
D | ARG181-ARG206 | |
E | ARG181-ARG206 | |
F | ARG181-ARG206 | |
G | ARG181-ARG206 | |
H | ARG181-ARG206 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | SITE: Not glycosylated |
Chain | Residue | Details |
B | ASN74 | |
A | ASN74 | |
C | ASN74 | |
D | ASN74 | |
E | ASN74 | |
F | ASN74 | |
G | ASN74 | |
H | ASN74 |
site_id | SWS_FT_FI8 |
Number of Residues | 16 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:D3Z291 |
Chain | Residue | Details |
B | CYS101 | |
E | CYS208 | |
F | CYS101 | |
F | CYS208 | |
G | CYS101 | |
G | CYS208 | |
H | CYS101 | |
H | CYS208 | |
B | CYS208 | |
A | CYS101 | |
A | CYS208 | |
C | CYS101 | |
C | CYS208 | |
D | CYS101 | |
D | CYS208 | |
E | CYS101 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18585350 |
Chain | Residue | Details |
B | ASN140 | |
A | ASN140 | |
C | ASN140 | |
D | ASN140 | |
E | ASN140 | |
F | ASN140 | |
G | ASN140 | |
H | ASN140 |