8S90
Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 368 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 120 |
| Details | Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"H2MCM1","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"37380652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GMP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 520 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 176 |
| Details | Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"UniProtKB","id":"H2MCM1","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"37380652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GMP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 200 |
| Details | Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"H2MCM1","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"37380652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GMP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 200 |
| Details | Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"H2MCM1","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"37380652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GMP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 216 |
| Details | Region: {"description":"Central pore","evidences":[{"source":"UniProtKB","id":"H2MCM1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 232 |
| Details | Region: {"description":"Phospholipid-binding","evidences":[{"source":"PubMed","id":"37380652","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Site: {"description":"Not glycosylated"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"D3Z291","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18585350","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
