8S7C

Ternary Complex of Cachd1, FZD5 and LRP6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G	VWFA and cache domain-containing protein 1	polymer	1102	123058.0	3	UniProt (Q6PDJ1) In PDB	Mus musculus (house mouse)	Cache domain-containing protein 1
2	B, E, H	Frizzled-5	polymer	140	15924.3	3	UniProt (Q9EQD0) Pfam (PF01392) In PDB	Mus musculus (house mouse)	Fz-5,mFz5
3	C, F, I	Low-density lipoprotein receptor-related protein 6	polymer	628	71170.1	3	UniProt (O75581) Pfam (PF00058) Pfam (PF14670) In PDB	Homo sapiens (human)	LRP-6
4	J, K	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	F, G, A, H, I...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	30	Chemie (NAG)

Sequence modifications

A, D, G: 1 - 1094 (UniProt: Q6PDJ1)

PDB	External Database	Details
Thr 1095	-	expression tag
Gly 1096	-	expression tag
Leu 1097	-	expression tag
Glu 1098	-	expression tag
Val 1099	-	expression tag
Leu 1100	-	expression tag
Phe 1101	-	expression tag
Gln 1102	-	expression tag

B, E, H: 27 - 156 (UniProt: Q9EQD0)

PDB	External Database	Details
Glu 24	-	expression tag
Thr 25	-	expression tag
His 26	-	expression tag
Gly 157	-	expression tag
Leu 158	-	expression tag
Glu 159	-	expression tag
Val 160	-	expression tag
Leu 161	-	expression tag
Phe 162	-	expression tag
Gln 163	-	expression tag

C, F, I: 629 - 1244 (UniProt: O75581)

PDB	External Database	Details
Glu 626	-	expression tag
Thr 627	-	expression tag
Gly 628	-	expression tag
Gly 1245	-	expression tag
Thr 1246	-	expression tag
Lys 1247	-	expression tag
His 1248	-	expression tag
His 1249	-	expression tag
His 1250	-	expression tag
His 1251	-	expression tag
His 1252	-	expression tag
His 1253	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	630457.2
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	30
	Total formula weight	6636.2
All*	Total formula weight	637942.3

*Water molecules are not included.