8RP8

Structure of K2 Fab in complex with human CD47 ECD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, H	K2 Fab heavy chain	polymer	223	23468.2	2		Homo sapiens
2	B, L	K2 Fab light chain	polymer	215	23472.1	2		Homo sapiens
3	C, D	Leukocyte surface antigen CD47	polymer	129	14747.5	2	UniProt (Q08722) In PDB	Homo sapiens (human)	Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6
4	A, H	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	B, L	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
7		water	water		18.0	818	Chemie (HOH)

Sequence modifications

C, D: 1 - 123 (UniProt: Q08722)

PDB	External Database	Details
Gly 15	Cys 33	conflict
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	123375.6
Non-Polymers*	Number of molecules	10
	Total formula weight	1723.7
All*	Total formula weight	125099.3

*Water molecules are not included.