8ROZ
Cryo-EM structure of CDK2-cyclin A in complex with CDC25A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 2 | polymer | 298 | 34136.4 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B (B) | Cyclin-A2 | polymer | 263 | 30119.8 | 1 | UniProt (P30274) Pfam (PF00134) Pfam (PF02984) | Bos taurus (cattle) | Cyclin-A |
| 3 | C (C) | M-phase inducer phosphatase 1 | polymer | 190 | 22533.1 | 1 | UniProt (P30304) Pfam (PF00581) | Homo sapiens (human) | Dual specificity phosphatase Cdc25A |
Sequence modifications
B: 170 - 430 (UniProt: P30274)
C: 338 - 524 (UniProt: P30304)
| PDB | External Database | Details |
|---|---|---|
| Met 168 | - | initiating methionine |
| Gly 169 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 335 | - | expression tag |
| Met 336 | - | expression tag |
| Val 337 | - | expression tag |
| Ser 431 | Cys 431 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 86789.4 | |
| All* | Total formula weight | 86789.4 |
