8RGG
Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1.
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 | polymer | 4513 | 515223.0 | 1 | UniProt (P16455) UniProt (Q8NCM8) Pfam (PF02870) Pfam (PF12777) Pfam (PF12781) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) Pfam (PF01035) Pfam (PF08385) Pfam (PF08393) Pfam (PF12774) Pfam (PF21264) Pfam (PF12775) Pfam (PF22597) Pfam (PF12780) In PDB | Homo sapiens (human) | 6-O-methylguanine-DNA methyltransferase,MGMT,O-6-methylguanine-DNA-alkyltransferase,Cytoplasmic dynein 2 heavy chain,Dynein cytoplasmic heavy chain 2,Dynein heavy chain 11,hDHC11,Dynein heavy chain isotype 1B |
2 | C | Cytoplasmic dynein 2 intermediate chain 1 | polymer | 1066 | 122865.2 | 1 | UniProt (Q8WVS4) In PDB | Homo sapiens (human) | Dynein 2 intermediate chain 1,WD repeat-containing protein 60 |
3 | D | Cytoplasmic dynein 2 intermediate chain 2 | polymer | 564 | 60639.1 | 1 | UniProt (Q96EX3) Pfam (PF00400) In PDB | Homo sapiens (human) | Dynein 2 intermediate chain 2,WD repeat-containing protein 34 |
4 | G, H | Dynein light chain roadblock-type 1 | polymer | 96 | 10934.6 | 2 | UniProt (Q9NP97) Pfam (PF03259) In PDB | Homo sapiens (human) | Bithoraxoid-like protein,BLP,Dynein light chain 2A,cytoplasmic,Dynein-associated protein Km23,Roadblock domain-containing protein 1 |
5 | I, J | Dynein light chain 1, cytoplasmic | polymer | 89 | 10381.9 | 2 | UniProt (P63167) Pfam (PF01221) In PDB | Homo sapiens (human) | 8 kDa dynein light chain,DLC8,Dynein light chain LC8-type 1,Protein inhibitor of neuronal nitric oxide synthase,PIN |
Sequence modifications
B: -204 - -22 (UniProt: P16455)
B: 2 - 4307 (UniProt: Q8NCM8)
C: 1 - 1066 (UniProt: Q8WVS4)
D: 1 - 536 (UniProt: Q96EX3)
PDB | External Database | Details |
---|---|---|
Gly -205 | - | expression tag |
Arg -176 | Glu 30 | engineered mutation |
Ile -174 | Lys 32 | engineered mutation |
Phe -173 | Leu 33 | engineered mutation |
Ala -144 | Cys 62 | engineered mutation |
Ser -91 | Gln 115 | engineered mutation |
His -90 | Gln 116 | engineered mutation |
Ala -81 | Lys 125 | engineered mutation |
Thr -79 | Ala 127 | engineered mutation |
Ala -78 | Arg 128 | engineered mutation |
Lys -75 | Gly 131 | engineered mutation |
Thr -74 | Gly 132 | engineered mutation |
Leu -72 | Met 134 | engineered mutation |
Ser -71 | Arg 135 | engineered mutation |
Gln -56 | Cys 150 | engineered mutation |
Gly -55 | Ser 151 | engineered mutation |
Asp -54 | Ser 152 | engineered mutation |
Leu -53 | Gly 153 | engineered mutation |
Asp -52 | Ala 154 | engineered mutation |
Gly -49 | Asn 157 | engineered mutation |
Glu -47 | Ser 159 | engineered mutation |
Leu -21 | - | linker |
Glu -20 | - | linker |
Val -19 | - | linker |
Leu -18 | - | linker |
Phe -17 | - | linker |
Gln -16 | - | linker |
Gly -15 | - | linker |
Pro -14 | - | linker |
Asp -13 | - | linker |
Tyr -12 | - | linker |
Asp -11 | - | linker |
Ile -10 | - | linker |
Pro -9 | - | linker |
Thr -8 | - | linker |
Thr -7 | - | linker |
Leu -6 | - | linker |
Glu -5 | - | linker |
Val -4 | - | linker |
Leu -3 | - | linker |
Phe -2 | - | linker |
Gln -1 | - | linker |
Gly 0 | - | linker |
Pro 1 | - | linker |
PDB | External Database | Details |
---|---|---|
Arg 1413 | Lys 1413 | variant |
Gln 2871 | Arg 2871 | variant |
Val 3680 | Ala 3680 | variant |
PDB | External Database | Details |
---|---|---|
Lys 225 | Asn 225 | conflict |
Phe 292 | Ser 292 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 60 | Trp 60 | conflict |
Trp 537 | - | expression tag |
Ser 538 | - | expression tag |
His 539 | - | expression tag |
Pro 540 | - | expression tag |
Gln 541 | - | expression tag |
Phe 542 | - | expression tag |
Glu 543 | - | expression tag |
Lys 544 | - | expression tag |
Gly 545 | - | expression tag |
Ser 546 | - | expression tag |
Ala 547 | - | expression tag |
Gly 548 | - | expression tag |
Ser 549 | - | expression tag |
Ala 550 | - | expression tag |
Ala 551 | - | expression tag |
Gly 552 | - | expression tag |
Ser 553 | - | expression tag |
Gly 554 | - | expression tag |
Ala 555 | - | expression tag |
Gly 556 | - | expression tag |
Trp 557 | - | expression tag |
Ser 558 | - | expression tag |
His 559 | - | expression tag |
Pro 560 | - | expression tag |
Gln 561 | - | expression tag |
Phe 562 | - | expression tag |
Glu 563 | - | expression tag |
Lys 564 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 741360.3 | |
All* | Total formula weight | 741360.3 |