8RGG

Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000166	molecular_function	nucleotide binding
B	0001673	cellular_component	male germ cell nucleus
B	0003774	molecular_function	cytoskeletal motor activity
B	0003824	molecular_function	catalytic activity
B	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005868	cellular_component	cytoplasmic dynein complex
B	0005874	cellular_component	microtubule
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0005930	cellular_component	axoneme
B	0006281	biological_process	DNA repair
B	0007018	biological_process	microtubule-based movement
B	0007030	biological_process	Golgi organization
B	0008569	molecular_function	minus-end-directed microtubule motor activity
B	0030030	biological_process	cell projection organization
B	0030286	cellular_component	dynein complex
B	0031514	cellular_component	motile cilium
B	0035721	biological_process	intraciliary retrograde transport
B	0045177	cellular_component	apical part of cell
B	0045505	molecular_function	dynein intermediate chain binding
B	0051959	molecular_function	dynein light intermediate chain binding
B	0060271	biological_process	cilium assembly
B	0060294	biological_process	cilium movement involved in cell motility
B	0070062	cellular_component	extracellular exosome
B	0097542	cellular_component	ciliary tip
B	0097729	cellular_component	9+2 motile cilium
C	0000242	cellular_component	pericentriolar material
C	0000922	cellular_component	spindle pole
C	0001673	cellular_component	male germ cell nucleus
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005813	cellular_component	centrosome
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005929	cellular_component	cilium
C	0030030	biological_process	cell projection organization
C	0031021	cellular_component	interphase microtubule organizing center
C	0035721	biological_process	intraciliary retrograde transport
C	0042073	biological_process	intraciliary transport
C	0045503	molecular_function	dynein light chain binding
C	0045504	molecular_function	dynein heavy chain binding
C	0048704	biological_process	embryonic skeletal system morphogenesis
C	0060271	biological_process	cilium assembly
C	0097542	cellular_component	ciliary tip
C	0097546	cellular_component	ciliary base
D	0001673	cellular_component	male germ cell nucleus
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005814	cellular_component	centriole
D	0005829	cellular_component	cytosol
D	0005868	cellular_component	cytoplasmic dynein complex
D	0005929	cellular_component	cilium
D	0005930	cellular_component	axoneme
D	0030175	cellular_component	filopodium
D	0035721	biological_process	intraciliary retrograde transport
D	0036064	cellular_component	ciliary basal body
D	0042073	biological_process	intraciliary transport
D	0045503	molecular_function	dynein light chain binding
D	0045504	molecular_function	dynein heavy chain binding
D	0060271	biological_process	cilium assembly
D	0097014	cellular_component	ciliary plasm
D	0097542	cellular_component	ciliary tip
G	0003777	molecular_function	microtubule motor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005929	cellular_component	cilium
G	0007018	biological_process	microtubule-based movement
G	0007632	biological_process	visual behavior
G	0016020	cellular_component	membrane
G	0030286	cellular_component	dynein complex
G	0032388	biological_process	positive regulation of intracellular transport
G	0035721	biological_process	intraciliary retrograde transport
G	0042802	molecular_function	identical protein binding
G	0045505	molecular_function	dynein intermediate chain binding
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	0097542	cellular_component	ciliary tip
H	0003777	molecular_function	microtubule motor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0005929	cellular_component	cilium
H	0007018	biological_process	microtubule-based movement
H	0007632	biological_process	visual behavior
H	0016020	cellular_component	membrane
H	0030286	cellular_component	dynein complex
H	0032388	biological_process	positive regulation of intracellular transport
H	0035721	biological_process	intraciliary retrograde transport
H	0042802	molecular_function	identical protein binding
H	0045505	molecular_function	dynein intermediate chain binding
H	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
H	0097542	cellular_component	ciliary tip
I	0000776	cellular_component	kinetochore
I	0001673	cellular_component	male germ cell nucleus
I	0004857	molecular_function	enzyme inhibitor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0005875	cellular_component	microtubule associated complex
I	0005886	cellular_component	plasma membrane
I	0005929	cellular_component	cilium
I	0006351	biological_process	DNA-templated transcription
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0007017	biological_process	microtubule-based process
I	0007286	biological_process	spermatid development
I	0008180	cellular_component	COP9 signalosome
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0019899	molecular_function	enzyme binding
I	0021762	biological_process	substantia nigra development
I	0030141	cellular_component	secretory granule
I	0030235	molecular_function	nitric-oxide synthase regulator activity
I	0030286	cellular_component	dynein complex
I	0032388	biological_process	positive regulation of intracellular transport
I	0035721	biological_process	intraciliary retrograde transport
I	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
I	0035861	cellular_component	site of double-strand break
I	0036487	molecular_function	nitric-oxide synthase inhibitor activity
I	0042326	biological_process	negative regulation of phosphorylation
I	0042802	molecular_function	identical protein binding
I	0044458	biological_process	motile cilium assembly
I	0044877	molecular_function	protein-containing complex binding
I	0045505	molecular_function	dynein intermediate chain binding
I	0070821	cellular_component	tertiary granule membrane
I	0072686	cellular_component	mitotic spindle
I	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
I	0097110	molecular_function	scaffold protein binding
I	0097542	cellular_component	ciliary tip
I	0101003	cellular_component	ficolin-1-rich granule membrane
I	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
I	1904115	cellular_component	axon cytoplasm
J	0000776	cellular_component	kinetochore
J	0001673	cellular_component	male germ cell nucleus
J	0004857	molecular_function	enzyme inhibitor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005868	cellular_component	cytoplasmic dynein complex
J	0005874	cellular_component	microtubule
J	0005875	cellular_component	microtubule associated complex
J	0005886	cellular_component	plasma membrane
J	0005929	cellular_component	cilium
J	0006351	biological_process	DNA-templated transcription
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0007017	biological_process	microtubule-based process
J	0007286	biological_process	spermatid development
J	0008180	cellular_component	COP9 signalosome
J	0015630	cellular_component	microtubule cytoskeleton
J	0016020	cellular_component	membrane
J	0019899	molecular_function	enzyme binding
J	0021762	biological_process	substantia nigra development
J	0030141	cellular_component	secretory granule
J	0030235	molecular_function	nitric-oxide synthase regulator activity
J	0030286	cellular_component	dynein complex
J	0032388	biological_process	positive regulation of intracellular transport
J	0035721	biological_process	intraciliary retrograde transport
J	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
J	0035861	cellular_component	site of double-strand break
J	0036487	molecular_function	nitric-oxide synthase inhibitor activity
J	0042326	biological_process	negative regulation of phosphorylation
J	0042802	molecular_function	identical protein binding
J	0044458	biological_process	motile cilium assembly
J	0044877	molecular_function	protein-containing complex binding
J	0045505	molecular_function	dynein intermediate chain binding
J	0070821	cellular_component	tertiary granule membrane
J	0072686	cellular_component	mitotic spindle
J	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
J	0097110	molecular_function	scaffold protein binding
J	0097542	cellular_component	ciliary tip
J	0101003	cellular_component	ficolin-1-rich granule membrane
J	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
J	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
B	ILE-63-VAL-57

---

site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
I	HIS55-GLU69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	25
Details	Region: {"description":"DYNLRB1 binding","evidences":[{"source":"PubMed","id":"30649997","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	44
Details	Region: {"description":"Interaction with ESR1","evidences":[{"source":"PubMed","id":"15891768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15193260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30464262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37696958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---