8RG0
Structure of human eIF3 core from closed 48S translation initiation complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 3 | Eukaryotic translation initiation factor 3 subunit K | polymer | 218 | 25083.6 | 1 | UniProt (Q9UBQ5) In PDB | Homo sapiens (human) | eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28 |
| 2 | 4 | Eukaryotic translation initiation factor 3 subunit F | polymer | 357 | 37593.6 | 1 | UniProt (O00303) In PDB | Homo sapiens (human) | eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47 |
| 3 | 5 | Eukaryotic translation initiation factor 3 subunit L | polymer | 564 | 66803.7 | 1 | UniProt (Q9Y262) In PDB | Homo sapiens (human) | eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein |
| 4 | 6 | Eukaryotic translation initiation factor 3 subunit M | polymer | 374 | 42555.8 | 1 | UniProt (Q7L2H7) In PDB | Homo sapiens (human) | eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1 |
| 5 | 7 | mRNA | polymer | 255 | 82412.4 | 1 | Homo sapiens (human) | ||
| 6 | 8 | Eukaryotic translation initiation factor 3 subunit H | polymer | 352 | 39979.3 | 1 | UniProt (O15372) In PDB | Homo sapiens (human) | eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit |
| 7 | A | 18S rRNA | polymer | 1869 | 603245.5 | 1 | Homo sapiens (human) | ||
| 8 | H | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (P42677) In PDB | Homo sapiens (human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 9 | I | 40S ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (P62277) In PDB | Homo sapiens (human) | Small ribosomal subunit protein uS15 |
| 10 | M | 40S ribosomal protein S17 | polymer | 135 | 15578.2 | 1 | UniProt (P08708) In PDB | Homo sapiens (human) | Small ribosomal subunit protein eS17 |
| 11 | N | 40S ribosomal protein SA | polymer | 295 | 32883.9 | 1 | UniProt (P08865) In PDB | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 12 | O | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (P61247) In PDB | Homo sapiens (human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 13 | P | 40S ribosomal protein S14 | polymer | 151 | 16302.8 | 1 | UniProt (P62263) In PDB | Homo sapiens (human) | Small ribosomal subunit protein uS11 |
| 14 | Q | 40S ribosomal protein S26 | polymer | 115 | 13047.5 | 1 | UniProt (P62854) In PDB | Homo sapiens (human) | Small ribosomal subunit protein eS26 |
| 15 | n | 40S ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (P62857) In PDB | Homo sapiens (human) | Small ribosomal subunit protein eS28 |
| 16 | u | Eukaryotic translation initiation factor 3 subunit A | polymer | 1382 | 166903.8 | 1 | UniProt (Q14152) In PDB | Homo sapiens (human) | eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185 |
| 17 | v | Eukaryotic translation initiation factor 3 subunit E | polymer | 445 | 52281.6 | 1 | UniProt (P60228) In PDB | Homo sapiens (human) | eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48 |
| 18 | x | Eukaryotic translation initiation factor 3 subunit D | polymer | 548 | 64060.8 | 1 | UniProt (O15371) In PDB | Homo sapiens (human) | eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta,eIF3 p66 |
| 19 | y | Eukaryotic translation initiation factor 3 subunit C | polymer | 913 | 105503.9 | 1 | UniProt (Q99613) In PDB | Homo sapiens (human) | eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110 |
| 20 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 21 | Q | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 19 |
| Total formula weight | 1428833.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 89.7 | |
| All* | Total formula weight | 1428923.0 |
