8RG0
Structure of human eIF3 core from closed 48S translation initiation complex
Functional Information from PROSITE/UniProt
| site_id | PS00054 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPiPSD |
| Chain | Residue | Details |
| P | LEU116-ASP138 |
| site_id | PS00362 |
| Number of Residues | 31 |
| Details | RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY |
| Chain | Residue | Details |
| I | VAL98-TYR128 |
| site_id | PS00712 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_S17E Ribosomal protein S17e signature. IpSKkLRNkIAGYvTH |
| Chain | Residue | Details |
| M | ILE41-HIS56 |
| site_id | PS00733 |
| Number of Residues | 8 |
| Details | RIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH |
| Chain | Residue | Details |
| Q | TYR73-HIS80 |
| site_id | PS00961 |
| Number of Residues | 9 |
| Details | RIBOSOMAL_S28E Ribosomal protein S28e signature. ESEREARrL |
| Chain | Residue | Details |
| n | GLU60-LEU68 |
| site_id | PS00962 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. VlKFLAAGTHLG |
| Chain | Residue | Details |
| N | VAL15-GLY26 |
| site_id | PS00963 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlLVVtDpraDhqpLtEasyvNLP |
| Chain | Residue | Details |
| N | PRO119-PRO143 |
| site_id | PS01168 |
| Number of Residues | 33 |
| Details | RIBOSOMAL_S27E Ribosomal protein S27e signature. KCpgCykittvFShAqtvvlCvgCStvLcqPtG |
| Chain | Residue | Details |
| H | LYS36-GLY68 |
| site_id | PS01191 |
| Number of Residues | 13 |
| Details | RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVfEvSLaDL |
| Chain | Residue | Details |
| O | LEU62-LEU74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17322308 |
| Chain | Residue | Details |
| y | SER9 | |
| y | SER11 | |
| y | SER13 | |
| y | SER15 | |
| y | SER16 | |
| y | SER18 | |
| y | SER39 | |
| y | SER166 | |
| y | SER909 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8R1B4 |
| Chain | Residue | Details |
| y | LYS99 | |
| y | LYS643 | |
| H | CYS56 | |
| H | CYS59 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8R1B4 |
| Chain | Residue | Details |
| y | SER178 | |
| y | SER181 | |
| y | SER182 | |
| u | SER1028 | |
| u | SER1188 | |
| u | SER1262 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17322308 |
| Chain | Residue | Details |
| y | THR524 | |
| u | SER1198 | |
| u | SER1336 | |
| P | LYS106 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P60229 |
| Chain | Residue | Details |
| v | TYR445 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:17322308 |
| Chain | Residue | Details |
| u | SER1364 | |
| I | LYS43 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| O | SER263 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| O | LYS34 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| O | LYS249 |
