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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8RC4

Structure of Integrator-PP2A complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1pSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformpolymer59165579.51UniProt (P30153)
Pfam (PF02985)
In PDB		Homo sapiens (human)
2qSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoformpolymer31135836.31UniProt (P67775)
Pfam (PF00149)
In PDB		Homo sapiens (human)
3rDSS1polymer313754.01Trichoplusia ni
4aIntegrator complex subunit 1polymer2192244776.11UniProt (Q8N201)
Pfam (PF12432)
Pfam (PF22929)
Pfam (PF22927)
Pfam (PF22928)
In PDB		Homo sapiens (human)
5bIntegrator complex subunit 2polymer1204134451.61UniProt (Q9H0H0)
Pfam (PF14750)
In PDB		Homo sapiens (human)Int2
6dIntegrator complex subunit 4polymer963108306.81UniProt (Q96HW7)
Pfam (PF20168)
Pfam (PF13646)
In PDB		Homo sapiens (human)Int4
7eIntegrator complex subunit 5polymer1021108316.41UniProt (Q6P9B9)
Pfam (PF14837)
Pfam (PF14838)
In PDB		Homo sapiens (human)
8fIntegrator complex subunit 6polymer892101166.71UniProt (Q9UL03)
Pfam (PF13519)
Pfam (PF15300)
In PDB		Homo sapiens (human)
9gIntegrator complex subunit 7polymer964107153.81UniProt (Q9NVH2)
Pfam (PF22965)
In PDB		Homo sapiens (human)
10hIntegrator complex subunit 8polymer995113219.91UniProt (Q75QN2)
In PDB		Homo sapiens (human)Int8,Protein kaonashi-1
11iIntegrator complex subunit 9polymer65873891.21UniProt (Q9NV88)
Pfam (PF16661)
Pfam (PF10996)
Pfam (PF21382)
In PDB		Homo sapiens (human)Int9,Protein related to CPSF subunits of 74 kDa,RC-74
12kIntegrator complex subunit 11polymer60267956.81UniProt (Q5TA45)
Pfam (PF16661)
Pfam (PF10996)
Pfam (PF07521)
Pfam (PF21386)
In PDB		Homo sapiens (human)
13mIntegrator complex subunit 13polymer70680345.21UniProt (Q9NVM9)
Pfam (PF10221)
In PDB		Homo sapiens (human)Cell cycle regulator Mat89Bb homolog,Germ cell tumor 1,Protein asunder homolog,Sarcoma antigen NY-SAR-95
14jIntegrator complex subunit 10polymer71082339.91UniProt (Q9NVR2)
Pfam (PF21045)
In PDB		Homo sapiens (human)Int10
15nIntegrator complex subunit 14polymer51857526.51UniProt (Q96SY0)
Pfam (PF13519)
Pfam (PF19435)
Pfam (PF20504)
In PDB		Homo sapiens (human)von Willebrand factor A domain-containing protein 9
16oIntegrator complex subunit 15polymer45150303.61UniProt (Q96N11)
Pfam (PF14964)
In PDB		Homo sapiens (human)
17qMANGANESE (II) IONnon-polymer54.92Chemie (MN)
18kZINC IONnon-polymer65.42Chemie (ZN)
Sequence modifications
p: 1 - 589 (UniProt: P30153)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
q: 1 - 309 (UniProt: P67775)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Asn 88Asp 88engineered mutation
a: 1 - 2190 (UniProt: Q8N201)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
e: 1 - 1019 (UniProt: Q6P9B9)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
f: 1 - 887 (UniProt: Q9UL03)
PDBExternal DatabaseDetails
Tyr -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Ser -1-expression tag
Asn 0-expression tag
g: 1 - 962 (UniProt: Q9NVH2)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
k: 1 - 600 (UniProt: Q5TA45)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Gln 203Glu 203engineered mutation
o: 1 - 449 (UniProt: Q96N11)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains16
Total formula weight1434924.3
Non-Polymers*Number of molecules4
Total formula weight240.7
All*Total formula weight1435165.0
*Water molecules are not included.

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PDB entries from 2024-10-09

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