Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RC4

Structure of Integrator-PP2A complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0016020	cellular_component	membrane
a	0016180	biological_process	snRNA processing
a	0031965	cellular_component	nuclear membrane
a	0032039	cellular_component	integrator complex
a	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
a	0034474	biological_process	U2 snRNA 3'-end processing
a	0160232	cellular_component	INTAC complex
a	0160240	biological_process	RNA polymerase II transcription initiation surveillance
b	0016180	biological_process	snRNA processing
b	0032039	cellular_component	integrator complex
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005730	cellular_component	nucleolus
d	0005737	cellular_component	cytoplasm
d	0016180	biological_process	snRNA processing
d	0030674	molecular_function	protein-macromolecule adaptor activity
d	0032039	cellular_component	integrator complex
d	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
d	0160232	cellular_component	INTAC complex
d	0160240	biological_process	RNA polymerase II transcription initiation surveillance
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0016020	cellular_component	membrane
e	0016180	biological_process	snRNA processing
e	0031965	cellular_component	nuclear membrane
e	0032039	cellular_component	integrator complex
e	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
e	0034472	biological_process	snRNA 3'-end processing
e	0160232	cellular_component	INTAC complex
e	0160240	biological_process	RNA polymerase II transcription initiation surveillance
f	0000785	cellular_component	chromatin
f	0004888	molecular_function	transmembrane signaling receptor activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005694	cellular_component	chromosome
f	0016180	biological_process	snRNA processing
f	0030674	molecular_function	protein-macromolecule adaptor activity
f	0032039	cellular_component	integrator complex
f	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
f	0034472	biological_process	snRNA 3'-end processing
f	0071168	biological_process	protein localization to chromatin
f	0160232	cellular_component	INTAC complex
f	0160240	biological_process	RNA polymerase II transcription initiation surveillance
g	0000077	biological_process	DNA damage checkpoint signaling
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005694	cellular_component	chromosome
g	0005737	cellular_component	cytoplasm
g	0006974	biological_process	DNA damage response
g	0016180	biological_process	snRNA processing
g	0016604	cellular_component	nuclear body
g	0032039	cellular_component	integrator complex
g	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
g	0034472	biological_process	snRNA 3'-end processing
g	0071479	biological_process	cellular response to ionizing radiation
g	0160232	cellular_component	INTAC complex
g	0160240	biological_process	RNA polymerase II transcription initiation surveillance
h	0000785	cellular_component	chromatin
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0016180	biological_process	snRNA processing
h	0032039	cellular_component	integrator complex
h	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
h	0034472	biological_process	snRNA 3'-end processing
h	0071168	biological_process	protein localization to chromatin
h	0160232	cellular_component	INTAC complex
h	0160240	biological_process	RNA polymerase II transcription initiation surveillance
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0016180	biological_process	snRNA processing
i	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
i	0032039	cellular_component	integrator complex
i	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
i	0034472	biological_process	snRNA 3'-end processing
i	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
i	0090287	biological_process	regulation of cellular response to growth factor stimulus
i	0160232	cellular_component	INTAC complex
i	0160240	biological_process	RNA polymerase II transcription initiation surveillance
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0016180	biological_process	snRNA processing
j	0032039	cellular_component	integrator complex
j	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
j	0160232	cellular_component	INTAC complex
j	0160240	biological_process	RNA polymerase II transcription initiation surveillance
k	0004521	molecular_function	RNA endonuclease activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0016180	biological_process	snRNA processing
k	0016787	molecular_function	hydrolase activity
k	0032039	cellular_component	integrator complex
k	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
k	0034472	biological_process	snRNA 3'-end processing
k	0046872	molecular_function	metal ion binding
k	0072562	cellular_component	blood microparticle
k	0160232	cellular_component	INTAC complex
k	0160240	biological_process	RNA polymerase II transcription initiation surveillance
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0007052	biological_process	mitotic spindle organization
m	0007346	biological_process	regulation of mitotic cell cycle
m	0016180	biological_process	snRNA processing
m	0016604	cellular_component	nuclear body
m	0030317	biological_process	flagellated sperm motility
m	0032039	cellular_component	integrator complex
m	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
m	0051301	biological_process	cell division
m	0051642	biological_process	centrosome localization
m	0080154	biological_process	regulation of fertilization
m	0090435	biological_process	protein localization to nuclear envelope
m	0140297	molecular_function	DNA-binding transcription factor binding
m	0160232	cellular_component	INTAC complex
m	0160240	biological_process	RNA polymerase II transcription initiation surveillance
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0016180	biological_process	snRNA processing
n	0032039	cellular_component	integrator complex
n	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
n	0034472	biological_process	snRNA 3'-end processing
n	0046872	molecular_function	metal ion binding
n	0160232	cellular_component	INTAC complex
n	0160240	biological_process	RNA polymerase II transcription initiation surveillance
o	0005634	cellular_component	nucleus
o	0005694	cellular_component	chromosome
o	0016180	biological_process	snRNA processing
o	0032039	cellular_component	integrator complex
o	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
o	0160232	cellular_component	INTAC complex
o	0160240	biological_process	RNA polymerase II transcription initiation surveillance
p	0000159	cellular_component	protein phosphatase type 2A complex
p	0000775	cellular_component	chromosome, centromeric region
p	0000785	cellular_component	chromatin
p	0004722	molecular_function	protein serine/threonine phosphatase activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005694	cellular_component	chromosome
p	0005737	cellular_component	cytoplasm
p	0005739	cellular_component	mitochondrion
p	0005829	cellular_component	cytosol
p	0007059	biological_process	chromosome segregation
p	0015630	cellular_component	microtubule cytoskeleton
p	0016020	cellular_component	membrane
p	0016180	biological_process	snRNA processing
p	0016328	cellular_component	lateral plasma membrane
p	0019888	molecular_function	protein phosphatase regulator activity
p	0030425	cellular_component	dendrite
p	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
p	0035330	biological_process	regulation of hippo signaling
p	0035331	biological_process	negative regulation of hippo signaling
p	0035556	biological_process	intracellular signal transduction
p	0040008	biological_process	regulation of growth
p	0043005	cellular_component	neuron projection
p	0043025	cellular_component	neuronal cell body
p	0043029	biological_process	T cell homeostasis
p	0045202	cellular_component	synapse
p	0045595	biological_process	regulation of cell differentiation
p	0046982	molecular_function	protein heterodimerization activity
p	0051225	biological_process	spindle assembly
p	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
p	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
p	0065003	biological_process	protein-containing complex assembly
p	0070062	cellular_component	extracellular exosome
p	0090443	cellular_component	FAR/SIN/STRIPAK complex
p	0098978	cellular_component	glutamatergic synapse
p	0160232	cellular_component	INTAC complex
p	0160240	biological_process	RNA polymerase II transcription initiation surveillance
p	1990405	molecular_function	protein antigen binding
q	0000159	cellular_component	protein phosphatase type 2A complex
q	0000278	biological_process	mitotic cell cycle
q	0000775	cellular_component	chromosome, centromeric region
q	0000785	cellular_component	chromatin
q	0000922	cellular_component	spindle pole
q	0004721	molecular_function	phosphoprotein phosphatase activity
q	0004722	molecular_function	protein serine/threonine phosphatase activity
q	0004725	molecular_function	protein tyrosine phosphatase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005694	cellular_component	chromosome
q	0005737	cellular_component	cytoplasm
q	0005739	cellular_component	mitochondrion
q	0005829	cellular_component	cytosol
q	0005886	cellular_component	plasma membrane
q	0006357	biological_process	regulation of transcription by RNA polymerase II
q	0006470	biological_process	protein dephosphorylation
q	0010288	biological_process	response to lead ion
q	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
q	0015630	cellular_component	microtubule cytoskeleton
q	0016020	cellular_component	membrane
q	0016180	biological_process	snRNA processing
q	0016787	molecular_function	hydrolase activity
q	0031113	biological_process	regulation of microtubule polymerization
q	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
q	0035330	biological_process	regulation of hippo signaling
q	0035331	biological_process	negative regulation of hippo signaling
q	0035556	biological_process	intracellular signal transduction
q	0040008	biological_process	regulation of growth
q	0043029	biological_process	T cell homeostasis
q	0045121	cellular_component	membrane raft
q	0045202	cellular_component	synapse
q	0045595	biological_process	regulation of cell differentiation
q	0046872	molecular_function	metal ion binding
q	0046982	molecular_function	protein heterodimerization activity
q	0048156	molecular_function	tau protein binding
q	0050811	molecular_function	GABA receptor binding
q	0051321	biological_process	meiotic cell cycle
q	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
q	0070062	cellular_component	extracellular exosome
q	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
q	0090443	cellular_component	FAR/SIN/STRIPAK complex
q	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
q	0160232	cellular_component	INTAC complex
q	0160240	biological_process	RNA polymerase II transcription initiation surveillance
q	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
q	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
q	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
q	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
q	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
r	0006406	biological_process	mRNA export from nucleus
r	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
r	0043248	biological_process	proteasome assembly

Functional Information from PROSITE/UniProt

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QPeTYYKWDN

Chain	Residue	Details
a	GLN620-ASN629

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADEfV

Chain	Residue	Details
f	MET627-VAL635

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
q	LEU114-GLU119

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Repeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	37
Details	Repeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	38
Details	Repeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	37
Details	Repeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	38
Details	Repeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	38
Details	Repeat: {"description":"HEAT 6","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	38
Details	Repeat: {"description":"HEAT 7","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	42
Details	Repeat: {"description":"HEAT 8","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	38
Details	Repeat: {"description":"HEAT 9","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	38
Details	Repeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	38
Details	Repeat: {"description":"HEAT 11","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	38
Details	Repeat: {"description":"HEAT 12","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	38
Details	Repeat: {"description":"HEAT 13","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	38
Details	Repeat: {"description":"HEAT 14","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	391
Details	Region: {"description":"PP2A subunit B binding"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	274
Details	Region: {"description":"Polyoma small and medium T antigens Binding"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	154
Details	Region: {"description":"SV40 small T antigen binding"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	96
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	36
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	38
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	38
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	224
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	38
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	36
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	33
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	33
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	5
Details	Motif: {"description":"WFEF motif","evidences":[{"source":"PubMed","id":"32966759","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q95TS5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	5
Details	Motif: {"description":"HXHXDH motif"}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"28396433","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32697989","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33548203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9VAH9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"36454007","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38906142","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8K2A7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	202
Details	Domain: {"description":"VWFA"}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38906142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)