8RBZ
Structure of Integrator-PP2A-SOSS-CTD post-termination complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK | polymer | 9 | 784.0 | 1 | Sus scrofa (pig) | ||
| 2 | B (B) | SOSS complex subunit B1 | polymer | 213 | 22566.1 | 1 | UniProt (Q9BQ15) Pfam (PF21473) | Homo sapiens (human) | |
| 3 | C (C) | SOSS complex subunit C | polymer | 106 | 11643.0 | 1 | UniProt (Q9NRY2) Pfam (PF15925) | Homo sapiens (human) | |
| 4 | D (Y) | DNA-directed RNA polymerase subunit | polymer | 13 | 1356.4 | 1 | UniProt (I3LJR4) Pfam (PF05001) | Sus scrofa (pig) | |
| 5 | E (a) | Integrator complex subunit 1 | polymer | 2192 | 244776.1 | 1 | UniProt (Q8N201) Pfam (PF12432) Pfam (PF22929) Pfam (PF22927) Pfam (PF22928) | Homo sapiens (human) | |
| 6 | F (b) | Integrator complex subunit 2 | polymer | 1204 | 134451.6 | 1 | UniProt (Q9H0H0) Pfam (PF14750) | Homo sapiens (human) | Int2 |
| 7 | G (c) | Integrator complex subunit 3 | polymer | 1042 | 118155.6 | 1 | UniProt (Q68E01) Pfam (PF10189) | Homo sapiens (human) | |
| 8 | H (d) | Integrator complex subunit 4 | polymer | 963 | 108306.8 | 1 | UniProt (Q96HW7) Pfam (PF20168) Pfam (PF13646) | Homo sapiens (human) | Int4 |
| 9 | I (e) | Integrator complex subunit 5 | polymer | 1021 | 108316.4 | 1 | UniProt (Q6P9B9) Pfam (PF14837) Pfam (PF14838) | Homo sapiens (human) | |
| 10 | J (f) | Integrator complex subunit 6 | polymer | 889 | 100728.3 | 1 | UniProt (Q9UL03) Pfam (PF13519) Pfam (PF15300) | Homo sapiens (human) | |
| 11 | K (g) | Integrator complex subunit 7 | polymer | 964 | 107153.8 | 1 | UniProt (Q9NVH2) Pfam (PF22965) | Homo sapiens (human) | |
| 12 | L (h) | Integrator complex subunit 8 | polymer | 995 | 113219.9 | 1 | UniProt (Q75QN2) | Homo sapiens (human) | Int8,Protein kaonashi-1 |
| 13 | M (i) | Integrator complex subunit 9 | polymer | 658 | 73891.2 | 1 | UniProt (Q9NV88) Pfam (PF16661) Pfam (PF10996) Pfam (PF21382) | Homo sapiens (human) | Int9,Protein related to CPSF subunits of 74 kDa,RC-74 |
| 14 | N (j) | Integrator complex subunit 10 | polymer | 710 | 82339.9 | 1 | UniProt (Q9NVR2) Pfam (PF21045) | Homo sapiens (human) | Int10 |
| 15 | O (k) | Integrator complex subunit 11 | polymer | 602 | 67970.8 | 1 | UniProt (Q5TA45) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF21386) | Homo sapiens (human) | |
| 16 | P (n) | Integrator complex subunit 14 | polymer | 518 | 57526.5 | 1 | UniProt (Q96SY0) Pfam (PF13519) Pfam (PF19435) Pfam (PF20504) | Homo sapiens (human) | von Willebrand factor A domain-containing protein 9 |
| 17 | Q (o) | Integrator complex subunit 15 | polymer | 451 | 50303.6 | 1 | UniProt (Q96N11) Pfam (PF14964) | Homo sapiens (human) | |
| 18 | R (p) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 591 | 65579.5 | 1 | UniProt (P30153) Pfam (PF02985) | Homo sapiens (human) | |
| 19 | S (q) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 311 | 35836.3 | 1 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | |
| 20 | T (r) | DSS1 | polymer | 27 | 3383.5 | 1 | Trichoplusia ni | ||
| 21 | U (m) | Integrator complex subunit 13 | polymer | 706 | 80345.2 | 1 | UniProt (Q9NVM9) Pfam (PF10221) | Homo sapiens (human) | Cell cycle regulator Mat89Bb homolog,Germ cell tumor 1,Protein asunder homolog,Sarcoma antigen NY-SAR-95 |
| 22 | V, W (k) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 23 | X, Y (q) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) |
Sequence modifications
B: 1 - 211 (UniProt: Q9BQ15)
C: 1 - 104 (UniProt: Q9NRY2)
a: 1 - 2190 (UniProt: Q8N201)
e: 1 - 1019 (UniProt: Q6P9B9)
f: 1 - 887 (UniProt: Q9UL03)
g: 1 - 962 (UniProt: Q9NVH2)
k: 1 - 600 (UniProt: Q5TA45)
o: 1 - 449 (UniProt: Q96N11)
p: 1 - 589 (UniProt: P30153)
q: 1 - 309 (UniProt: P67775)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Gln 203 | Glu 203 | engineered mutation |
| Glu 487 | Asp 487 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Asn 88 | Asp 88 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 1588634.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 240.7 | |
| All* | Total formula weight | 1588875.0 |
