8RBZ

Structure of Integrator-PP2A-SOSS-CTD post-termination complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0001832	biological_process	blastocyst growth
a	0001833	biological_process	inner cell mass cell proliferation
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0007566	biological_process	embryo implantation
a	0016020	cellular_component	membrane
a	0016180	biological_process	snRNA processing
a	0031965	cellular_component	nuclear membrane
a	0032039	cellular_component	integrator complex
a	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
a	0034474	biological_process	U2 snRNA 3'-end processing
a	0043066	biological_process	negative regulation of apoptotic process
a	0160232	cellular_component	INTAC complex
a	0160240	biological_process	RNA polymerase II transcription initiation surveillance
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0016020	cellular_component	membrane
b	0016180	biological_process	snRNA processing
b	0031965	cellular_component	nuclear membrane
b	0032039	cellular_component	integrator complex
b	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
b	0034472	biological_process	snRNA 3'-end processing
b	0160232	cellular_component	INTAC complex
b	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0010212	biological_process	response to ionizing radiation
B	0035861	cellular_component	site of double-strand break
B	0044818	biological_process	mitotic G2/M transition checkpoint
B	0061730	molecular_function	C-rich strand telomeric DNA binding
B	0070182	molecular_function	DNA polymerase binding
B	0070200	biological_process	establishment of protein localization to telomere
B	0070876	cellular_component	SOSS complex
B	0098505	molecular_function	G-rich strand telomeric DNA binding
B	1904355	biological_process	positive regulation of telomere capping
c	0000724	biological_process	double-strand break repair via homologous recombination
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0006281	biological_process	DNA repair
c	0006974	biological_process	DNA damage response
c	0010212	biological_process	response to ionizing radiation
c	0016180	biological_process	snRNA processing
c	0032039	cellular_component	integrator complex
c	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
c	0035861	cellular_component	site of double-strand break
c	0044818	biological_process	mitotic G2/M transition checkpoint
c	0070876	cellular_component	SOSS complex
c	0160232	cellular_component	INTAC complex
c	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0010212	biological_process	response to ionizing radiation
C	0035861	cellular_component	site of double-strand break
C	0044818	biological_process	mitotic G2/M transition checkpoint
C	0070876	cellular_component	SOSS complex
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005730	cellular_component	nucleolus
d	0005737	cellular_component	cytoplasm
d	0016180	biological_process	snRNA processing
d	0030674	molecular_function	protein-macromolecule adaptor activity
d	0032039	cellular_component	integrator complex
d	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
d	0160232	cellular_component	INTAC complex
d	0160240	biological_process	RNA polymerase II transcription initiation surveillance
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0016020	cellular_component	membrane
e	0016180	biological_process	snRNA processing
e	0031965	cellular_component	nuclear membrane
e	0032039	cellular_component	integrator complex
e	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
e	0034472	biological_process	snRNA 3'-end processing
e	0160232	cellular_component	INTAC complex
e	0160240	biological_process	RNA polymerase II transcription initiation surveillance
f	0000785	cellular_component	chromatin
f	0004888	molecular_function	transmembrane signaling receptor activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005694	cellular_component	chromosome
f	0006366	biological_process	transcription by RNA polymerase II
f	0006368	biological_process	transcription elongation by RNA polymerase II
f	0015629	cellular_component	actin cytoskeleton
f	0016180	biological_process	snRNA processing
f	0030674	molecular_function	protein-macromolecule adaptor activity
f	0032039	cellular_component	integrator complex
f	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
f	0034472	biological_process	snRNA 3'-end processing
f	0071168	biological_process	protein localization to chromatin
f	0160232	cellular_component	INTAC complex
f	0160240	biological_process	RNA polymerase II transcription initiation surveillance
g	0000077	biological_process	DNA damage checkpoint signaling
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005694	cellular_component	chromosome
g	0005737	cellular_component	cytoplasm
g	0006974	biological_process	DNA damage response
g	0016180	biological_process	snRNA processing
g	0016604	cellular_component	nuclear body
g	0032039	cellular_component	integrator complex
g	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
g	0034472	biological_process	snRNA 3'-end processing
g	0071479	biological_process	cellular response to ionizing radiation
g	0160232	cellular_component	INTAC complex
g	0160240	biological_process	RNA polymerase II transcription initiation surveillance
h	0000785	cellular_component	chromatin
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0016180	biological_process	snRNA processing
h	0032039	cellular_component	integrator complex
h	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
h	0034472	biological_process	snRNA 3'-end processing
h	0071168	biological_process	protein localization to chromatin
h	0160232	cellular_component	INTAC complex
h	0160240	biological_process	RNA polymerase II transcription initiation surveillance
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0016180	biological_process	snRNA processing
i	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
i	0032039	cellular_component	integrator complex
i	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
i	0034472	biological_process	snRNA 3'-end processing
i	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
i	0090287	biological_process	regulation of cellular response to growth factor stimulus
i	0160232	cellular_component	INTAC complex
i	0160240	biological_process	RNA polymerase II transcription initiation surveillance
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0016180	biological_process	snRNA processing
j	0032039	cellular_component	integrator complex
j	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
j	0160232	cellular_component	INTAC complex
j	0160240	biological_process	RNA polymerase II transcription initiation surveillance
k	0004521	molecular_function	RNA endonuclease activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006366	biological_process	transcription by RNA polymerase II
k	0006368	biological_process	transcription elongation by RNA polymerase II
k	0016180	biological_process	snRNA processing
k	0016787	molecular_function	hydrolase activity
k	0032039	cellular_component	integrator complex
k	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
k	0034472	biological_process	snRNA 3'-end processing
k	0046872	molecular_function	metal ion binding
k	0072562	cellular_component	blood microparticle
k	0160232	cellular_component	INTAC complex
k	0160240	biological_process	RNA polymerase II transcription initiation surveillance
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0007052	biological_process	mitotic spindle organization
m	0007346	biological_process	regulation of mitotic cell cycle
m	0016180	biological_process	snRNA processing
m	0016604	cellular_component	nuclear body
m	0030317	biological_process	flagellated sperm motility
m	0032039	cellular_component	integrator complex
m	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
m	0051301	biological_process	cell division
m	0051642	biological_process	centrosome localization
m	0080154	biological_process	regulation of fertilization
m	0090435	biological_process	protein localization to nuclear envelope
m	0140297	molecular_function	DNA-binding transcription factor binding
m	0160232	cellular_component	INTAC complex
m	0160240	biological_process	RNA polymerase II transcription initiation surveillance
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0016180	biological_process	snRNA processing
n	0032039	cellular_component	integrator complex
n	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
n	0034472	biological_process	snRNA 3'-end processing
n	0046872	molecular_function	metal ion binding
n	0160232	cellular_component	INTAC complex
n	0160240	biological_process	RNA polymerase II transcription initiation surveillance
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0001654	biological_process	eye development
o	0005634	cellular_component	nucleus
o	0005694	cellular_component	chromosome
o	0007420	biological_process	brain development
o	0032039	cellular_component	integrator complex
o	0160232	cellular_component	INTAC complex
o	0160240	biological_process	RNA polymerase II transcription initiation surveillance
p	0000159	cellular_component	protein phosphatase type 2A complex
p	0000775	cellular_component	chromosome, centromeric region
p	0000785	cellular_component	chromatin
p	0004722	molecular_function	protein serine/threonine phosphatase activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005694	cellular_component	chromosome
p	0005737	cellular_component	cytoplasm
p	0005739	cellular_component	mitochondrion
p	0005829	cellular_component	cytosol
p	0005886	cellular_component	plasma membrane
p	0006366	biological_process	transcription by RNA polymerase II
p	0006368	biological_process	transcription elongation by RNA polymerase II
p	0007059	biological_process	chromosome segregation
p	0007143	biological_process	female meiotic nuclear division
p	0015630	cellular_component	microtubule cytoskeleton
p	0016020	cellular_component	membrane
p	0016328	cellular_component	lateral plasma membrane
p	0019888	molecular_function	protein phosphatase regulator activity
p	0030425	cellular_component	dendrite
p	0035331	biological_process	negative regulation of hippo signaling
p	0035556	biological_process	intracellular signal transduction
p	0040008	biological_process	regulation of growth
p	0042995	cellular_component	cell projection
p	0043005	cellular_component	neuron projection
p	0043025	cellular_component	neuronal cell body
p	0043029	biological_process	T cell homeostasis
p	0045202	cellular_component	synapse
p	0045595	biological_process	regulation of cell differentiation
p	0046982	molecular_function	protein heterodimerization activity
p	0051225	biological_process	spindle assembly
p	0051232	biological_process	meiotic spindle elongation
p	0051306	biological_process	mitotic sister chromatid separation
p	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
p	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
p	0065003	biological_process	protein-containing complex assembly
p	0070062	cellular_component	extracellular exosome
p	0090443	cellular_component	FAR/SIN/STRIPAK complex
p	0098978	cellular_component	glutamatergic synapse
p	0160232	cellular_component	INTAC complex
p	0160240	biological_process	RNA polymerase II transcription initiation surveillance
p	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
p	1990405	molecular_function	protein antigen binding
p	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
q	0000159	cellular_component	protein phosphatase type 2A complex
q	0000278	biological_process	mitotic cell cycle
q	0000775	cellular_component	chromosome, centromeric region
q	0000785	cellular_component	chromatin
q	0000922	cellular_component	spindle pole
q	0004721	molecular_function	phosphoprotein phosphatase activity
q	0004722	molecular_function	protein serine/threonine phosphatase activity
q	0004725	molecular_function	protein tyrosine phosphatase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005694	cellular_component	chromosome
q	0005737	cellular_component	cytoplasm
q	0005739	cellular_component	mitochondrion
q	0005829	cellular_component	cytosol
q	0005856	cellular_component	cytoskeleton
q	0005886	cellular_component	plasma membrane
q	0006357	biological_process	regulation of transcription by RNA polymerase II
q	0006366	biological_process	transcription by RNA polymerase II
q	0006368	biological_process	transcription elongation by RNA polymerase II
q	0006470	biological_process	protein dephosphorylation
q	0007498	biological_process	mesoderm development
q	0008287	cellular_component	protein serine/threonine phosphatase complex
q	0010288	biological_process	response to lead ion
q	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
q	0015630	cellular_component	microtubule cytoskeleton
q	0016020	cellular_component	membrane
q	0016787	molecular_function	hydrolase activity
q	0031113	biological_process	regulation of microtubule polymerization
q	0035331	biological_process	negative regulation of hippo signaling
q	0035556	biological_process	intracellular signal transduction
q	0035970	biological_process	peptidyl-threonine dephosphorylation
q	0040008	biological_process	regulation of growth
q	0043029	biological_process	T cell homeostasis
q	0045121	cellular_component	membrane raft
q	0045202	cellular_component	synapse
q	0045595	biological_process	regulation of cell differentiation
q	0046872	molecular_function	metal ion binding
q	0046982	molecular_function	protein heterodimerization activity
q	0048156	molecular_function	tau protein binding
q	0050811	molecular_function	GABA receptor binding
q	0051321	biological_process	meiotic cell cycle
q	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
q	0070062	cellular_component	extracellular exosome
q	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
q	0090443	cellular_component	FAR/SIN/STRIPAK complex
q	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
q	0160232	cellular_component	INTAC complex
q	0160240	biological_process	RNA polymerase II transcription initiation surveillance
q	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
q	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
q	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
q	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
q	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
r	0006406	biological_process	mRNA export from nucleus
r	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
r	0043248	biological_process	proteasome assembly
Y	0003677	molecular_function	DNA binding
Y	0006366	biological_process	transcription by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QPeTYYKWDN

Chain	Residue	Details
a	GLN620-ASN629

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site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADEfV

Chain	Residue	Details
f	MET627-VAL635

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site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
Y	TYR1622-SER1628

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site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
q	LEU114-GLU119

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
e	LEU534-PHE554
e	LEU856-VAL876
e	VAL930-LEU950
i	ARG511

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
e	SER2
a	SER1395
q	ASP85

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
e	SER279
q	HIS167
q	HIS241

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
e	SER1010
k	HIS73

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
a	SER87
a	SER924

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
a	SER307

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
a	SER1318

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site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6P4S8

Chain	Residue	Details
a	SER1335
a	SER1336
k	LYS462
k	LYS475

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