8R9A
A soakable crystal form of human CDK7 in complex with AMP-PNP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cyclin-dependent kinase 7 | polymer | 371 | 42235.6 | 1 | UniProt (P50613) Pfam (PF00069) In PDB | Homo sapiens (human) | |
2 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
3 | A | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol | non-polymer | 394.5 | 1 | Chemie (I74) | |||
4 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 1 - 346 (UniProt: P50613)
PDB | External Database | Details |
---|---|---|
Met -24 | - | initiating methionine |
Ser -23 | - | expression tag |
Tyr -22 | - | expression tag |
Tyr -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Asp -14 | - | expression tag |
Tyr -13 | - | expression tag |
Asp -12 | - | expression tag |
Ile -11 | - | expression tag |
Pro -10 | - | expression tag |
Thr -9 | - | expression tag |
Thr -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Arg 132 | Trp 132 | engineered mutation |
Asp 164 | Ser 164 | engineered mutation |
Glu 170 | Thr 170 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42235.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 500.6 | |
All* | Total formula weight | 42736.3 |