8R9A
A soakable crystal form of human CDK7 in complex with AMP-PNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000307 | cellular_component | cyclin-dependent protein kinase holoenzyme complex |
| A | 0000439 | cellular_component | transcription factor TFIIH core complex |
| A | 0001650 | cellular_component | fibrillar center |
| A | 0001673 | cellular_component | male germ cell nucleus |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004693 | molecular_function | cyclin-dependent protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005675 | cellular_component | transcription factor TFIIH holo complex |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006281 | biological_process | DNA repair |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0006367 | biological_process | transcription initiation at RNA polymerase II promoter |
| A | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| A | 0008353 | molecular_function | RNA polymerase II CTD heptapeptide repeat kinase activity |
| A | 0016301 | molecular_function | kinase activity |
| A | 0042795 | biological_process | snRNA transcription by RNA polymerase II |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050821 | biological_process | protein stabilization |
| A | 0051301 | biological_process | cell division |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0070516 | cellular_component | CAK-ERCC2 complex |
| A | 0070985 | cellular_component | transcription factor TFIIK complex |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 2000045 | biological_process | regulation of G1/S transition of mitotic cell cycle |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK |
| Chain | Residue | Details |
| A | LEU18-LYS42 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL |
| Chain | Residue | Details |
| A | ILE133-LEU145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:15530371 |
| Chain | Residue | Details |
| A | ASP137 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:15530371 |
| Chain | Residue | Details |
| A | LEU18 | |
| A | LYS41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER7 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK1 and CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ASP164 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:15530371, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | GLU170 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER321 |
