8QYS
Human preholo proteasome 20S core particle
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, R (A, R) | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3 |
| 2 | B, S (B, S) | Proteasome subunit alpha type-4 | polymer | 248 | 27901.9 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L |
| 3 | C, T (C, T) | Proteasome subunit alpha type-7 | polymer | 234 | 26278.0 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7 |
| 4 | D, U (D, U) | Proteasome subunit alpha type-5 | polymer | 240 | 26322.8 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain |
| 5 | E, V (E, V) | Proteasome subunit alpha type-1 | polymer | 241 | 27164.0 | 2 | UniProt (P25786) Pfam (PF00227) Pfam (PF10584) | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain |
| 6 | F, W (F, W) | Proteasome subunit alpha type-3 | polymer | 241 | 26870.7 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8 |
| 7 | G, X (G, X) | Proteasome subunit alpha type-6 | polymer | 244 | 27160.2 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | 27 kDa prosomal protein,PROS-27,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain |
| 8 | H, Y (H, Y) | Proteasome maturation protein | polymer | 141 | 15805.0 | 2 | UniProt (Q9Y244) Pfam (PF05348) | Homo sapiens (human) | Proteassemblin,Protein UMP1 homolog,hUMP1,Voltage-gated K channel beta subunit 4.1 |
| 9 | I, Z (I, Z) | Proteasome assembly chaperone 1 | polymer | 288 | 32891.9 | 2 | UniProt (O95456) Pfam (PF16094) | Homo sapiens (human) | PAC-1,Chromosome 21 leucine-rich protein,C21-LRP,Down syndrome critical region protein 2 |
| 10 | AA, J (J, a) | Proteasome assembly chaperone 2 | polymer | 264 | 29423.0 | 2 | UniProt (Q969U7) Pfam (PF09754) | Homo sapiens (human) | PAC-2,Hepatocellular carcinoma-susceptibility protein 3,Tumor necrosis factor superfamily member 5-induced protein 1 |
| 11 | BA, K (K, b) | Proteasome subunit beta type-7 | polymer | 262 | 28292.5 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z |
| 12 | CA, L (L, c) | Proteasome subunit beta type-3 | polymer | 203 | 22754.6 | 2 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain |
| 13 | DA, M (M, d) | Proteasome subunit beta type-2 | polymer | 197 | 22462.8 | 2 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I |
| 14 | EA, N (N, e) | Proteasome subunit beta type-5 | polymer | 208 | 22978.0 | 2 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X |
| 15 | FA, O (O, f) | Proteasome subunit beta type-1 | polymer | 212 | 23421.8 | 2 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain |
| 16 | GA, P (P, g) | Proteasome subunit beta type-4 | polymer | 208 | 23159.3 | 2 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (human) | 26 kDa prosomal protein,HsBPROS26,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3 |
| 17 | HA, Q (Q, h) | Proteasome subunit beta type-6 | polymer | 197 | 21158.9 | 2 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (human) |
Sequence modifications
P, g: 50 - 257 (UniProt: P28070)
Q, h: 35 - 231 (UniProt: P28072)
| PDB | External Database | Details |
|---|---|---|
| Thr 234 | Ile 234 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly 145 | Val 145 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 34 |
| Total formula weight | 859946.1 | |
| All* | Total formula weight | 859946.1 |
