8QYS

Human preholo proteasome 20S core particle

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, R	Proteasome subunit alpha type-2	polymer	234	25927.5	2	UniProt (P25787) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (human)	Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
2	B, S	Proteasome subunit alpha type-4	polymer	248	27901.9	2	UniProt (P25789) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (human)	Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
3	C, T	Proteasome subunit alpha type-7	polymer	234	26278.0	2	UniProt (O14818) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (human)	Proteasome subunit RC6-1,Proteasome subunit XAPC7
4	D, U	Proteasome subunit alpha type-5	polymer	240	26322.8	2	UniProt (P28066) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (human)	Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
5	E, V	Proteasome subunit alpha type-1	polymer	241	27164.0	2	UniProt (P25786) Pfam (PF00227) Pfam (PF10584) In PDB	Homo sapiens (human)	30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
6	F, W	Proteasome subunit alpha type-3	polymer	241	26870.7	2	UniProt (P25788) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (human)	Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
7	G, X	Proteasome subunit alpha type-6	polymer	244	27160.2	2	UniProt (P60900) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (human)	27 kDa prosomal protein,PROS-27,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
8	H, Y	Proteasome maturation protein	polymer	141	15805.0	2	UniProt (Q9Y244) Pfam (PF05348) In PDB	Homo sapiens (human)	Proteassemblin,Protein UMP1 homolog,hUMP1,Voltage-gated K channel beta subunit 4.1
9	I, Z	Proteasome assembly chaperone 1	polymer	288	32891.9	2	UniProt (O95456) Pfam (PF16094) In PDB	Homo sapiens (human)	PAC-1,Chromosome 21 leucine-rich protein,C21-LRP,Down syndrome critical region protein 2
10	J, a	Proteasome assembly chaperone 2	polymer	264	29423.0	2	UniProt (Q969U7) Pfam (PF09754) In PDB	Homo sapiens (human)	PAC-2,Hepatocellular carcinoma-susceptibility protein 3,Tumor necrosis factor superfamily member 5-induced protein 1
11	K, b	Proteasome subunit beta type-7	polymer	262	28292.5	2	UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) In PDB	Homo sapiens (human)	Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
12	L, c	Proteasome subunit beta type-3	polymer	203	22754.6	2	UniProt (P49720) Pfam (PF00227) In PDB	Homo sapiens (human)	Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
13	M, d	Proteasome subunit beta type-2	polymer	197	22462.8	2	UniProt (P49721) Pfam (PF00227) In PDB	Homo sapiens (human)	Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
14	N, e	Proteasome subunit beta type-5	polymer	208	22978.0	2	UniProt (P28074) Pfam (PF00227) In PDB	Homo sapiens (human)	Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
15	O, f	Proteasome subunit beta type-1	polymer	212	23421.8	2	UniProt (P20618) Pfam (PF00227) In PDB	Homo sapiens (human)	Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
16	P, g	Proteasome subunit beta type-4	polymer	208	23159.3	2	UniProt (P28070) Pfam (PF00227) In PDB	Homo sapiens (human)	26 kDa prosomal protein,HsBPROS26,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3
17	Q, h	Proteasome subunit beta type-6	polymer	197	21158.9	2	UniProt (P28072) Pfam (PF00227) In PDB	Homo sapiens (human)

Sequence modifications

P, g: 50 - 257 (UniProt: P28070)

PDB	External Database	Details
Thr 234	Ile 234	variant

Q, h: 35 - 231 (UniProt: P28072)

PDB	External Database	Details
Gly 145	Val 145	variant

Contents of the asymmetric unit

Polymers	Number of chains	34
	Total formula weight	859946.1
All*	Total formula weight	859946.1

*Water molecules are not included.