8QM7

Potential drug binding sites for translation initiation factor eIF4E

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Eukaryotic translation initiation factor 4E	polymer	215	25014.4	2	UniProt (P06730) Pfam (PF01652)	Homo sapiens (human)
2	C, D, G (A, B)	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
3	E (A)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
4	F, I (A, B)	(2~{R})-2-[(1~{R})-1-[4-(2-fluorophenyl)-2-(2-hydroxyethylamino)phenyl]propoxy]propan-1-ol	non-polymer		347.4	2	Chemie (W5K)
5	H (B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
6	J, K (A, B)	water	water		18.0	197	Chemie (HOH)

Sequence modifications

A, B: 36 - 217 (UniProt: P06730)

PDB	External Database	Details
Met 3	-	initiating methionine
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Gly 10	-	expression tag
Ala 11	-	expression tag
Arg 12	-	expression tag
Ile 13	-	expression tag
Ile 14	-	expression tag
Tyr 15	-	expression tag
Asp 16	-	expression tag
Arg 17	-	expression tag
Ala 18	-	expression tag
Phe 19	-	expression tag
Leu 20	-	expression tag
Met 21	-	expression tag
Ala 22	-	expression tag
Cys 23	-	expression tag
Arg 24	-	expression tag
Gly 25	-	expression tag
Gly 26	-	expression tag
Gly 27	-	expression tag
Gly 28	-	expression tag
Glu 29	-	expression tag
Asn 30	-	expression tag
Leu 31	-	expression tag
Tyr 32	-	expression tag
Phe 33	-	expression tag
Gln 34	-	expression tag
Gly 35	-	expression tag
Asn 127	Asp 127	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50028.9
Non-Polymers*	Number of molecules	7
	Total formula weight	1185.5
All*	Total formula weight	51214.4

*Water molecules are not included.