8QM7
Potential drug binding sites for translation initiation factor eIF4E
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003743 | molecular_function | translation initiation factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006413 | biological_process | translational initiation |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC and MKNK2","evidences":[{"source":"PubMed","id":"11154262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25923732","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7665584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7782323","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
