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8Q7N

cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(5)
U5 snRNApolymer11737254.91GenBank (20330981)Homo sapiens (human)
2B
(6)
U6 snRNApolymer10634098.31GenBank (NR_004394.1)Homo sapiens (human)
3C
(7)
Splicing factor 3A subunit 1polymer79388991.11UniProt (Q15459)
Pfam (PF01805)
Pfam (PF12230)
Pfam (PF00240)
Homo sapiens (human)SF3a120,Spliceosome-associated protein 114,SAP 114
4D
(C)
116 kDa U5 small nuclear ribonucleoprotein componentpolymer972109560.61UniProt (Q15029)
Pfam (PF16004)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF14492)
Pfam (PF03764)
Pfam (PF00679)
Homo sapiens (human)Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa
5E
(D)
Thioredoxin-like protein 4Apolymer14216807.31UniProt (P83876)
Pfam (PF02966)
Homo sapiens (human)DIM1 protein homolog,Spliceosomal U5 snRNP-specific 15 kDa protein,Thioredoxin-like U5 snRNP protein U5-15kD
6F
(I)
Pre-mRNA-splicing factor 38Apolymer31237563.91UniProt (Q8NAV1)
Pfam (PF03371)
Pfam (PF12871)
Homo sapiens (human)
7G
(K)
Microfibrillar-associated protein 1polymer43952050.51UniProt (P55081)
Pfam (PF06991)
Homo sapiens (human)Spliceosome B complex protein MFAP1
8H
(M)
NHP2-like protein 1, N-terminally processedpolymer12814191.51UniProt (P55769)
Pfam (PF01248)
Homo sapiens (human)
9I
(Q)
Protein BUD31 homologpolymer14417032.81UniProt (P41223)
Pfam (PF01125)
Homo sapiens (human)Protein EDG-2,Protein G10 homolog
10J
(X)
WW domain-binding protein 4polymer37642575.81UniProt (O75554)
Pfam (PF06220)
Pfam (PF00397)
Homo sapiens (human)WBP-4,Formin-binding protein 21,WW domain-containing-binding protein 4
11K
(Z)
MINX pre-mRNApolymer347111300.51Homo sapiens
12L
(r)
Zinc finger matrin-type protein 2polymer19923664.01UniProt (Q96NC0)
Pfam (PF12171)
Homo sapiens (human)
13M
(s)
Ubiquitin-like protein 5polymer738560.91UniProt (Q9BZL1)
Pfam (PF00240)
Homo sapiens (human)
14N
(L)
U4/U6 small nuclear ribonucleoprotein Prp31polymer49955529.01UniProt (Q8WWY3)
Pfam (PF01798)
Pfam (PF09785)
Homo sapiens (human)Pre-mRNA-processing factor 31,Serologically defined breast cancer antigen NY-BR-99,U4/U6 snRNP 61 kDa protein,Protein 61K,hPrp31
15O
(F)
U4/U6 small nuclear ribonucleoprotein Prp4polymer52258536.11UniProt (O43172)
Pfam (PF08799)
Pfam (PF00400)
Homo sapiens (human)PRP4 homolog,hPrp4,U4/U6 snRNP 60 kDa protein,WD splicing factor Prp4
16P
(N)
Pre-mRNA-processing factor 6polymer941107092.21UniProt (O94906)
Pfam (PF06424)
Pfam (PF14559)
Pfam (PF13432)
Homo sapiens (human)Androgen receptor N-terminal domain-transactivating protein 1,ANT-1,PRP6 homolog,U5 snRNP-associated 102 kDa protein,U5-102 kDa protein
17Q
(A)
Pre-mRNA-processing-splicing factor 8polymer2335273974.31UniProt (Q6P2Q9)
Pfam (PF12134)
Pfam (PF01398)
Pfam (PF08084)
Pfam (PF08082)
Pfam (PF08083)
Pfam (PF10598)
Pfam (PF10597)
Pfam (PF10596)
Homo sapiens (human)220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220
18R
(S)
U4/U6.U5 tri-snRNP-associated protein 1polymer80090414.11UniProt (O43290)
Pfam (PF19252)
Pfam (PF03343)
Homo sapiens (human)SNU66 homolog,hSnu66,Squamous cell carcinoma antigen recognized by T-cells 1,SART-1,hSART-1,U4/U6.U5 tri-snRNP-associated 110 kDa protein
19S
(T)
Transcription elongation regulator 1polymer1098124083.01UniProt (O14776)
Pfam (PF00397)
Pfam (PF01846)
Homo sapiens (human)TATA box-binding protein-associated factor 2S,Transcription factor CA150
20T
(4)
U4 snRNApolymer14546528.51Homo sapiens
21U
(J)
U4/U6 small nuclear ribonucleoprotein Prp3polymer68377669.21UniProt (O43395)
Pfam (PF01480)
Pfam (PF08572)
Pfam (PF06544)
Homo sapiens (human)Pre-mRNA-splicing factor 3,hPrp3,U4/U6 snRNP 90 kDa protein
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains21
Total formula weight1427478.5
All*Total formula weight1427478.5
*Water molecules are not included.

227111

PDB entries from 2024-11-06

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