Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8Q7N

cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)

Functional Information from GO Data

Chain	GOid	namespace	contents
7	0000389	biological_process	mRNA 3'-splice site recognition
7	0000398	biological_process	mRNA splicing, via spliceosome
7	0003723	molecular_function	RNA binding
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005681	cellular_component	spliceosomal complex
7	0005684	cellular_component	U2-type spliceosomal complex
7	0005686	cellular_component	U2 snRNP
7	0006396	biological_process	RNA processing
7	0006397	biological_process	mRNA processing
7	0008380	biological_process	RNA splicing
7	0016607	cellular_component	nuclear speck
7	0045292	biological_process	mRNA cis splicing, via spliceosome
7	0071004	cellular_component	U2-type prespliceosome
7	0071005	cellular_component	U2-type precatalytic spliceosome
7	0071013	cellular_component	catalytic step 2 spliceosome
7	1903241	biological_process	U2-type prespliceosome assembly
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140492	molecular_function	metal-dependent deubiquitinase activity
A	1990904	cellular_component	ribonucleoprotein complex
C	0000166	molecular_function	nucleotide binding
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0015030	cellular_component	Cajal body
C	0016020	cellular_component	membrane
C	0016607	cellular_component	nuclear speck
C	0030623	molecular_function	U5 snRNA binding
C	0042220	biological_process	response to cocaine
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0071466	biological_process	cellular response to xenobiotic stimulus
D	0000245	biological_process	spliceosomal complex assembly
D	0000375	biological_process	RNA splicing, via transesterification reactions
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0005829	cellular_component	cytosol
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
D	0051301	biological_process	cell division
D	0071005	cellular_component	U2-type precatalytic spliceosome
F	0000375	biological_process	RNA splicing, via transesterification reactions
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0006396	biological_process	RNA processing
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0015030	cellular_component	Cajal body
F	0016607	cellular_component	nuclear speck
F	0017070	molecular_function	U6 snRNA binding
F	0030621	molecular_function	U4 snRNA binding
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071001	cellular_component	U4/U6 snRNP
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0097525	cellular_component	spliceosomal snRNP complex
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071011	cellular_component	precatalytic spliceosome
J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
J	0000375	biological_process	RNA splicing, via transesterification reactions
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0005829	cellular_component	cytosol
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0015030	cellular_component	Cajal body
J	0016607	cellular_component	nuclear speck
J	0032991	cellular_component	protein-containing complex
J	0042802	molecular_function	identical protein binding
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0071005	cellular_component	U2-type precatalytic spliceosome
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0001527	cellular_component	microfibril
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0005684	cellular_component	U2-type spliceosomal complex
K	0005813	cellular_component	centrosome
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0071005	cellular_component	U2-type precatalytic spliceosome
L	0000244	biological_process	spliceosomal tri-snRNP complex assembly
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005684	cellular_component	U2-type spliceosomal complex
L	0005687	cellular_component	U4 snRNP
L	0005690	cellular_component	U4atac snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0015030	cellular_component	Cajal body
L	0016607	cellular_component	nuclear speck
L	0030621	molecular_function	U4 snRNA binding
L	0030622	molecular_function	U4atac snRNA binding
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0042802	molecular_function	identical protein binding
L	0043021	molecular_function	ribonucleoprotein complex binding
L	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
L	0048254	biological_process	snoRNA localization
L	0070990	molecular_function	snRNP binding
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	0071011	cellular_component	precatalytic spliceosome
L	0071166	biological_process	ribonucleoprotein complex localization
L	0071339	cellular_component	MLL1 complex
L	0097526	cellular_component	spliceosomal tri-snRNP complex
L	1990904	cellular_component	ribonucleoprotein complex
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000492	biological_process	box C/D snoRNP assembly
M	0001651	cellular_component	dense fibrillar component
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0005690	cellular_component	U4atac snRNP
M	0005730	cellular_component	nucleolus
M	0006397	biological_process	mRNA processing
M	0007338	biological_process	single fertilization
M	0008380	biological_process	RNA splicing
M	0030490	biological_process	maturation of SSU-rRNA
M	0030515	molecular_function	snoRNA binding
M	0030621	molecular_function	U4 snRNA binding
M	0030622	molecular_function	U4atac snRNA binding
M	0031428	cellular_component	box C/D methylation guide snoRNP complex
M	0032040	cellular_component	small-subunit processome
M	0032991	cellular_component	protein-containing complex
M	0034511	molecular_function	U3 snoRNA binding
M	0034512	molecular_function	box C/D sno(s)RNA binding
M	0042254	biological_process	ribosome biogenesis
M	0042274	biological_process	ribosomal small subunit biogenesis
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0051117	molecular_function	ATPase binding
M	0071005	cellular_component	U2-type precatalytic spliceosome
M	0071011	cellular_component	precatalytic spliceosome
M	1990904	cellular_component	ribonucleoprotein complex
N	0000244	biological_process	spliceosomal tri-snRNP complex assembly
N	0000245	biological_process	spliceosomal complex assembly
N	0000375	biological_process	RNA splicing, via transesterification reactions
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0005682	cellular_component	U5 snRNP
N	0005813	cellular_component	centrosome
N	0005829	cellular_component	cytosol
N	0006396	biological_process	RNA processing
N	0006397	biological_process	mRNA processing
N	0006403	biological_process	RNA localization
N	0008380	biological_process	RNA splicing
N	0016020	cellular_component	membrane
N	0016607	cellular_component	nuclear speck
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0036064	cellular_component	ciliary basal body
N	0042802	molecular_function	identical protein binding
N	0043021	molecular_function	ribonucleoprotein complex binding
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
N	0071005	cellular_component	U2-type precatalytic spliceosome
N	0071013	cellular_component	catalytic step 2 spliceosome
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0000785	cellular_component	chromatin
Q	0003713	molecular_function	transcription coactivator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0005813	cellular_component	centrosome
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0015630	cellular_component	microtubule cytoskeleton
Q	0016922	molecular_function	nuclear receptor binding
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000481	biological_process	maturation of 5S rRNA
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005737	cellular_component	cytoplasm
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0015030	cellular_component	Cajal body
S	0016607	cellular_component	nuclear speck
S	0045292	biological_process	mRNA cis splicing, via spliceosome
S	0045585	biological_process	positive regulation of cytotoxic T cell differentiation
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
T	0000122	biological_process	negative regulation of transcription by RNA polymerase II
T	0003711	molecular_function	transcription elongation factor activity
T	0003712	molecular_function	transcription coregulator activity
T	0003713	molecular_function	transcription coactivator activity
T	0003714	molecular_function	transcription corepressor activity
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0016607	cellular_component	nuclear speck
T	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
T	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
T	0042802	molecular_function	identical protein binding
T	0044390	molecular_function	ubiquitin-like protein conjugating enzyme binding
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
T	0070063	molecular_function	RNA polymerase binding
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0003676	molecular_function	nucleic acid binding
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0006397	biological_process	mRNA processing
X	0008270	molecular_function	zinc ion binding
X	0008380	biological_process	RNA splicing
X	0016607	cellular_component	nuclear speck
X	0045292	biological_process	mRNA cis splicing, via spliceosome
X	0046872	molecular_function	metal ion binding
X	0070064	molecular_function	proline-rich region binding
X	0071005	cellular_component	U2-type precatalytic spliceosome
X	0071011	cellular_component	precatalytic spliceosome
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003676	molecular_function	nucleic acid binding
r	0003677	molecular_function	DNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0006397	biological_process	mRNA processing
r	0008270	molecular_function	zinc ion binding
r	0008380	biological_process	RNA splicing
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0046872	molecular_function	metal ion binding
r	0071005	cellular_component	U2-type precatalytic spliceosome
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005737	cellular_component	cytoplasm
s	0015030	cellular_component	Cajal body
s	0031386	molecular_function	protein tag activity
s	0036211	biological_process	protein modification process
s	1903955	biological_process	positive regulation of protein targeting to mitochondrion

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnv..CdcvVkdsinfldHingkkH

Chain	Residue	Details
r	CYS82-HIS104

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS

Chain	Residue	Details
F	THR323-SER334

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LGTTcyDrSWRLWDL

Chain	Residue	Details
F	LEU338-LEU352
F	ILE422-LEU436

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP

Chain	Residue	Details
Q	LEU100-PRO122

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CtHCGCRGCS

Chain	Residue	Details
Q	CYS134-SER143

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
M	CYS73-GLY90

site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. WteyktadgktyYYnnrtle.STWEKP

Chain	Residue	Details
T	TRP435-PRO460
X	TRP128-PRO153
X	TRP169-PRO194

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	15
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	178
Details	Region: {"description":"N-terminal protein interaction domain","evidences":[{"source":"PubMed","id":"26673105","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Region: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	32
Details	Region: {"description":"Important for U4 snRNA-binding","evidences":[{"source":"PubMed","id":"10545122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0T1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Region: {"description":"Interaction with AR","evidences":[{"source":"PubMed","id":"28076346","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	31
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	24
Details	Zinc finger: {"description":"Matrin-type"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	72
Details	Domain: {"description":"Ubiquitin-like"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	118
Details	Domain: {"description":"Nop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00690","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	34
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"12444105","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	3
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Site: {"description":"Interaction with U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	47
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	40
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	31
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	26
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	31
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	32
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	32
Details	Repeat: {"description":"HAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	32
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	32
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	32
Details	Repeat: {"description":"HAT 8"}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	32
Details	Repeat: {"description":"HAT 9"}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	273
Details	Region: {"description":"Linker"}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	13
Details	Region: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	253
Details	Region: {"description":"RNase H homology domain"}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9Z315","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	54
Details	Domain: {"description":"FF 2"}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	56
Details	Domain: {"description":"FF 4"}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	56
Details	Domain: {"description":"FF 5"}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	65
Details	Domain: {"description":"FF 6"}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	25
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)