8PR0
Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (D, C) | Cytoplasmic dynein 1 intermediate chain 2 | polymer | 612 | 68442.1 | 2 | UniProt (Q13409) Pfam (PF11540) Pfam (PF00400) | Homo sapiens (human) | Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2 |
| 2 | C, D (F, E) | Dynein light chain 1, cytoplasmic | polymer | 89 | 10381.9 | 2 | UniProt (P63167) Pfam (PF01221) | Homo sapiens (human) | 8 kDa dynein light chain,DLC8,Dynein light chain LC8-type 1,Protein inhibitor of neuronal nitric oxide synthase,PIN |
| 3 | E, F (G, H) | Dynein light chain Tctex-type 1 | polymer | 113 | 12462.0 | 2 | UniProt (P63172) Pfam (PF03645) | Homo sapiens (human) | Protein CW-1,T-complex testis-specific protein 1 homolog |
| 4 | G, H (I, J) | Dynactin subunit 1 | polymer | 1281 | 142015.5 | 2 | UniProt (A0A287B8J2) Pfam (PF01302) Pfam (PF12455) | Sus scrofa (pig) | 150 kDa dynein-associated polypeptide,p150-glued |
| 5 | I, J (B, A) | Cytoplasmic dynein 1 heavy chain 1 | polymer | 4646 | 533055.1 | 2 | UniProt (Q14204) Pfam (PF08385) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) Pfam (PF08393) Pfam (PF12774) Pfam (PF17852) Pfam (PF12775) Pfam (PF22597) Pfam (PF12780) Pfam (PF12777) Pfam (PF12781) | Homo sapiens (human) | Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic |
| 6 | K (K) | Cytoplasmic dynein 1 light intermediate chain 2 | polymer | 492 | 54173.2 | 1 | UniProt (O43237) Pfam (PF05783) | Homo sapiens (human) | Dynein light intermediate chain 2,cytosolic,LIC-2,LIC53/55 |
Sequence modifications
D, C: 1 - 612 (UniProt: Q13409)
B, A: 1 - 4646 (UniProt: Q14204)
| PDB | External Database | Details |
|---|---|---|
| Ser 484 | Thr 484 | conflict |
| Gly 499 | Asp 499 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 1567 | Arg 1567 | engineered mutation |
| Glu 1610 | Lys 1610 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 1586886.4 | |
| All* | Total formula weight | 1586886.4 |
