8PR0

Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001673	cellular_component	male germ cell nucleus
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005938	cellular_component	cell cortex
A	0007018	biological_process	microtubule-based movement
A	0007052	biological_process	mitotic spindle organization
A	0007097	biological_process	nuclear migration
A	0008090	biological_process	retrograde axonal transport
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0016020	cellular_component	membrane
A	0030175	cellular_component	filopodium
A	0030286	cellular_component	dynein complex
A	0031122	biological_process	cytoplasmic microtubule organization
A	0032388	biological_process	positive regulation of intracellular transport
A	0033962	biological_process	P-body assembly
A	0034063	biological_process	stress granule assembly
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0051293	biological_process	establishment of spindle localization
A	0051301	biological_process	cell division
A	0051959	molecular_function	dynein light intermediate chain binding
A	0060236	biological_process	regulation of mitotic spindle organization
A	0070062	cellular_component	extracellular exosome
A	0090235	biological_process	regulation of metaphase plate congression
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1904115	cellular_component	axon cytoplasm
A	1905832	biological_process	positive regulation of spindle assembly
B	0000166	molecular_function	nucleotide binding
B	0001673	cellular_component	male germ cell nucleus
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005868	cellular_component	cytoplasmic dynein complex
B	0005874	cellular_component	microtubule
B	0005881	cellular_component	cytoplasmic microtubule
B	0005938	cellular_component	cell cortex
B	0007018	biological_process	microtubule-based movement
B	0007052	biological_process	mitotic spindle organization
B	0007097	biological_process	nuclear migration
B	0008090	biological_process	retrograde axonal transport
B	0008569	molecular_function	minus-end-directed microtubule motor activity
B	0016020	cellular_component	membrane
B	0030175	cellular_component	filopodium
B	0030286	cellular_component	dynein complex
B	0031122	biological_process	cytoplasmic microtubule organization
B	0032388	biological_process	positive regulation of intracellular transport
B	0033962	biological_process	P-body assembly
B	0034063	biological_process	stress granule assembly
B	0035578	cellular_component	azurophil granule lumen
B	0042802	molecular_function	identical protein binding
B	0045505	molecular_function	dynein intermediate chain binding
B	0051293	biological_process	establishment of spindle localization
B	0051301	biological_process	cell division
B	0051959	molecular_function	dynein light intermediate chain binding
B	0060236	biological_process	regulation of mitotic spindle organization
B	0070062	cellular_component	extracellular exosome
B	0090235	biological_process	regulation of metaphase plate congression
B	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	1904115	cellular_component	axon cytoplasm
B	1905832	biological_process	positive regulation of spindle assembly
C	0001673	cellular_component	male germ cell nucleus
C	0003777	molecular_function	microtubule motor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005874	cellular_component	microtubule
C	0007018	biological_process	microtubule-based movement
C	0010970	biological_process	transport along microtubule
C	0030286	cellular_component	dynein complex
C	0031982	cellular_component	vesicle
C	0032388	biological_process	positive regulation of intracellular transport
C	0045503	molecular_function	dynein light chain binding
C	0045504	molecular_function	dynein heavy chain binding
C	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
D	0001673	cellular_component	male germ cell nucleus
D	0003777	molecular_function	microtubule motor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005868	cellular_component	cytoplasmic dynein complex
D	0005874	cellular_component	microtubule
D	0007018	biological_process	microtubule-based movement
D	0010970	biological_process	transport along microtubule
D	0030286	cellular_component	dynein complex
D	0031982	cellular_component	vesicle
D	0032388	biological_process	positive regulation of intracellular transport
D	0045503	molecular_function	dynein light chain binding
D	0045504	molecular_function	dynein heavy chain binding
D	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
E	0000776	cellular_component	kinetochore
E	0001673	cellular_component	male germ cell nucleus
E	0004857	molecular_function	enzyme inhibitor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0005875	cellular_component	microtubule associated complex
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0006351	biological_process	DNA-templated transcription
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0007017	biological_process	microtubule-based process
E	0007286	biological_process	spermatid development
E	0008180	cellular_component	COP9 signalosome
E	0015630	cellular_component	microtubule cytoskeleton
E	0016020	cellular_component	membrane
E	0019899	molecular_function	enzyme binding
E	0021762	biological_process	substantia nigra development
E	0030141	cellular_component	secretory granule
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030286	cellular_component	dynein complex
E	0032388	biological_process	positive regulation of intracellular transport
E	0035721	biological_process	intraciliary retrograde transport
E	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
E	0035861	cellular_component	site of double-strand break
E	0036487	molecular_function	nitric-oxide synthase inhibitor activity
E	0042326	biological_process	negative regulation of phosphorylation
E	0042802	molecular_function	identical protein binding
E	0044458	biological_process	motile cilium assembly
E	0044877	molecular_function	protein-containing complex binding
E	0045505	molecular_function	dynein intermediate chain binding
E	0070821	cellular_component	tertiary granule membrane
E	0072686	cellular_component	mitotic spindle
E	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
E	0097110	molecular_function	scaffold protein binding
E	0097542	cellular_component	ciliary tip
E	0101003	cellular_component	ficolin-1-rich granule membrane
E	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
E	1904115	cellular_component	axon cytoplasm
F	0000776	cellular_component	kinetochore
F	0001673	cellular_component	male germ cell nucleus
F	0004857	molecular_function	enzyme inhibitor activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005868	cellular_component	cytoplasmic dynein complex
F	0005874	cellular_component	microtubule
F	0005875	cellular_component	microtubule associated complex
F	0005886	cellular_component	plasma membrane
F	0005929	cellular_component	cilium
F	0006351	biological_process	DNA-templated transcription
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0007017	biological_process	microtubule-based process
F	0007286	biological_process	spermatid development
F	0008180	cellular_component	COP9 signalosome
F	0015630	cellular_component	microtubule cytoskeleton
F	0016020	cellular_component	membrane
F	0019899	molecular_function	enzyme binding
F	0021762	biological_process	substantia nigra development
F	0030141	cellular_component	secretory granule
F	0030235	molecular_function	nitric-oxide synthase regulator activity
F	0030286	cellular_component	dynein complex
F	0032388	biological_process	positive regulation of intracellular transport
F	0035721	biological_process	intraciliary retrograde transport
F	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
F	0035861	cellular_component	site of double-strand break
F	0036487	molecular_function	nitric-oxide synthase inhibitor activity
F	0042326	biological_process	negative regulation of phosphorylation
F	0042802	molecular_function	identical protein binding
F	0044458	biological_process	motile cilium assembly
F	0044877	molecular_function	protein-containing complex binding
F	0045505	molecular_function	dynein intermediate chain binding
F	0070821	cellular_component	tertiary granule membrane
F	0072686	cellular_component	mitotic spindle
F	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
F	0097110	molecular_function	scaffold protein binding
F	0097542	cellular_component	ciliary tip
F	0101003	cellular_component	ficolin-1-rich granule membrane
F	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
F	1904115	cellular_component	axon cytoplasm
G	0000132	biological_process	establishment of mitotic spindle orientation
G	0001673	cellular_component	male germ cell nucleus
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005794	cellular_component	Golgi apparatus
G	0005819	cellular_component	spindle
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005929	cellular_component	cilium
G	0007018	biological_process	microtubule-based movement
G	0007399	biological_process	nervous system development
G	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
G	0019060	biological_process	intracellular transport of viral protein in host cell
G	0030286	cellular_component	dynein complex
G	0032388	biological_process	positive regulation of intracellular transport
G	0034774	cellular_component	secretory granule lumen
G	0035721	biological_process	intraciliary retrograde transport
G	0042802	molecular_function	identical protein binding
G	0043657	cellular_component	host cell
G	0045505	molecular_function	dynein intermediate chain binding
G	0046718	biological_process	symbiont entry into host cell
G	0050768	biological_process	negative regulation of neurogenesis
G	0051301	biological_process	cell division
G	0075521	biological_process	microtubule-dependent intracellular transport of viral material towards nucleus
G	0075606	biological_process	transport of viral material towards nucleus
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	0099503	cellular_component	secretory vesicle
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000132	biological_process	establishment of mitotic spindle orientation
H	0001673	cellular_component	male germ cell nucleus
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005819	cellular_component	spindle
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0005929	cellular_component	cilium
H	0007018	biological_process	microtubule-based movement
H	0007399	biological_process	nervous system development
H	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
H	0019060	biological_process	intracellular transport of viral protein in host cell
H	0030286	cellular_component	dynein complex
H	0032388	biological_process	positive regulation of intracellular transport
H	0034774	cellular_component	secretory granule lumen
H	0035721	biological_process	intraciliary retrograde transport
H	0042802	molecular_function	identical protein binding
H	0043657	cellular_component	host cell
H	0045505	molecular_function	dynein intermediate chain binding
H	0046718	biological_process	symbiont entry into host cell
H	0050768	biological_process	negative regulation of neurogenesis
H	0051301	biological_process	cell division
H	0075521	biological_process	microtubule-dependent intracellular transport of viral material towards nucleus
H	0075606	biological_process	transport of viral material towards nucleus
H	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
H	0099503	cellular_component	secretory vesicle
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0000132	biological_process	establishment of mitotic spindle orientation
I	0000776	cellular_component	kinetochore
I	0000922	cellular_component	spindle pole
I	0005635	cellular_component	nuclear envelope
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005814	cellular_component	centriole
I	0005819	cellular_component	spindle
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0005875	cellular_component	microtubule associated complex
I	0005938	cellular_component	cell cortex
I	0007017	biological_process	microtubule-based process
I	0007077	biological_process	mitotic nuclear membrane disassembly
I	0007097	biological_process	nuclear migration
I	0007528	biological_process	neuromuscular junction development
I	0008017	molecular_function	microtubule binding
I	0010008	cellular_component	endosome membrane
I	0010457	biological_process	centriole-centriole cohesion
I	0015630	cellular_component	microtubule cytoskeleton
I	0015631	molecular_function	tubulin binding
I	0019901	molecular_function	protein kinase binding
I	0021517	biological_process	ventral spinal cord development
I	0030286	cellular_component	dynein complex
I	0030424	cellular_component	axon
I	0030904	cellular_component	retromer complex
I	0031116	biological_process	positive regulation of microtubule polymerization
I	0031252	cellular_component	cell leading edge
I	0032935	molecular_function	sterol sensor activity
I	0032991	cellular_component	protein-containing complex
I	0034454	biological_process	microtubule anchoring at centrosome
I	0035371	cellular_component	microtubule plus-end
I	0036064	cellular_component	ciliary basal body
I	0042147	biological_process	retrograde transport, endosome to Golgi
I	0042632	biological_process	cholesterol homeostasis
I	0043005	cellular_component	neuron projection
I	0043025	cellular_component	neuronal cell body
I	0045171	cellular_component	intercellular bridge
I	0050905	biological_process	neuromuscular process
I	0051301	biological_process	cell division
I	0060236	biological_process	regulation of mitotic spindle organization
I	0061744	biological_process	motor behavior
I	0070050	biological_process	neuron cellular homeostasis
I	0090063	biological_process	positive regulation of microtubule nucleation
I	0090120	biological_process	lysosome to ER cholesterol transport
I	0120103	cellular_component	centriolar subdistal appendage
I	1904398	biological_process	positive regulation of neuromuscular junction development
I	1905515	biological_process	non-motile cilium assembly
I	1990535	biological_process	neuron projection maintenance
J	0000132	biological_process	establishment of mitotic spindle orientation
J	0000776	cellular_component	kinetochore
J	0000922	cellular_component	spindle pole
J	0005635	cellular_component	nuclear envelope
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005814	cellular_component	centriole
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005875	cellular_component	microtubule associated complex
J	0005938	cellular_component	cell cortex
J	0007017	biological_process	microtubule-based process
J	0007077	biological_process	mitotic nuclear membrane disassembly
J	0007097	biological_process	nuclear migration
J	0007528	biological_process	neuromuscular junction development
J	0008017	molecular_function	microtubule binding
J	0010008	cellular_component	endosome membrane
J	0010457	biological_process	centriole-centriole cohesion
J	0015630	cellular_component	microtubule cytoskeleton
J	0015631	molecular_function	tubulin binding
J	0019901	molecular_function	protein kinase binding
J	0021517	biological_process	ventral spinal cord development
J	0030286	cellular_component	dynein complex
J	0030424	cellular_component	axon
J	0030904	cellular_component	retromer complex
J	0031116	biological_process	positive regulation of microtubule polymerization
J	0031252	cellular_component	cell leading edge
J	0032935	molecular_function	sterol sensor activity
J	0032991	cellular_component	protein-containing complex
J	0034454	biological_process	microtubule anchoring at centrosome
J	0035371	cellular_component	microtubule plus-end
J	0036064	cellular_component	ciliary basal body
J	0042147	biological_process	retrograde transport, endosome to Golgi
J	0042632	biological_process	cholesterol homeostasis
J	0043005	cellular_component	neuron projection
J	0043025	cellular_component	neuronal cell body
J	0045171	cellular_component	intercellular bridge
J	0050905	biological_process	neuromuscular process
J	0051301	biological_process	cell division
J	0060236	biological_process	regulation of mitotic spindle organization
J	0061744	biological_process	motor behavior
J	0070050	biological_process	neuron cellular homeostasis
J	0090063	biological_process	positive regulation of microtubule nucleation
J	0090120	biological_process	lysosome to ER cholesterol transport
J	0120103	cellular_component	centriolar subdistal appendage
J	1904398	biological_process	positive regulation of neuromuscular junction development
J	1905515	biological_process	non-motile cilium assembly
J	1990535	biological_process	neuron projection maintenance
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000776	cellular_component	kinetochore
K	0001673	cellular_component	male germ cell nucleus
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005770	cellular_component	late endosome
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005868	cellular_component	cytoplasmic dynein complex
K	0005874	cellular_component	microtubule
K	0007018	biological_process	microtubule-based movement
K	0016020	cellular_component	membrane
K	0030286	cellular_component	dynein complex
K	0032388	biological_process	positive regulation of intracellular transport
K	0042802	molecular_function	identical protein binding
K	0045504	molecular_function	dynein heavy chain binding
K	1990090	biological_process	cellular response to nerve growth factor stimulus

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
B	ILE2216-SER2226

---

site_id	PS00845
Number of Residues	32
Details	CAP_GLY_1 CAP-Gly domain signature. Gatlfatgk..WvGVilDeak....GKNdGTvqGrkYF

Chain	Residue	Details
I	GLY48-PHE79

---

site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
F	HIS55-GLU69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Region: {"description":"Interaction with ESR1","evidences":[{"source":"PubMed","id":"15891768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15193260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30464262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37696958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	144
Details	Region: {"description":"Interaction with GNB1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	194
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9JHU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---