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8PR0

Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005868cellular_componentcytoplasmic dynein complex
A0005874cellular_componentmicrotubule
A0005881cellular_componentcytoplasmic microtubule
A0005938cellular_componentcell cortex
A0007018biological_processmicrotubule-based movement
A0007052biological_processmitotic spindle organization
A0007097biological_processnuclear migration
A0008090biological_processretrograde axonal transport
A0008569molecular_functionminus-end-directed microtubule motor activity
A0016020cellular_componentmembrane
A0030175cellular_componentfilopodium
A0030286cellular_componentdynein complex
A0031122biological_processcytoplasmic microtubule organization
A0032388biological_processpositive regulation of intracellular transport
A0033962biological_processP-body assembly
A0034063biological_processstress granule assembly
A0035578cellular_componentazurophil granule lumen
A0042802molecular_functionidentical protein binding
A0045505molecular_functiondynein intermediate chain binding
A0051293biological_processestablishment of spindle localization
A0051301biological_processcell division
A0051959molecular_functiondynein light intermediate chain binding
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0090235biological_processregulation of metaphase plate congression
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904115cellular_componentaxon cytoplasm
A1905832biological_processpositive regulation of spindle assembly
B0000166molecular_functionnucleotide binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005868cellular_componentcytoplasmic dynein complex
B0005874cellular_componentmicrotubule
B0005881cellular_componentcytoplasmic microtubule
B0005938cellular_componentcell cortex
B0007018biological_processmicrotubule-based movement
B0007052biological_processmitotic spindle organization
B0007097biological_processnuclear migration
B0008090biological_processretrograde axonal transport
B0008569molecular_functionminus-end-directed microtubule motor activity
B0016020cellular_componentmembrane
B0030175cellular_componentfilopodium
B0030286cellular_componentdynein complex
B0031122biological_processcytoplasmic microtubule organization
B0032388biological_processpositive regulation of intracellular transport
B0033962biological_processP-body assembly
B0034063biological_processstress granule assembly
B0035578cellular_componentazurophil granule lumen
B0042802molecular_functionidentical protein binding
B0045505molecular_functiondynein intermediate chain binding
B0051293biological_processestablishment of spindle localization
B0051301biological_processcell division
B0051959molecular_functiondynein light intermediate chain binding
B0060236biological_processregulation of mitotic spindle organization
B0070062cellular_componentextracellular exosome
B0090235biological_processregulation of metaphase plate congression
B0120162biological_processpositive regulation of cold-induced thermogenesis
B1904115cellular_componentaxon cytoplasm
B1905832biological_processpositive regulation of spindle assembly
C0003777molecular_functionmicrotubule motor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005868cellular_componentcytoplasmic dynein complex
C0005874cellular_componentmicrotubule
C0007018biological_processmicrotubule-based movement
C0010970biological_processtransport along microtubule
C0030286cellular_componentdynein complex
C0031982cellular_componentvesicle
C0032388biological_processpositive regulation of intracellular transport
C0045503molecular_functiondynein light chain binding
C0045504molecular_functiondynein heavy chain binding
D0003777molecular_functionmicrotubule motor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005868cellular_componentcytoplasmic dynein complex
D0005874cellular_componentmicrotubule
D0007018biological_processmicrotubule-based movement
D0010970biological_processtransport along microtubule
D0030286cellular_componentdynein complex
D0031982cellular_componentvesicle
D0032388biological_processpositive regulation of intracellular transport
D0045503molecular_functiondynein light chain binding
D0045504molecular_functiondynein heavy chain binding
E0000776cellular_componentkinetochore
E0004857molecular_functionenzyme inhibitor activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005694cellular_componentchromosome
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005813cellular_componentcentrosome
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005868cellular_componentcytoplasmic dynein complex
E0005874cellular_componentmicrotubule
E0005875cellular_componentmicrotubule associated complex
E0005886cellular_componentplasma membrane
E0005929cellular_componentcilium
E0006915biological_processapoptotic process
E0006974biological_processDNA damage response
E0007017biological_processmicrotubule-based process
E0007286biological_processspermatid development
E0008180cellular_componentCOP9 signalosome
E0015630cellular_componentmicrotubule cytoskeleton
E0016020cellular_componentmembrane
E0019899molecular_functionenzyme binding
E0021762biological_processsubstantia nigra development
E0030141cellular_componentsecretory granule
E0030235molecular_functionnitric-oxide synthase regulator activity
E0030286cellular_componentdynein complex
E0032388biological_processpositive regulation of intracellular transport
E0035721biological_processintraciliary retrograde transport
E0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
E0035861cellular_componentsite of double-strand break
E0036487molecular_functionnitric-oxide synthase inhibitor activity
E0042326biological_processnegative regulation of phosphorylation
E0042802molecular_functionidentical protein binding
E0044458biological_processmotile cilium assembly
E0044877molecular_functionprotein-containing complex binding
E0045019biological_processnegative regulation of nitric oxide biosynthetic process
E0045505molecular_functiondynein intermediate chain binding
E0060703molecular_functiondeoxyribonuclease inhibitor activity
E0070821cellular_componenttertiary granule membrane
E0072686cellular_componentmitotic spindle
E0097110molecular_functionscaffold protein binding
E0097542cellular_componentciliary tip
E0101003cellular_componentficolin-1-rich granule membrane
E0110025biological_processDNA strand resection involved in replication fork processing
E0110027biological_processnegative regulation of DNA strand resection involved in replication fork processing
E1904115cellular_componentaxon cytoplasm
F0000776cellular_componentkinetochore
F0004857molecular_functionenzyme inhibitor activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005868cellular_componentcytoplasmic dynein complex
F0005874cellular_componentmicrotubule
F0005875cellular_componentmicrotubule associated complex
F0005886cellular_componentplasma membrane
F0005929cellular_componentcilium
F0006915biological_processapoptotic process
F0006974biological_processDNA damage response
F0007017biological_processmicrotubule-based process
F0007286biological_processspermatid development
F0008180cellular_componentCOP9 signalosome
F0015630cellular_componentmicrotubule cytoskeleton
F0016020cellular_componentmembrane
F0019899molecular_functionenzyme binding
F0021762biological_processsubstantia nigra development
F0030141cellular_componentsecretory granule
F0030235molecular_functionnitric-oxide synthase regulator activity
F0030286cellular_componentdynein complex
F0032388biological_processpositive regulation of intracellular transport
F0035721biological_processintraciliary retrograde transport
F0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
F0035861cellular_componentsite of double-strand break
F0036487molecular_functionnitric-oxide synthase inhibitor activity
F0042326biological_processnegative regulation of phosphorylation
F0042802molecular_functionidentical protein binding
F0044458biological_processmotile cilium assembly
F0044877molecular_functionprotein-containing complex binding
F0045019biological_processnegative regulation of nitric oxide biosynthetic process
F0045505molecular_functiondynein intermediate chain binding
F0060703molecular_functiondeoxyribonuclease inhibitor activity
F0070821cellular_componenttertiary granule membrane
F0072686cellular_componentmitotic spindle
F0097110molecular_functionscaffold protein binding
F0097542cellular_componentciliary tip
F0101003cellular_componentficolin-1-rich granule membrane
F0110025biological_processDNA strand resection involved in replication fork processing
F0110027biological_processnegative regulation of DNA strand resection involved in replication fork processing
F1904115cellular_componentaxon cytoplasm
G0000132biological_processestablishment of mitotic spindle orientation
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005737cellular_componentcytoplasm
G0005794cellular_componentGolgi apparatus
G0005819cellular_componentspindle
G0005856cellular_componentcytoskeleton
G0005868cellular_componentcytoplasmic dynein complex
G0005874cellular_componentmicrotubule
G0005881cellular_componentcytoplasmic microtubule
G0007018biological_processmicrotubule-based movement
G0007399biological_processnervous system development
G0008277biological_processregulation of G protein-coupled receptor signaling pathway
G0019060biological_processintracellular transport of viral protein in host cell
G0030286cellular_componentdynein complex
G0032388biological_processpositive regulation of intracellular transport
G0034774cellular_componentsecretory granule lumen
G0042802molecular_functionidentical protein binding
G0043657cellular_componenthost cell
G0045505molecular_functiondynein intermediate chain binding
G0046718biological_processsymbiont entry into host cell
G0050768biological_processnegative regulation of neurogenesis
G0051301biological_processcell division
G0075521biological_processmicrotubule-dependent intracellular transport of viral material towards nucleus
G0075606biological_processtransport of viral material towards nucleus
G0099503cellular_componentsecretory vesicle
G1904813cellular_componentficolin-1-rich granule lumen
H0000132biological_processestablishment of mitotic spindle orientation
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005737cellular_componentcytoplasm
H0005794cellular_componentGolgi apparatus
H0005819cellular_componentspindle
H0005856cellular_componentcytoskeleton
H0005868cellular_componentcytoplasmic dynein complex
H0005874cellular_componentmicrotubule
H0005881cellular_componentcytoplasmic microtubule
H0007018biological_processmicrotubule-based movement
H0007399biological_processnervous system development
H0008277biological_processregulation of G protein-coupled receptor signaling pathway
H0019060biological_processintracellular transport of viral protein in host cell
H0030286cellular_componentdynein complex
H0032388biological_processpositive regulation of intracellular transport
H0034774cellular_componentsecretory granule lumen
H0042802molecular_functionidentical protein binding
H0043657cellular_componenthost cell
H0045505molecular_functiondynein intermediate chain binding
H0046718biological_processsymbiont entry into host cell
H0050768biological_processnegative regulation of neurogenesis
H0051301biological_processcell division
H0075521biological_processmicrotubule-dependent intracellular transport of viral material towards nucleus
H0075606biological_processtransport of viral material towards nucleus
H0099503cellular_componentsecretory vesicle
H1904813cellular_componentficolin-1-rich granule lumen
I0000132biological_processestablishment of mitotic spindle orientation
I0000776cellular_componentkinetochore
I0000922cellular_componentspindle pole
I0005634cellular_componentnucleus
I0005635cellular_componentnuclear envelope
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005814cellular_componentcentriole
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005874cellular_componentmicrotubule
I0005875cellular_componentmicrotubule associated complex
I0005929cellular_componentcilium
I0005938cellular_componentcell cortex
I0007097biological_processnuclear migration
I0007528biological_processneuromuscular junction development
I0008017molecular_functionmicrotubule binding
I0010457biological_processcentriole-centriole cohesion
I0015630cellular_componentmicrotubule cytoskeleton
I0015631molecular_functiontubulin binding
I0019901molecular_functionprotein kinase binding
I0021517biological_processventral spinal cord development
I0030286cellular_componentdynein complex
I0030424cellular_componentaxon
I0030904cellular_componentretromer complex
I0031116biological_processpositive regulation of microtubule polymerization
I0031252cellular_componentcell leading edge
I0032402biological_processmelanosome transport
I0032991cellular_componentprotein-containing complex
I0034454biological_processmicrotubule anchoring at centrosome
I0035371cellular_componentmicrotubule plus-end
I0036064cellular_componentciliary basal body
I0042147biological_processretrograde transport, endosome to Golgi
I0043005cellular_componentneuron projection
I0043025cellular_componentneuronal cell body
I0045171cellular_componentintercellular bridge
I0050905biological_processneuromuscular process
I0051081biological_processnuclear membrane disassembly
I0051301biological_processcell division
I0060236biological_processregulation of mitotic spindle organization
I0061744biological_processmotor behavior
I0070050biological_processneuron cellular homeostasis
I0072686cellular_componentmitotic spindle
I0090063biological_processpositive regulation of microtubule nucleation
I0120103cellular_componentcentriolar subdistal appendage
I1904398biological_processpositive regulation of neuromuscular junction development
I1905515biological_processnon-motile cilium assembly
I1990535biological_processneuron projection maintenance
J0000132biological_processestablishment of mitotic spindle orientation
J0000776cellular_componentkinetochore
J0000922cellular_componentspindle pole
J0005634cellular_componentnucleus
J0005635cellular_componentnuclear envelope
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005814cellular_componentcentriole
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005874cellular_componentmicrotubule
J0005875cellular_componentmicrotubule associated complex
J0005929cellular_componentcilium
J0005938cellular_componentcell cortex
J0007097biological_processnuclear migration
J0007528biological_processneuromuscular junction development
J0008017molecular_functionmicrotubule binding
J0010457biological_processcentriole-centriole cohesion
J0015630cellular_componentmicrotubule cytoskeleton
J0015631molecular_functiontubulin binding
J0019901molecular_functionprotein kinase binding
J0021517biological_processventral spinal cord development
J0030286cellular_componentdynein complex
J0030424cellular_componentaxon
J0030904cellular_componentretromer complex
J0031116biological_processpositive regulation of microtubule polymerization
J0031252cellular_componentcell leading edge
J0032402biological_processmelanosome transport
J0032991cellular_componentprotein-containing complex
J0034454biological_processmicrotubule anchoring at centrosome
J0035371cellular_componentmicrotubule plus-end
J0036064cellular_componentciliary basal body
J0042147biological_processretrograde transport, endosome to Golgi
J0043005cellular_componentneuron projection
J0043025cellular_componentneuronal cell body
J0045171cellular_componentintercellular bridge
J0050905biological_processneuromuscular process
J0051081biological_processnuclear membrane disassembly
J0051301biological_processcell division
J0060236biological_processregulation of mitotic spindle organization
J0061744biological_processmotor behavior
J0070050biological_processneuron cellular homeostasis
J0072686cellular_componentmitotic spindle
J0090063biological_processpositive regulation of microtubule nucleation
J0120103cellular_componentcentriolar subdistal appendage
J1904398biological_processpositive regulation of neuromuscular junction development
J1905515biological_processnon-motile cilium assembly
J1990535biological_processneuron projection maintenance
K0000166molecular_functionnucleotide binding
K0000226biological_processmicrotubule cytoskeleton organization
K0000776cellular_componentkinetochore
K0005524molecular_functionATP binding
K0005737cellular_componentcytoplasm
K0005770cellular_componentlate endosome
K0005813cellular_componentcentrosome
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005868cellular_componentcytoplasmic dynein complex
K0005874cellular_componentmicrotubule
K0007018biological_processmicrotubule-based movement
K0016020cellular_componentmembrane
K0030286cellular_componentdynein complex
K0032388biological_processpositive regulation of intracellular transport
K0042802molecular_functionidentical protein binding
K0045504molecular_functiondynein heavy chain binding
K0051642biological_processcentrosome localization
K1990090biological_processcellular response to nerve growth factor stimulus
Functional Information from PROSITE/UniProt
site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS
ChainResidueDetails
BILE2216-SER2226

site_idPS00845
Number of Residues32
DetailsCAP_GLY_1 CAP-Gly domain signature. Gatlfatgk..WvGVilDeak....GKNdGTvqGrkYF
ChainResidueDetails
IGLY48-PHE79

site_idPS01239
Number of Residues15
DetailsDYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE
ChainResidueDetails
FHIS55-GLU69

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
KGLY61
BGLY2224
BGLY2595
BGLY2937
AGLY1906
AGLY2224
AGLY2595
AGLY2937

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
KSER194
ASER2
JSER179
JSER212

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
KSER383
BSER4162
ASER70
ASER4162

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
KSER391
BLYS3480
BLYS4283
ALYS1125
ALYS3480
ALYS4283

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
KARG397
ASER1230

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
KTHR441
ATHR4366

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
KSER443
ASER4368

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
KSER446

237423

PDB entries from 2025-06-11

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