8PQZ

Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, J (A, J)	Cytoplasmic dynein 1 heavy chain 1	polymer	4646	533055.1	2	UniProt (Q14204) Pfam (PF08385) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) Pfam (PF08393) Pfam (PF12774) Pfam (PF17852) Pfam (PF12775) Pfam (PF22597) Pfam (PF12780) Pfam (PF12777) Pfam (PF12781)	Homo sapiens (human)	Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic
2	B, C, D, E, K... (B, C, D, E, K...)	Platelet-activating factor acetylhydrolase IB subunit beta	polymer	410	46710.0	6	UniProt (P43034) Pfam (PF08513) Pfam (PF00400)	Homo sapiens (human)	Lissencephaly-1 protein,LIS-1,PAF acetylhydrolase 45 kDa subunit,PAF-AH 45 kDa subunit,PAF-AH alpha,PAFAH alpha
3	F, G (F, G)	Dynactin subunit 1	polymer	1281	142015.5	2	UniProt (A0A287B8J2) Pfam (PF01302) Pfam (PF12455)	Sus scrofa (pig)	150 kDa dynein-associated polypeptide,p150-glued
4	H, I (H, I)	Cytoplasmic dynein 1 intermediate chain 2	polymer	612	68442.1	2	UniProt (Q13409) Pfam (PF11540) Pfam (PF00400)	Homo sapiens (human)	Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2
5	M, Q, R, S, W... (A, J)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	6	Chemie (ADP)
6	N, P, T, V (A, J)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
7	O, U (A, J)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

A, J: 1 - 4646 (UniProt: Q14204)

PDB	External Database	Details
Glu 1567	Arg 1567	engineered mutation
Glu 1610	Lys 1610	engineered mutation

H, I: 1 - 612 (UniProt: Q13409)

PDB	External Database	Details
Ser 484	Thr 484	conflict
Gly 499	Asp 499	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	1767285.4
Non-Polymers*	Number of molecules	12
	Total formula weight	3674.8
All*	Total formula weight	1770960.2

*Water molecules are not included.