8PQZ

Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001673	cellular_component	male germ cell nucleus
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005938	cellular_component	cell cortex
A	0007018	biological_process	microtubule-based movement
A	0007052	biological_process	mitotic spindle organization
A	0007097	biological_process	nuclear migration
A	0008090	biological_process	retrograde axonal transport
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0016020	cellular_component	membrane
A	0030175	cellular_component	filopodium
A	0030286	cellular_component	dynein complex
A	0031122	biological_process	cytoplasmic microtubule organization
A	0032388	biological_process	positive regulation of intracellular transport
A	0033962	biological_process	P-body assembly
A	0034063	biological_process	stress granule assembly
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0051293	biological_process	establishment of spindle localization
A	0051301	biological_process	cell division
A	0051959	molecular_function	dynein light intermediate chain binding
A	0060236	biological_process	regulation of mitotic spindle organization
A	0070062	cellular_component	extracellular exosome
A	0090235	biological_process	regulation of metaphase plate congression
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1904115	cellular_component	axon cytoplasm
A	1905832	biological_process	positive regulation of spindle assembly
B	0000132	biological_process	establishment of mitotic spindle orientation
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000235	cellular_component	astral microtubule
B	0000776	cellular_component	kinetochore
B	0001675	biological_process	acrosome assembly
B	0001764	biological_process	neuron migration
B	0005515	molecular_function	protein binding
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005871	cellular_component	kinesin complex
B	0005874	cellular_component	microtubule
B	0005875	cellular_component	microtubule associated complex
B	0005881	cellular_component	cytoplasmic microtubule
B	0005938	cellular_component	cell cortex
B	0006629	biological_process	lipid metabolic process
B	0007017	biological_process	microtubule-based process
B	0007097	biological_process	nuclear migration
B	0007268	biological_process	chemical synaptic transmission
B	0007281	biological_process	germ cell development
B	0007399	biological_process	nervous system development
B	0007405	biological_process	neuroblast proliferation
B	0007611	biological_process	learning or memory
B	0008017	molecular_function	microtubule binding
B	0008090	biological_process	retrograde axonal transport
B	0008201	molecular_function	heparin binding
B	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
B	0008344	biological_process	adult locomotory behavior
B	0010977	biological_process	negative regulation of neuron projection development
B	0015630	cellular_component	microtubule cytoskeleton
B	0016042	biological_process	lipid catabolic process
B	0017145	biological_process	stem cell division
B	0019226	biological_process	transmission of nerve impulse
B	0021540	biological_process	corpus callosum morphogenesis
B	0021766	biological_process	hippocampus development
B	0021819	biological_process	layer formation in cerebral cortex
B	0021895	biological_process	cerebral cortex neuron differentiation
B	0021987	biological_process	cerebral cortex development
B	0030036	biological_process	actin cytoskeleton organization
B	0030154	biological_process	cell differentiation
B	0030424	cellular_component	axon
B	0030426	cellular_component	growth cone
B	0030900	biological_process	forebrain development
B	0031023	biological_process	microtubule organizing center organization
B	0031252	cellular_component	cell leading edge
B	0031514	cellular_component	motile cilium
B	0031965	cellular_component	nuclear membrane
B	0031982	cellular_component	vesicle
B	0032420	cellular_component	stereocilium
B	0034452	molecular_function	dynactin binding
B	0038026	biological_process	reelin-mediated signaling pathway
B	0040019	biological_process	positive regulation of embryonic development
B	0042249	biological_process	establishment of planar polarity of embryonic epithelium
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043274	molecular_function	phospholipase binding
B	0043622	biological_process	cortical microtubule organization
B	0044877	molecular_function	protein-containing complex binding
B	0045505	molecular_function	dynein intermediate chain binding
B	0045773	biological_process	positive regulation of axon extension
B	0045931	biological_process	positive regulation of mitotic cell cycle
B	0046469	biological_process	platelet activating factor metabolic process
B	0046982	molecular_function	protein heterodimerization activity
B	0047496	biological_process	vesicle transport along microtubule
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048854	biological_process	brain morphogenesis
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0050885	biological_process	neuromuscular process controlling balance
B	0051010	molecular_function	microtubule plus-end binding
B	0051012	biological_process	microtubule sliding
B	0051130	biological_process	positive regulation of cellular component organization
B	0051219	molecular_function	phosphoprotein binding
B	0051301	biological_process	cell division
B	0051656	biological_process	establishment of organelle localization
B	0051660	biological_process	establishment of centrosome localization
B	0060117	biological_process	auditory receptor cell development
B	0061003	biological_process	positive regulation of dendritic spine morphogenesis
B	0062234	biological_process	platelet activating factor catabolic process
B	0070062	cellular_component	extracellular exosome
B	0070507	biological_process	regulation of microtubule cytoskeleton organization
B	0070840	molecular_function	dynein complex binding
B	0090102	biological_process	cochlea development
B	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
B	0090724	cellular_component	central region of growth cone
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098978	cellular_component	glutamatergic synapse
B	0099175	biological_process	regulation of postsynapse organization
B	1904115	cellular_component	axon cytoplasm
C	0000132	biological_process	establishment of mitotic spindle orientation
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000235	cellular_component	astral microtubule
C	0000776	cellular_component	kinetochore
C	0001675	biological_process	acrosome assembly
C	0001764	biological_process	neuron migration
C	0005515	molecular_function	protein binding
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005871	cellular_component	kinesin complex
C	0005874	cellular_component	microtubule
C	0005875	cellular_component	microtubule associated complex
C	0005881	cellular_component	cytoplasmic microtubule
C	0005938	cellular_component	cell cortex
C	0006629	biological_process	lipid metabolic process
C	0007017	biological_process	microtubule-based process
C	0007097	biological_process	nuclear migration
C	0007268	biological_process	chemical synaptic transmission
C	0007281	biological_process	germ cell development
C	0007399	biological_process	nervous system development
C	0007405	biological_process	neuroblast proliferation
C	0007611	biological_process	learning or memory
C	0008017	molecular_function	microtubule binding
C	0008090	biological_process	retrograde axonal transport
C	0008201	molecular_function	heparin binding
C	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
C	0008344	biological_process	adult locomotory behavior
C	0010977	biological_process	negative regulation of neuron projection development
C	0015630	cellular_component	microtubule cytoskeleton
C	0016042	biological_process	lipid catabolic process
C	0017145	biological_process	stem cell division
C	0019226	biological_process	transmission of nerve impulse
C	0021540	biological_process	corpus callosum morphogenesis
C	0021766	biological_process	hippocampus development
C	0021819	biological_process	layer formation in cerebral cortex
C	0021895	biological_process	cerebral cortex neuron differentiation
C	0021987	biological_process	cerebral cortex development
C	0030036	biological_process	actin cytoskeleton organization
C	0030154	biological_process	cell differentiation
C	0030424	cellular_component	axon
C	0030426	cellular_component	growth cone
C	0030900	biological_process	forebrain development
C	0031023	biological_process	microtubule organizing center organization
C	0031252	cellular_component	cell leading edge
C	0031514	cellular_component	motile cilium
C	0031965	cellular_component	nuclear membrane
C	0031982	cellular_component	vesicle
C	0032420	cellular_component	stereocilium
C	0034452	molecular_function	dynactin binding
C	0038026	biological_process	reelin-mediated signaling pathway
C	0040019	biological_process	positive regulation of embryonic development
C	0042249	biological_process	establishment of planar polarity of embryonic epithelium
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043274	molecular_function	phospholipase binding
C	0043622	biological_process	cortical microtubule organization
C	0044877	molecular_function	protein-containing complex binding
C	0045505	molecular_function	dynein intermediate chain binding
C	0045773	biological_process	positive regulation of axon extension
C	0045931	biological_process	positive regulation of mitotic cell cycle
C	0046469	biological_process	platelet activating factor metabolic process
C	0046982	molecular_function	protein heterodimerization activity
C	0047496	biological_process	vesicle transport along microtubule
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048854	biological_process	brain morphogenesis
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0050885	biological_process	neuromuscular process controlling balance
C	0051010	molecular_function	microtubule plus-end binding
C	0051012	biological_process	microtubule sliding
C	0051130	biological_process	positive regulation of cellular component organization
C	0051219	molecular_function	phosphoprotein binding
C	0051301	biological_process	cell division
C	0051656	biological_process	establishment of organelle localization
C	0051660	biological_process	establishment of centrosome localization
C	0060117	biological_process	auditory receptor cell development
C	0061003	biological_process	positive regulation of dendritic spine morphogenesis
C	0062234	biological_process	platelet activating factor catabolic process
C	0070062	cellular_component	extracellular exosome
C	0070507	biological_process	regulation of microtubule cytoskeleton organization
C	0070840	molecular_function	dynein complex binding
C	0090102	biological_process	cochlea development
C	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
C	0090724	cellular_component	central region of growth cone
C	0098685	cellular_component	Schaffer collateral - CA1 synapse
C	0098978	cellular_component	glutamatergic synapse
C	0099175	biological_process	regulation of postsynapse organization
C	1904115	cellular_component	axon cytoplasm
D	0000132	biological_process	establishment of mitotic spindle orientation
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000235	cellular_component	astral microtubule
D	0000776	cellular_component	kinetochore
D	0001675	biological_process	acrosome assembly
D	0001764	biological_process	neuron migration
D	0005515	molecular_function	protein binding
D	0005635	cellular_component	nuclear envelope
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005871	cellular_component	kinesin complex
D	0005874	cellular_component	microtubule
D	0005875	cellular_component	microtubule associated complex
D	0005881	cellular_component	cytoplasmic microtubule
D	0005938	cellular_component	cell cortex
D	0006629	biological_process	lipid metabolic process
D	0007017	biological_process	microtubule-based process
D	0007097	biological_process	nuclear migration
D	0007268	biological_process	chemical synaptic transmission
D	0007281	biological_process	germ cell development
D	0007399	biological_process	nervous system development
D	0007405	biological_process	neuroblast proliferation
D	0007611	biological_process	learning or memory
D	0008017	molecular_function	microtubule binding
D	0008090	biological_process	retrograde axonal transport
D	0008201	molecular_function	heparin binding
D	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
D	0008344	biological_process	adult locomotory behavior
D	0010977	biological_process	negative regulation of neuron projection development
D	0015630	cellular_component	microtubule cytoskeleton
D	0016042	biological_process	lipid catabolic process
D	0017145	biological_process	stem cell division
D	0019226	biological_process	transmission of nerve impulse
D	0021540	biological_process	corpus callosum morphogenesis
D	0021766	biological_process	hippocampus development
D	0021819	biological_process	layer formation in cerebral cortex
D	0021895	biological_process	cerebral cortex neuron differentiation
D	0021987	biological_process	cerebral cortex development
D	0030036	biological_process	actin cytoskeleton organization
D	0030154	biological_process	cell differentiation
D	0030424	cellular_component	axon
D	0030426	cellular_component	growth cone
D	0030900	biological_process	forebrain development
D	0031023	biological_process	microtubule organizing center organization
D	0031252	cellular_component	cell leading edge
D	0031514	cellular_component	motile cilium
D	0031965	cellular_component	nuclear membrane
D	0031982	cellular_component	vesicle
D	0032420	cellular_component	stereocilium
D	0034452	molecular_function	dynactin binding
D	0038026	biological_process	reelin-mediated signaling pathway
D	0040019	biological_process	positive regulation of embryonic development
D	0042249	biological_process	establishment of planar polarity of embryonic epithelium
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0043274	molecular_function	phospholipase binding
D	0043622	biological_process	cortical microtubule organization
D	0044877	molecular_function	protein-containing complex binding
D	0045505	molecular_function	dynein intermediate chain binding
D	0045773	biological_process	positive regulation of axon extension
D	0045931	biological_process	positive regulation of mitotic cell cycle
D	0046469	biological_process	platelet activating factor metabolic process
D	0046982	molecular_function	protein heterodimerization activity
D	0047496	biological_process	vesicle transport along microtubule
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048854	biological_process	brain morphogenesis
D	0050804	biological_process	modulation of chemical synaptic transmission
D	0050885	biological_process	neuromuscular process controlling balance
D	0051010	molecular_function	microtubule plus-end binding
D	0051012	biological_process	microtubule sliding
D	0051130	biological_process	positive regulation of cellular component organization
D	0051219	molecular_function	phosphoprotein binding
D	0051301	biological_process	cell division
D	0051656	biological_process	establishment of organelle localization
D	0051660	biological_process	establishment of centrosome localization
D	0060117	biological_process	auditory receptor cell development
D	0061003	biological_process	positive regulation of dendritic spine morphogenesis
D	0062234	biological_process	platelet activating factor catabolic process
D	0070062	cellular_component	extracellular exosome
D	0070507	biological_process	regulation of microtubule cytoskeleton organization
D	0070840	molecular_function	dynein complex binding
D	0090102	biological_process	cochlea development
D	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
D	0090724	cellular_component	central region of growth cone
D	0098685	cellular_component	Schaffer collateral - CA1 synapse
D	0098978	cellular_component	glutamatergic synapse
D	0099175	biological_process	regulation of postsynapse organization
D	1904115	cellular_component	axon cytoplasm
E	0000132	biological_process	establishment of mitotic spindle orientation
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000235	cellular_component	astral microtubule
E	0000776	cellular_component	kinetochore
E	0001675	biological_process	acrosome assembly
E	0001764	biological_process	neuron migration
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005871	cellular_component	kinesin complex
E	0005874	cellular_component	microtubule
E	0005875	cellular_component	microtubule associated complex
E	0005881	cellular_component	cytoplasmic microtubule
E	0005938	cellular_component	cell cortex
E	0006629	biological_process	lipid metabolic process
E	0007017	biological_process	microtubule-based process
E	0007097	biological_process	nuclear migration
E	0007268	biological_process	chemical synaptic transmission
E	0007281	biological_process	germ cell development
E	0007399	biological_process	nervous system development
E	0007405	biological_process	neuroblast proliferation
E	0007611	biological_process	learning or memory
E	0008017	molecular_function	microtubule binding
E	0008090	biological_process	retrograde axonal transport
E	0008201	molecular_function	heparin binding
E	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
E	0008344	biological_process	adult locomotory behavior
E	0010977	biological_process	negative regulation of neuron projection development
E	0015630	cellular_component	microtubule cytoskeleton
E	0016042	biological_process	lipid catabolic process
E	0017145	biological_process	stem cell division
E	0019226	biological_process	transmission of nerve impulse
E	0021540	biological_process	corpus callosum morphogenesis
E	0021766	biological_process	hippocampus development
E	0021819	biological_process	layer formation in cerebral cortex
E	0021895	biological_process	cerebral cortex neuron differentiation
E	0021987	biological_process	cerebral cortex development
E	0030036	biological_process	actin cytoskeleton organization
E	0030154	biological_process	cell differentiation
E	0030424	cellular_component	axon
E	0030426	cellular_component	growth cone
E	0030900	biological_process	forebrain development
E	0031023	biological_process	microtubule organizing center organization
E	0031252	cellular_component	cell leading edge
E	0031514	cellular_component	motile cilium
E	0031965	cellular_component	nuclear membrane
E	0031982	cellular_component	vesicle
E	0032420	cellular_component	stereocilium
E	0034452	molecular_function	dynactin binding
E	0038026	biological_process	reelin-mediated signaling pathway
E	0040019	biological_process	positive regulation of embryonic development
E	0042249	biological_process	establishment of planar polarity of embryonic epithelium
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0043274	molecular_function	phospholipase binding
E	0043622	biological_process	cortical microtubule organization
E	0044877	molecular_function	protein-containing complex binding
E	0045505	molecular_function	dynein intermediate chain binding
E	0045773	biological_process	positive regulation of axon extension
E	0045931	biological_process	positive regulation of mitotic cell cycle
E	0046469	biological_process	platelet activating factor metabolic process
E	0046982	molecular_function	protein heterodimerization activity
E	0047496	biological_process	vesicle transport along microtubule
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048854	biological_process	brain morphogenesis
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0050885	biological_process	neuromuscular process controlling balance
E	0051010	molecular_function	microtubule plus-end binding
E	0051012	biological_process	microtubule sliding
E	0051130	biological_process	positive regulation of cellular component organization
E	0051219	molecular_function	phosphoprotein binding
E	0051301	biological_process	cell division
E	0051656	biological_process	establishment of organelle localization
E	0051660	biological_process	establishment of centrosome localization
E	0060117	biological_process	auditory receptor cell development
E	0061003	biological_process	positive regulation of dendritic spine morphogenesis
E	0062234	biological_process	platelet activating factor catabolic process
E	0070062	cellular_component	extracellular exosome
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0070840	molecular_function	dynein complex binding
E	0090102	biological_process	cochlea development
E	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
E	0090724	cellular_component	central region of growth cone
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098978	cellular_component	glutamatergic synapse
E	0099175	biological_process	regulation of postsynapse organization
E	1904115	cellular_component	axon cytoplasm
F	0000132	biological_process	establishment of mitotic spindle orientation
F	0000776	cellular_component	kinetochore
F	0000922	cellular_component	spindle pole
F	0005635	cellular_component	nuclear envelope
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005814	cellular_component	centriole
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005875	cellular_component	microtubule associated complex
F	0005938	cellular_component	cell cortex
F	0007017	biological_process	microtubule-based process
F	0007077	biological_process	mitotic nuclear membrane disassembly
F	0007097	biological_process	nuclear migration
F	0007528	biological_process	neuromuscular junction development
F	0008017	molecular_function	microtubule binding
F	0010008	cellular_component	endosome membrane
F	0010457	biological_process	centriole-centriole cohesion
F	0015630	cellular_component	microtubule cytoskeleton
F	0015631	molecular_function	tubulin binding
F	0019901	molecular_function	protein kinase binding
F	0021517	biological_process	ventral spinal cord development
F	0030286	cellular_component	dynein complex
F	0030424	cellular_component	axon
F	0030904	cellular_component	retromer complex
F	0031116	biological_process	positive regulation of microtubule polymerization
F	0031252	cellular_component	cell leading edge
F	0032935	molecular_function	sterol sensor activity
F	0032991	cellular_component	protein-containing complex
F	0034454	biological_process	microtubule anchoring at centrosome
F	0035371	cellular_component	microtubule plus-end
F	0036064	cellular_component	ciliary basal body
F	0042147	biological_process	retrograde transport, endosome to Golgi
F	0042632	biological_process	cholesterol homeostasis
F	0043005	cellular_component	neuron projection
F	0043025	cellular_component	neuronal cell body
F	0045171	cellular_component	intercellular bridge
F	0050905	biological_process	neuromuscular process
F	0051301	biological_process	cell division
F	0060236	biological_process	regulation of mitotic spindle organization
F	0061744	biological_process	motor behavior
F	0070050	biological_process	neuron cellular homeostasis
F	0090063	biological_process	positive regulation of microtubule nucleation
F	0090120	biological_process	lysosome to ER cholesterol transport
F	0120103	cellular_component	centriolar subdistal appendage
F	1904398	biological_process	positive regulation of neuromuscular junction development
F	1905515	biological_process	non-motile cilium assembly
F	1990535	biological_process	neuron projection maintenance
G	0000132	biological_process	establishment of mitotic spindle orientation
G	0000776	cellular_component	kinetochore
G	0000922	cellular_component	spindle pole
G	0005635	cellular_component	nuclear envelope
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005814	cellular_component	centriole
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005875	cellular_component	microtubule associated complex
G	0005938	cellular_component	cell cortex
G	0007017	biological_process	microtubule-based process
G	0007077	biological_process	mitotic nuclear membrane disassembly
G	0007097	biological_process	nuclear migration
G	0007528	biological_process	neuromuscular junction development
G	0008017	molecular_function	microtubule binding
G	0010008	cellular_component	endosome membrane
G	0010457	biological_process	centriole-centriole cohesion
G	0015630	cellular_component	microtubule cytoskeleton
G	0015631	molecular_function	tubulin binding
G	0019901	molecular_function	protein kinase binding
G	0021517	biological_process	ventral spinal cord development
G	0030286	cellular_component	dynein complex
G	0030424	cellular_component	axon
G	0030904	cellular_component	retromer complex
G	0031116	biological_process	positive regulation of microtubule polymerization
G	0031252	cellular_component	cell leading edge
G	0032935	molecular_function	sterol sensor activity
G	0032991	cellular_component	protein-containing complex
G	0034454	biological_process	microtubule anchoring at centrosome
G	0035371	cellular_component	microtubule plus-end
G	0036064	cellular_component	ciliary basal body
G	0042147	biological_process	retrograde transport, endosome to Golgi
G	0042632	biological_process	cholesterol homeostasis
G	0043005	cellular_component	neuron projection
G	0043025	cellular_component	neuronal cell body
G	0045171	cellular_component	intercellular bridge
G	0050905	biological_process	neuromuscular process
G	0051301	biological_process	cell division
G	0060236	biological_process	regulation of mitotic spindle organization
G	0061744	biological_process	motor behavior
G	0070050	biological_process	neuron cellular homeostasis
G	0090063	biological_process	positive regulation of microtubule nucleation
G	0090120	biological_process	lysosome to ER cholesterol transport
G	0120103	cellular_component	centriolar subdistal appendage
G	1904398	biological_process	positive regulation of neuromuscular junction development
G	1905515	biological_process	non-motile cilium assembly
G	1990535	biological_process	neuron projection maintenance
H	0001673	cellular_component	male germ cell nucleus
H	0003777	molecular_function	microtubule motor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0007018	biological_process	microtubule-based movement
H	0010970	biological_process	transport along microtubule
H	0030286	cellular_component	dynein complex
H	0031982	cellular_component	vesicle
H	0032388	biological_process	positive regulation of intracellular transport
H	0045503	molecular_function	dynein light chain binding
H	0045504	molecular_function	dynein heavy chain binding
H	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
I	0001673	cellular_component	male germ cell nucleus
I	0003777	molecular_function	microtubule motor activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0007018	biological_process	microtubule-based movement
I	0010970	biological_process	transport along microtubule
I	0030286	cellular_component	dynein complex
I	0031982	cellular_component	vesicle
I	0032388	biological_process	positive regulation of intracellular transport
I	0045503	molecular_function	dynein light chain binding
I	0045504	molecular_function	dynein heavy chain binding
I	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
J	0000166	molecular_function	nucleotide binding
J	0001673	cellular_component	male germ cell nucleus
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005868	cellular_component	cytoplasmic dynein complex
J	0005874	cellular_component	microtubule
J	0005881	cellular_component	cytoplasmic microtubule
J	0005938	cellular_component	cell cortex
J	0007018	biological_process	microtubule-based movement
J	0007052	biological_process	mitotic spindle organization
J	0007097	biological_process	nuclear migration
J	0008090	biological_process	retrograde axonal transport
J	0008569	molecular_function	minus-end-directed microtubule motor activity
J	0016020	cellular_component	membrane
J	0030175	cellular_component	filopodium
J	0030286	cellular_component	dynein complex
J	0031122	biological_process	cytoplasmic microtubule organization
J	0032388	biological_process	positive regulation of intracellular transport
J	0033962	biological_process	P-body assembly
J	0034063	biological_process	stress granule assembly
J	0035578	cellular_component	azurophil granule lumen
J	0042802	molecular_function	identical protein binding
J	0045505	molecular_function	dynein intermediate chain binding
J	0051293	biological_process	establishment of spindle localization
J	0051301	biological_process	cell division
J	0051959	molecular_function	dynein light intermediate chain binding
J	0060236	biological_process	regulation of mitotic spindle organization
J	0070062	cellular_component	extracellular exosome
J	0090235	biological_process	regulation of metaphase plate congression
J	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
J	0120162	biological_process	positive regulation of cold-induced thermogenesis
J	1904115	cellular_component	axon cytoplasm
J	1905832	biological_process	positive regulation of spindle assembly
K	0000132	biological_process	establishment of mitotic spindle orientation
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000235	cellular_component	astral microtubule
K	0000776	cellular_component	kinetochore
K	0001675	biological_process	acrosome assembly
K	0001764	biological_process	neuron migration
K	0005515	molecular_function	protein binding
K	0005635	cellular_component	nuclear envelope
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005871	cellular_component	kinesin complex
K	0005874	cellular_component	microtubule
K	0005875	cellular_component	microtubule associated complex
K	0005881	cellular_component	cytoplasmic microtubule
K	0005938	cellular_component	cell cortex
K	0006629	biological_process	lipid metabolic process
K	0007017	biological_process	microtubule-based process
K	0007097	biological_process	nuclear migration
K	0007268	biological_process	chemical synaptic transmission
K	0007281	biological_process	germ cell development
K	0007399	biological_process	nervous system development
K	0007405	biological_process	neuroblast proliferation
K	0007611	biological_process	learning or memory
K	0008017	molecular_function	microtubule binding
K	0008090	biological_process	retrograde axonal transport
K	0008201	molecular_function	heparin binding
K	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
K	0008344	biological_process	adult locomotory behavior
K	0010977	biological_process	negative regulation of neuron projection development
K	0015630	cellular_component	microtubule cytoskeleton
K	0016042	biological_process	lipid catabolic process
K	0017145	biological_process	stem cell division
K	0019226	biological_process	transmission of nerve impulse
K	0021540	biological_process	corpus callosum morphogenesis
K	0021766	biological_process	hippocampus development
K	0021819	biological_process	layer formation in cerebral cortex
K	0021895	biological_process	cerebral cortex neuron differentiation
K	0021987	biological_process	cerebral cortex development
K	0030036	biological_process	actin cytoskeleton organization
K	0030154	biological_process	cell differentiation
K	0030424	cellular_component	axon
K	0030426	cellular_component	growth cone
K	0030900	biological_process	forebrain development
K	0031023	biological_process	microtubule organizing center organization
K	0031252	cellular_component	cell leading edge
K	0031514	cellular_component	motile cilium
K	0031965	cellular_component	nuclear membrane
K	0031982	cellular_component	vesicle
K	0032420	cellular_component	stereocilium
K	0034452	molecular_function	dynactin binding
K	0038026	biological_process	reelin-mediated signaling pathway
K	0040019	biological_process	positive regulation of embryonic development
K	0042249	biological_process	establishment of planar polarity of embryonic epithelium
K	0042802	molecular_function	identical protein binding
K	0043005	cellular_component	neuron projection
K	0043025	cellular_component	neuronal cell body
K	0043274	molecular_function	phospholipase binding
K	0043622	biological_process	cortical microtubule organization
K	0044877	molecular_function	protein-containing complex binding
K	0045505	molecular_function	dynein intermediate chain binding
K	0045773	biological_process	positive regulation of axon extension
K	0045931	biological_process	positive regulation of mitotic cell cycle
K	0046469	biological_process	platelet activating factor metabolic process
K	0046982	molecular_function	protein heterodimerization activity
K	0047496	biological_process	vesicle transport along microtubule
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0048854	biological_process	brain morphogenesis
K	0050804	biological_process	modulation of chemical synaptic transmission
K	0050885	biological_process	neuromuscular process controlling balance
K	0051010	molecular_function	microtubule plus-end binding
K	0051012	biological_process	microtubule sliding
K	0051130	biological_process	positive regulation of cellular component organization
K	0051219	molecular_function	phosphoprotein binding
K	0051301	biological_process	cell division
K	0051656	biological_process	establishment of organelle localization
K	0051660	biological_process	establishment of centrosome localization
K	0060117	biological_process	auditory receptor cell development
K	0061003	biological_process	positive regulation of dendritic spine morphogenesis
K	0062234	biological_process	platelet activating factor catabolic process
K	0070062	cellular_component	extracellular exosome
K	0070507	biological_process	regulation of microtubule cytoskeleton organization
K	0070840	molecular_function	dynein complex binding
K	0090102	biological_process	cochlea development
K	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
K	0090724	cellular_component	central region of growth cone
K	0098685	cellular_component	Schaffer collateral - CA1 synapse
K	0098978	cellular_component	glutamatergic synapse
K	0099175	biological_process	regulation of postsynapse organization
K	1904115	cellular_component	axon cytoplasm
L	0000132	biological_process	establishment of mitotic spindle orientation
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000235	cellular_component	astral microtubule
L	0000776	cellular_component	kinetochore
L	0001675	biological_process	acrosome assembly
L	0001764	biological_process	neuron migration
L	0005515	molecular_function	protein binding
L	0005635	cellular_component	nuclear envelope
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005819	cellular_component	spindle
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005871	cellular_component	kinesin complex
L	0005874	cellular_component	microtubule
L	0005875	cellular_component	microtubule associated complex
L	0005881	cellular_component	cytoplasmic microtubule
L	0005938	cellular_component	cell cortex
L	0006629	biological_process	lipid metabolic process
L	0007017	biological_process	microtubule-based process
L	0007097	biological_process	nuclear migration
L	0007268	biological_process	chemical synaptic transmission
L	0007281	biological_process	germ cell development
L	0007399	biological_process	nervous system development
L	0007405	biological_process	neuroblast proliferation
L	0007611	biological_process	learning or memory
L	0008017	molecular_function	microtubule binding
L	0008090	biological_process	retrograde axonal transport
L	0008201	molecular_function	heparin binding
L	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
L	0008344	biological_process	adult locomotory behavior
L	0010977	biological_process	negative regulation of neuron projection development
L	0015630	cellular_component	microtubule cytoskeleton
L	0016042	biological_process	lipid catabolic process
L	0017145	biological_process	stem cell division
L	0019226	biological_process	transmission of nerve impulse
L	0021540	biological_process	corpus callosum morphogenesis
L	0021766	biological_process	hippocampus development
L	0021819	biological_process	layer formation in cerebral cortex
L	0021895	biological_process	cerebral cortex neuron differentiation
L	0021987	biological_process	cerebral cortex development
L	0030036	biological_process	actin cytoskeleton organization
L	0030154	biological_process	cell differentiation
L	0030424	cellular_component	axon
L	0030426	cellular_component	growth cone
L	0030900	biological_process	forebrain development
L	0031023	biological_process	microtubule organizing center organization
L	0031252	cellular_component	cell leading edge
L	0031514	cellular_component	motile cilium
L	0031965	cellular_component	nuclear membrane
L	0031982	cellular_component	vesicle
L	0032420	cellular_component	stereocilium
L	0034452	molecular_function	dynactin binding
L	0038026	biological_process	reelin-mediated signaling pathway
L	0040019	biological_process	positive regulation of embryonic development
L	0042249	biological_process	establishment of planar polarity of embryonic epithelium
L	0042802	molecular_function	identical protein binding
L	0043005	cellular_component	neuron projection
L	0043025	cellular_component	neuronal cell body
L	0043274	molecular_function	phospholipase binding
L	0043622	biological_process	cortical microtubule organization
L	0044877	molecular_function	protein-containing complex binding
L	0045505	molecular_function	dynein intermediate chain binding
L	0045773	biological_process	positive regulation of axon extension
L	0045931	biological_process	positive regulation of mitotic cell cycle
L	0046469	biological_process	platelet activating factor metabolic process
L	0046982	molecular_function	protein heterodimerization activity
L	0047496	biological_process	vesicle transport along microtubule
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0048854	biological_process	brain morphogenesis
L	0050804	biological_process	modulation of chemical synaptic transmission
L	0050885	biological_process	neuromuscular process controlling balance
L	0051010	molecular_function	microtubule plus-end binding
L	0051012	biological_process	microtubule sliding
L	0051130	biological_process	positive regulation of cellular component organization
L	0051219	molecular_function	phosphoprotein binding
L	0051301	biological_process	cell division
L	0051656	biological_process	establishment of organelle localization
L	0051660	biological_process	establishment of centrosome localization
L	0060117	biological_process	auditory receptor cell development
L	0061003	biological_process	positive regulation of dendritic spine morphogenesis
L	0062234	biological_process	platelet activating factor catabolic process
L	0070062	cellular_component	extracellular exosome
L	0070507	biological_process	regulation of microtubule cytoskeleton organization
L	0070840	molecular_function	dynein complex binding
L	0090102	biological_process	cochlea development
L	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
L	0090724	cellular_component	central region of growth cone
L	0098685	cellular_component	Schaffer collateral - CA1 synapse
L	0098978	cellular_component	glutamatergic synapse
L	0099175	biological_process	regulation of postsynapse organization
L	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
A	ILE2216-SER2226

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF

Chain	Residue	Details
B	LEU165-PHE179
B	ILE207-VAL221
B	LEU311-VAL325
B	VAL395-CYS409

---

site_id	PS00845
Number of Residues	32
Details	CAP_GLY_1 CAP-Gly domain signature. Gatlfatgk..WvGVilDeak....GKNdGTvqGrkYF

Chain	Residue	Details
F	GLY48-PHE79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	498
Details	Region: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	538
Details	Region: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	458
Details	Region: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	432
Details	Region: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	126
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	56
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	164
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	156
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	156
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	156
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	164
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	128
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	168
Details	Region: {"description":"Interaction with DCX","evidences":[{"source":"PubMed","id":"11001923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	88
Details	Region: {"description":"Interaction with NDEL1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	64
Details	Domain: {"description":"LisH","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	130
Details	Region: {"description":"Interaction with NDE1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	74
Details	Region: {"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---