8PM3
Crystal structure of MAP2K6 with a covalent compound GCL94
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Dual specificity mitogen-activated protein kinase kinase 6 | polymer | 290 | 32749.9 | 4 | UniProt (P52564) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase kinase 6,MAPKK 6,MAPK/ERK kinase 6,MEK 6,Stress-activated protein kinase kinase 3,SAPK kinase 3,SAPKK-3,SAPKK3 |
2 | A, B, C, D | ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide | non-polymer | 241.3 | 4 | Chemie (ZLE) | |||
3 | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 47 - 334 (UniProt: P52564)
PDB | External Database | Details |
---|---|---|
Ser 45 | - | expression tag |
Met 46 | - | expression tag |
Asp 207 | Ser 207 | engineered mutation |
Asp 211 | Thr 211 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 130999.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 965.2 | |
All* | Total formula weight | 131964.7 |