8PM3
Crystal structure of MAP2K6 with a covalent compound GCL94
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dual specificity mitogen-activated protein kinase kinase 6 | polymer | 290 | 32749.9 | 4 | UniProt (P52564) Pfam (PF00069) | Homo sapiens (human) | MAP kinase kinase 6,MAPKK 6,MAPK/ERK kinase 6,MEK 6,Stress-activated protein kinase kinase 3,SAPK kinase 3,SAPKK-3,SAPKK3 |
| 2 | E, F, G, H (A, B, C, D) | ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide | non-polymer | 241.3 | 4 | Chemie (ZLE) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 47 - 334 (UniProt: P52564)
| PDB | External Database | Details |
|---|---|---|
| Ser 45 | - | expression tag |
| Met 46 | - | expression tag |
| Asp 207 | Ser 207 | engineered mutation |
| Asp 211 | Thr 211 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130999.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 965.2 | |
| All* | Total formula weight | 131964.7 |
