8PM3

Crystal structure of MAP2K6 with a covalent compound GCL94

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGAYGVVEkMrhvpsgqi..........MAVK

Chain	Residue	Details
A	LEU59-LYS82

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNVLI

Chain	Residue	Details
A	VAL175-ILE187

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP179
B	ASP179
C	ASP179
D	ASP179

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU59
A	LYS82
B	LEU59
B	LYS82
C	LEU59
C	LYS82
D	LEU59
D	LYS82

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAP3K; alternate => ECO:0000269|PubMed:16728640

Chain	Residue	Details
A	ASP207
B	ASP207
C	ASP207
D	ASP207

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAP3K; alternate => ECO:0000269|PubMed:16728640

Chain	Residue	Details
A	ASP211
B	ASP211
C	ASP211
D	ASP211

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