8OW0
Cryo-EM structure of CBF1-CCAN bound topologically to a centromeric CENP-A nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | C0N3 DNA | polymer | 153 | 47239.3 | 1 | Saccharomyces cerevisiae | ||
| 2 | B (E) | C0N3 DNA | polymer | 153 | 47194.2 | 1 | Saccharomyces cerevisiae | ||
| 3 | C, F (b, f) | Histone H4 | polymer | 103 | 11395.4 | 2 | UniProt (P02309) Pfam (PF15511) | Saccharomyces cerevisiae (baker's yeast) | |
| 4 | D, H (d, h) | Histone H2B.1 | polymer | 131 | 14280.4 | 2 | UniProt (P02293) Pfam (PF00125) | Saccharomyces cerevisiae (baker's yeast) | Suppressor of Ty protein 12 |
| 5 | E, J (e, a) | Histone H3-like centromeric protein CSE4 | polymer | 229 | 26885.4 | 2 | UniProt (P36012) Pfam (PF00125) | Saccharomyces cerevisiae (baker's yeast) | CENP-A homolog,CENPA homolog,Chromosome segregation protein 4 |
| 6 | G, I (g, c) | Histone H2A.1 | polymer | 132 | 14013.2 | 2 | UniProt (P04911) Pfam (PF16211) Pfam (PF00125) | Saccharomyces cerevisiae (baker's yeast) | |
| 7 | K, L (A, B) | Centromere-binding protein 1 | polymer | 351 | 39444.7 | 2 | UniProt (P17106) Pfam (PF00010) | Saccharomyces cerevisiae (baker's yeast) | CBP-1,Centromere promoter factor 1,Centromere-binding factor 1 |
| 8 | M (H) | Inner kinetochore subunit MCM16 | polymer | 181 | 21166.1 | 1 | UniProt (Q12262) Pfam (PF20993) | Saccharomyces cerevisiae (baker's yeast) | CENP-H homolog,Constitutive centromere-associated network protein MCM16,Minichromosome maintenance protein 16 |
| 9 | N (I) | Inner kinetochore subunit CTF3 | polymer | 733 | 84345.6 | 1 | UniProt (Q12748) | Saccharomyces cerevisiae (baker's yeast) | CENP-I homolog,Chromosome loss protein 3,Chromosome transmission fidelity protein 3,Constitutive centromere-associated network protein CTF3 |
| 10 | O (K) | Inner kinetochore subunit MCM22 | polymer | 239 | 27602.5 | 1 | UniProt (P47167) | Saccharomyces cerevisiae (baker's yeast) | CENP-K homolog,Constitutive centromere-associated network protein MCM22,Minichromosome maintenance protein 22 |
| 11 | P (L) | Inner kinetochore subunit IML3 | polymer | 245 | 28093.2 | 1 | UniProt (P38265) | Saccharomyces cerevisiae (baker's yeast) | CENP-L homolog,Constitutive centromere-associated network protein IML3,Increased minichromosome loss protein 3,Minichromosome maintenance protein 19 |
| 12 | Q (N) | Inner kinetochore subunit CHL4 | polymer | 458 | 52743.7 | 1 | UniProt (P38907) Pfam (PF05238) | Saccharomyces cerevisiae (baker's yeast) | CENP-N homolog,Chromosome loss protein 4,Chromosome transmission fidelity protein 17,Constitutive centromere-associated network protein CHL4,Minichromosome maintenance protein 17 |
| 13 | R (O) | Inner kinetochore subunit MCM21 | polymer | 368 | 43028.9 | 1 | UniProt (Q06675) Pfam (PF09496) | Saccharomyces cerevisiae (baker's yeast) | CENP-O homolog,Chromosome transmission fidelity protein 5,Constitutive centromere-associated network protein MCM21,Minichromosome maintenance protein 21 |
| 14 | S (P) | Inner kinetochore subunit CTF19 | polymer | 369 | 42841.1 | 1 | UniProt (Q02732) | Saccharomyces cerevisiae (baker's yeast) | CENP-P homolog,Chromosome transmission fidelity protein 19,Constitutive centromere-associated network protein CTF19,Minichromosome maintenance protein 18 |
| 15 | T (Q) | Inner kinetochore subunit OKP1 | polymer | 406 | 47427.2 | 1 | UniProt (P53298) | Saccharomyces cerevisiae (baker's yeast) | CENP-Q homolog,Constitutive centromere-associated network protein OKP1,Outer kinetochore protein 1 |
| 16 | U (T) | Inner kinetochore subunit CNN1 | polymer | 361 | 41359.8 | 1 | UniProt (P43618) | Saccharomyces cerevisiae (baker's yeast) | CENP-T homolog,Co-purified with NNF1 protein 1,Constitutive centromere-associated network protein CNN1 |
| 17 | V (U) | Inner kinetochore subunit AME1 | polymer | 324 | 37506.7 | 1 | UniProt (P38313) Pfam (PF20994) | Saccharomyces cerevisiae (baker's yeast) | Associated with microtubules and essential protein 1,CENP-U homolog,Constitutive centromere-associated network protein AME1 |
| 18 | W (W) | Inner kinetochore subunit WIP1 | polymer | 89 | 10255.5 | 1 | UniProt (Q2V2P8) | Saccharomyces cerevisiae (baker's yeast) | CENP-W homolog,Constitutive centromere-associated network protein WIP1,W-like protein 1 |
| 19 | X (Y) | Inner kinetochore subunit NKP1 | polymer | 238 | 27006.5 | 1 | UniProt (Q12493) | Saccharomyces cerevisiae (baker's yeast) | Constitutive centromere-associated network protein NKP1,Non-essential kinetochore protein 1 |
| 20 | Y (Z) | Inner kinetochore subunit NKP2 | polymer | 153 | 17877.0 | 1 | UniProt (Q06162) Pfam (PF09447) | Saccharomyces cerevisiae (baker's yeast) | Constitutive centromere-associated network protein NKP2,Non-essential kinetochore protein 2 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 25 |
| Total formula weight | 787725.5 | |
| All* | Total formula weight | 787725.5 |
