8OIX
CryoEM structure of 20S Trichomonas vaginalis proteasome in complex with proteasome inhibitor Salinosporamid A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | Family T1, proteasome alpha subunit, threonine peptidase | polymer | 241 | 26511.2 | 2 | UniProt (A2F568) Pfam (PF10584) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 2 | B, P (B, P) | Family T1, proteasome alpha subunit, threonine peptidase | polymer | 232 | 25445.0 | 2 | UniProt (A2FJV7) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 3 | C, Q (C, Q) | Proteasome subunit alpha type | polymer | 251 | 27989.7 | 2 | UniProt (A2FT79) Pfam (PF10584) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 4 | D, R (D, R) | Proteasome subunit alpha type | polymer | 235 | 26306.9 | 2 | UniProt (A2DTN3) Pfam (PF10584) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 5 | E, S (E, S) | Proteasome subunit alpha type | polymer | 251 | 27331.0 | 2 | UniProt (A2FCM7) Pfam (PF10584) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 6 | F, T (F, T) | Family T1, proteasome alpha subunit, threonine peptidase | polymer | 233 | 25682.3 | 2 | UniProt (A2E1I9) Pfam (PF10584) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 7 | G, U (G, U) | Family T1, proteasome alpha subunit, threonine peptidase | polymer | 240 | 27067.4 | 2 | UniProt (A2D8G5) Pfam (PF10584) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 8 | H, V (H, V) | Proteasome subunit beta | polymer | 204 | 21930.8 | 2 | UniProt (A2E7Z2) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 9 | I, W (I, W) | proteasome endopeptidase complex | polymer | 244 | 26869.4 | 2 | UniProt (A2F2T6) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 10 | J, X (J, X) | Proteasome subunit beta | polymer | 206 | 23028.6 | 2 | UniProt (A2F3H9) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 11 | K, Y (K, Y) | Proteasome subunit beta | polymer | 191 | 21421.6 | 2 | UniProt (A2F8W4) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 12 | L, Z (L, Z) | Proteasome subunit beta | polymer | 203 | 22572.6 | 2 | UniProt (A2DD57) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 13 | AA, M (M, a) | Proteasome subunit beta | polymer | 224 | 25001.0 | 2 | UniProt (A2F716) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 14 | BA, N (N, b) | Family T1, proteasome beta subunit, threonine peptidase | polymer | 244 | 26486.6 | 2 | UniProt (A2F3X4) Pfam (PF00227) | Trichomonas vaginalis G3 | |
| 15 | CA, DA, EA, FA (H, I, V, W) | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | non-polymer | 279.3 | 4 | Chemie (SA1) |
Sequence modifications
N, b: 1 - 214 (UniProt: A2F3X4)
| PDB | External Database | Details |
|---|---|---|
| Ser 215 | - | expression tag |
| Ala 216 | - | expression tag |
| Trp 217 | - | expression tag |
| Ser 218 | - | expression tag |
| His 219 | - | expression tag |
| Pro 220 | - | expression tag |
| Gln 221 | - | expression tag |
| Phe 222 | - | expression tag |
| Glu 223 | - | expression tag |
| Lys 224 | - | expression tag |
| Gly 225 | - | expression tag |
| Gly 226 | - | expression tag |
| Gly 227 | - | expression tag |
| Ser 228 | - | expression tag |
| Gly 229 | - | expression tag |
| Gly 230 | - | expression tag |
| Gly 231 | - | expression tag |
| Ser 232 | - | expression tag |
| Gly 233 | - | expression tag |
| Gly 234 | - | expression tag |
| Ser 235 | - | expression tag |
| Ala 236 | - | expression tag |
| Trp 237 | - | expression tag |
| Ser 238 | - | expression tag |
| His 239 | - | expression tag |
| Pro 240 | - | expression tag |
| Gln 241 | - | expression tag |
| Phe 242 | - | expression tag |
| Glu 243 | - | expression tag |
| Lys 244 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 707288.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1117.3 | |
| All* | Total formula weight | 708405.7 |
