8JEL

Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (C, A, F, I)	antibody heavy chain	polymer	222	23784.6	4		Homo sapiens (human)
2	B, E, H, K (D, B, G, K)	antibody light chain	polymer	214	23302.9	4		Homo sapiens (human)
3	C, F, I, L (J, E, H, L)	T-cell immunoreceptor with Ig and ITIM domains	polymer	115	12759.2	4	UniProt (Q495A1) Pfam (PF07686)	Homo sapiens (human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
4	M, N, O, P, Q... (C, D, J, A, B...)	water	water		18.0	818	Chemie (HOH)

Sequence modifications

J, E, H, L: 22 - 128 (UniProt: Q495A1)

PDB	External Database	Details
Leu 129	-	expression tag
Glu 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	239386.8
All*	Total formula weight	239386.8

*Water molecules are not included.