8JEL

Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005102	molecular_function	signaling receptor binding
E	0050868	biological_process	negative regulation of T cell activation
H	0005102	molecular_function	signaling receptor binding
H	0050868	biological_process	negative regulation of T cell activation
J	0005102	molecular_function	signaling receptor binding
J	0050868	biological_process	negative regulation of T cell activation
L	0005102	molecular_function	signaling receptor binding
L	0050868	biological_process	negative regulation of T cell activation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
C	TYR200-HIS206
D	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	102
Details	Domain: {"description":"Ig-like V-type"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Region: {"description":"Homodimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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