8J6K
Crystal structure of pro-interleukin-18 and caspase-4 complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Caspase-4 subunit p20 | polymer | 169 | 19330.0 | 1 | UniProt (P49662) Pfam (PF00656) | Homo sapiens (human) | |
| 2 | B (a) | Caspase-4 subunit p10 | polymer | 88 | 10424.0 | 1 | UniProt (P49662) Pfam (PF00656) | Homo sapiens (human) | CASP-4,ICE and Ced-3 homolog 2,ICH-2,ICE(rel)-II,Mih1,Protease TX |
| 3 | C (B) | Interleukin-18 | polymer | 194 | 22437.3 | 1 | UniProt (Q14116) Pfam (PF00340) | Homo sapiens (human) | IL-18,Iboctadekin,Interferon gamma-inducing factor,IFN-gamma-inducing factor,Interleukin-1 gamma,IL-1 gamma |
| 4 | D (C) | Arginine ADP-riboxanase OspC3 | polymer | 161 | 18366.2 | 1 | UniProt (A0A0H2US87) Pfam (PF06128) | Shigella flexneri |
Sequence modifications
A: 102 - 270 (UniProt: P49662)
B: 1 - 193 (UniProt: Q14116)
C: 332 - 484 (UniProt: A0A0H2US87)
| PDB | External Database | Details |
|---|---|---|
| Ala 258 | Cys 258 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 324 | - | expression tag |
| Pro 325 | - | expression tag |
| Leu 326 | - | expression tag |
| Gly 327 | - | expression tag |
| Ser 328 | - | expression tag |
| Gly 329 | - | expression tag |
| Arg 330 | - | expression tag |
| Pro 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70557.5 | |
| All* | Total formula weight | 70557.5 |
