8J6K

Crystal structure of pro-interleukin-18 and caspase-4 complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Caspase-4 subunit p20	polymer	169	19330.0	1	UniProt (P49662) Pfam (PF00656) In PDB	Homo sapiens (human)
2	a	Caspase-4 subunit p10	polymer	88	10424.0	1	UniProt (P49662) Pfam (PF00656) In PDB	Homo sapiens (human)	CASP-4,ICE and Ced-3 homolog 2,ICH-2,ICE(rel)-II,Mih1,Protease TX
3	B	Interleukin-18	polymer	194	22437.3	1	UniProt (Q14116) Pfam (PF00340) In PDB	Homo sapiens (human)	IL-18,Iboctadekin,Interferon gamma-inducing factor,IFN-gamma-inducing factor,Interleukin-1 gamma,IL-1 gamma
4	C	Arginine ADP-riboxanase OspC3	polymer	161	18366.2	1	UniProt (A0A0H2US87) Pfam (PF06128) In PDB	Shigella flexneri

Sequence modifications

A: 102 - 270 (UniProt: P49662)

PDB	External Database	Details
Ala 258	Cys 258	engineered mutation

B: 1 - 193 (UniProt: Q14116)

PDB	External Database	Details
Ser 0	-	expression tag

C: 332 - 484 (UniProt: A0A0H2US87)

PDB	External Database	Details
Gly 324	-	expression tag
Pro 325	-	expression tag
Leu 326	-	expression tag
Gly 327	-	expression tag
Ser 328	-	expression tag
Gly 329	-	expression tag
Arg 330	-	expression tag
Pro 331	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	70557.5
All*	Total formula weight	70557.5

*Water molecules are not included.