8J6K

Crystal structure of pro-interleukin-18 and caspase-4 complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004197	molecular_function	cysteine-type endopeptidase activity
a	0006508	biological_process	proteolysis
a	0008234	molecular_function	cysteine-type peptidase activity
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0001525	biological_process	angiogenesis
B	0002826	biological_process	negative regulation of T-helper 1 type immune response
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007267	biological_process	cell-cell signaling
B	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0030155	biological_process	regulation of cell adhesion
B	0030431	biological_process	sleep
B	0032722	biological_process	positive regulation of chemokine production
B	0032725	biological_process	positive regulation of granulocyte macrophage colony-stimulating factor production
B	0032729	biological_process	positive regulation of type II interferon production
B	0032736	biological_process	positive regulation of interleukin-13 production
B	0032740	biological_process	positive regulation of interleukin-17 production
B	0032819	biological_process	positive regulation of natural killer cell proliferation
B	0034105	biological_process	positive regulation of tissue remodeling
B	0035655	biological_process	interleukin-18-mediated signaling pathway
B	0042088	biological_process	T-helper 1 type immune response
B	0042092	biological_process	type 2 immune response
B	0042104	biological_process	positive regulation of activated T cell proliferation
B	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
B	0042632	biological_process	cholesterol homeostasis
B	0045063	biological_process	T-helper 1 cell differentiation
B	0045515	molecular_function	interleukin-18 receptor binding
B	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0048018	molecular_function	receptor ligand activity
B	0048661	biological_process	positive regulation of smooth muscle cell proliferation
B	0050729	biological_process	positive regulation of inflammatory response
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051142	biological_process	positive regulation of NK T cell proliferation
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0061436	biological_process	establishment of skin barrier
B	0070328	biological_process	triglyceride homeostasis
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0150078	biological_process	positive regulation of neuroinflammatory response
B	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
B	2000556	biological_process	positive regulation of T-helper 1 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HkssdStfLvLMSHG

Chain	Residue	Details
A	HIS197-GLY211

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P29466","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"22246630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23661706","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25119034","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993712","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7743998","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"source":"PubMed","id":"34671164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36624349","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage; by CASP1, CASP4 and CASP5","evidences":[{"source":"PubMed","id":"25261253","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993712","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9334240","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	29
Details	Repeat: {"description":"ANK 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	31
Details	Repeat: {"description":"ANK 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Repeat: {"description":"ANK 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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