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8J6K

Crystal structure of pro-interleukin-18 and caspase-4 complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
a0004197molecular_functioncysteine-type endopeptidase activity
a0006508biological_processproteolysis
a0008234molecular_functioncysteine-type peptidase activity
A0004197molecular_functioncysteine-type endopeptidase activity
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0001525biological_processangiogenesis
B0001819biological_processpositive regulation of cytokine production
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007267biological_processcell-cell signaling
B0008283biological_processcell population proliferation
B0010628biological_processpositive regulation of gene expression
B0010744biological_processpositive regulation of macrophage derived foam cell differentiation
B0030101biological_processnatural killer cell activation
B0030155biological_processregulation of cell adhesion
B0030431biological_processsleep
B0032722biological_processpositive regulation of chemokine production
B0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
B0032729biological_processpositive regulation of type II interferon production
B0032736biological_processpositive regulation of interleukin-13 production
B0032740biological_processpositive regulation of interleukin-17 production
B0032819biological_processpositive regulation of natural killer cell proliferation
B0034105biological_processpositive regulation of tissue remodeling
B0035655biological_processinterleukin-18-mediated signaling pathway
B0042088biological_processT-helper 1 type immune response
B0042092biological_processtype 2 immune response
B0042104biological_processpositive regulation of activated T cell proliferation
B0042119biological_processneutrophil activation
B0042267biological_processnatural killer cell mediated cytotoxicity
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0042632biological_processcholesterol homeostasis
B0045515molecular_functioninterleukin-18 receptor binding
B0045630biological_processpositive regulation of T-helper 2 cell differentiation
B0045662biological_processnegative regulation of myoblast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048018molecular_functionreceptor ligand activity
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050729biological_processpositive regulation of inflammatory response
B0050830biological_processdefense response to Gram-positive bacterium
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051142biological_processpositive regulation of NK T cell proliferation
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0061436biological_processestablishment of skin barrier
B0070328biological_processtriglyceride homeostasis
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0150078biological_processpositive regulation of neuroinflammatory response
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B2000556biological_processpositive regulation of T-helper 1 cell cytokine production
Functional Information from PROSITE/UniProt
site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HkssdStfLvLMSHG
ChainResidueDetails
AHIS197-GLY211

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by CASP1, CASP4 and CASP5 => ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240
ChainResidueDetails
BASP36

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by CASP3 => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240
ChainResidueDetails
BASP71

223166

PDB entries from 2024-07-31

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