8J6F
Cryo-EM structure of the Tocilizumab Fab/IL-6R complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Heavy chain of Tocilizumab Fab | polymer | 226 | 24125.1 | 1 | Homo sapiens (human) | ||
| 2 | B (L) | Light chain of Tocilizumab Fab | polymer | 214 | 23527.1 | 1 | Homo sapiens (human) | ||
| 3 | C (I) | Interleukin-6 receptor subunit alpha | polymer | 365 | 40283.4 | 1 | UniProt (P08887) Pfam (PF00047) Pfam (PF09240) | Homo sapiens (human) | IL-6 receptor subunit alpha,IL-6R subunit alpha,IL-6R-alpha,IL-6RA,IL-6R 1,Membrane glycoprotein 80,gp80 |
| 4 | D (B) | IL6R-D2 peptide | polymer | 10 | 1148.4 | 1 | UniProt (P08887) | Homo sapiens (human) | IL-6 receptor subunit alpha,IL-6R subunit alpha,IL-6R-alpha,IL-6RA,IL-6R 1,Membrane glycoprotein 80,gp80 |
| 5 | E (I) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89084.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 89305.2 |
