8J6F
Cryo-EM structure of the Tocilizumab Fab/IL-6R complex
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR200-HIS206 |
| site_id | PS01354 |
| Number of Residues | 42 |
| Details | HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LqPDPPanItvtavarnprwLsvtWqdPhSWnssf..YrLrFeL |
| Chain | Residue | Details |
| I | LEU214-LEU255 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 345 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| I | LEU20-LEU365 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Not glycosylated => ECO:0000269|PubMed:10066782 |
| Chain | Residue | Details |
| I | ASN245 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by ADAM10 and ADAM17 => ECO:0000269|PubMed:28060820 |
| Chain | Residue | Details |
| I | PRO355 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10066782, ECO:0000269|PubMed:28060820 |
| Chain | Residue | Details |
| I | ASN55 | |
| I | ASN93 | |
| I | ASN221 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28060820 |
| Chain | Residue | Details |
| I | ASN245 | |
| I | ASN350 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:28060820 |
| Chain | Residue | Details |
| I | THR352 |
