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8ITF

Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer36242010.71Homo sapiens (human)
2B
(B)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37741055.91UniProt (P62873)
Pfam (PF00400)
Homo sapiens (human)
3C
(C)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer586375.31UniProt (P59768)
Pfam (PF00631)
Homo sapiens (human)G gamma-I
4D
(R)
Trace amine-associated receptor 9polymer34838928.21UniProt (Q5QD04)
Pfam (PF00001)
Mus musculus (house mouse)TaR-9,Trace amine receptor 9,mTaar9
5E
(S)
scFv16polymer28530363.01synthetic construct
6F
(N)
Nanobody-35polymer12813885.41synthetic construct
7G
(R)
~{N},~{N}-dimethylcyclohexanaminenon-polymer127.21Chemie (8IA)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -10-initiating methionine
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight172618.6
Non-Polymers*Number of molecules1
Total formula weight127.2
All*Total formula weight172745.8
*Water molecules are not included.

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PDB entries from 2024-10-30

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