8ITF
Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| B | 0007213 | biological_process | G protein-coupled acetylcholine receptor signaling pathway |
| B | 0007265 | biological_process | Ras protein signal transduction |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0016020 | cellular_component | membrane |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0050909 | biological_process | sensory perception of taste |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| B | 0071870 | biological_process | cellular response to catecholamine stimulus |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| B | 1903561 | cellular_component | extracellular vesicle |
| C | 0005834 | cellular_component | heterotrimeric G-protein complex |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0031681 | molecular_function | G-protein beta-subunit binding |
| R | 0001594 | molecular_function | trace-amine receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0008227 | molecular_function | G protein-coupled amine receptor activity |
| R | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASLfHLCCISIDRYIaV |
| Chain | Residue | Details |
| R | ALA118-VAL134 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 | |
| B | VAL327-GLY341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 83 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | MET1-ALA33 | |
| R | VAL91-CYS105 | |
| R | GLY171-GLN196 | |
| R | ASP281-TYR293 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | ILE34-LEU58 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 98 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | HIS59-ASN68 | |
| R | ASP129-VAL148 | |
| R | ARG219-ALA256 | |
| R | TYR315-GLY348 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | PHE69-THR90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | LYS106-ILE128 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | SER149-THR170 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | ASN197-GLY218 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | ALA257-ILE280 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM |
| Chain | Residue | Details |
| R | GLU294-PHE314 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IWE |
| Chain | Residue | Details |
| R | ASP112 | |
| R | THR113 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN19 |
