8IOW

Cryo-EM structure of the sarilumab Fab/IL-6R complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (I, D2)	Interleukin-6 receptor subunit alpha	polymer	365	40283.4	2	UniProt (P08887) Pfam (PF00047) Pfam (PF09240)	Homo sapiens (human)	IL-6 receptor subunit alpha,IL-6R subunit alpha,IL-6R-alpha,IL-6RA,IL-6R 1,Membrane glycoprotein 80,gp80,IL-6R-D2
2	C (L)	Light chain of Sarilumab Fab	polymer	214	23253.7	1		Homo sapiens (human)
3	D (H)	Heavy chain of Sarilumab Fab	polymer	223	23825.7	1		Homo sapiens (human)
4	E, F (I)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127646.3
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	128088.7

*Water molecules are not included.