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8IOW

Cryo-EM structure of the sarilumab Fab/IL-6R complex

This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR192-HIS198
HTYR197-HIS203

site_idPS01354
Number of Residues42
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LqPDPPanItvtavarnprwLsvtWqdPhSWnssf..YrLrFeL
ChainResidueDetails
ILEU214-LEU255

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues690
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ILEU20-LEU365
D2LEU20-LEU365

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Not glycosylated => ECO:0000269|PubMed:10066782
ChainResidueDetails
IASN245
D2ASN245

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by ADAM10 and ADAM17 => ECO:0000269|PubMed:28060820
ChainResidueDetails
IPRO355
D2PRO355

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10066782, ECO:0000269|PubMed:28060820
ChainResidueDetails
IASN55
IASN93
IASN221
D2ASN55
D2ASN93
D2ASN221

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28060820
ChainResidueDetails
IASN245
IASN350
D2ASN245
D2ASN350

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:28060820
ChainResidueDetails
ITHR352
D2THR352

221716

PDB entries from 2024-06-26

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