8HUE
Crystal structure of FGF2-M2 mutant - D28E/C78I/C96I/S137P
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Fibroblast growth factor 2 | polymer | 147 | 16611.1 | 3 | UniProt (P09038) Pfam (PF00167) | Homo sapiens (human) | FGF-2,Basic fibroblast growth factor,bFGF,Heparin-binding growth factor 2,HBGF-2 |
| 2 | D, E (D, E) | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose | branched | 982.8 | 2 | In PDB BIRD (PRD_900013) | |||
| 3 | F, G, H (A, B, C) | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, B, C: 10 - 155 (UniProt: P09038)
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
| Glu 28 | Asp 161 | engineered mutation |
| Ile 78 | Cys 211 | engineered mutation |
| Ile 96 | Cys 229 | engineered mutation |
| Pro 137 | Ser 270 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 49833.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1965.6 | |
| All* | Total formula weight | 51799.0 |
