8HUE

Crystal structure of FGF2-M2 mutant - D28E/C78I/C96I/S137P

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008083	molecular_function	growth factor activity
B	0008083	molecular_function	growth factor activity
C	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00247
Number of Residues	24
Details	HBGF_FGF HBGF/FGF family signature. GrLlAskivtd.ECfFfErlesnnY

Chain	Residue	Details
A	GLY89-TYR112

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASN36
B	ASN36
C	ASN36

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site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Important for interaction with integrin => ECO:0000269|PubMed:28302677

Chain	Residue	Details
A	LYS128
A	ARG129
A	LYS134
B	LYS128
B	ARG129
B	LYS134
C	LYS128
C	ARG129
C	LYS134

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by TEC => ECO:0000269|PubMed:20230531

Chain	Residue	Details
A	TYR82
B	TYR82
C	TYR82

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site_id	SWS_FT_FI4
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211

Chain	Residue	Details
A	LYS95
B	LYS95
C	LYS95

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