8HPY

Crystal structure of human LGI1-ADAM22 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Disintegrin and metalloproteinase domain-containing protein 22	polymer	486	53743.1	2	UniProt (Q9P0K1) Pfam (PF01421) Pfam (PF00200) Pfam (PF08516) Pfam (PF07974) In PDB	Homo sapiens (human)	ADAM 22,Metalloproteinase-disintegrin ADAM22-3,Metalloproteinase-like,disintegrin-like,and cysteine-rich protein 2
2	D, E	Leucine-rich glioma-inactivated protein 1	polymer	526	60616.6	2	UniProt (O95970) Pfam (PF03736) Pfam (PF13855) In PDB	Homo sapiens (human)	Epitempin-1
3	A, D, B, E	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG)
4	A, D, B, E	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)

Sequence modifications

D, E: 39 - 557 (UniProt: O95970)

PDB	External Database	Details
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	228719.4
Non-Polymers*	Number of molecules	20
	Total formula weight	2975.1
All*	Total formula weight	231694.5

*Water molecules are not included.