Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HPY

Crystal structure of human LGI1-ADAM22 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0007399	biological_process	nervous system development
D	0007411	biological_process	axon guidance
D	0030307	biological_process	positive regulation of cell growth
D	0030425	cellular_component	dendrite
D	0031175	biological_process	neuron projection development
D	0043083	cellular_component	synaptic cleft
D	0043194	cellular_component	axon initial segment
D	0045202	cellular_component	synapse
D	0050806	biological_process	positive regulation of synaptic transmission
D	0098978	cellular_component	glutamatergic synapse
D	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
E	0005102	molecular_function	signaling receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005794	cellular_component	Golgi apparatus
E	0007399	biological_process	nervous system development
E	0007411	biological_process	axon guidance
E	0030307	biological_process	positive regulation of cell growth
E	0030425	cellular_component	dendrite
E	0031175	biological_process	neuron projection development
E	0043083	cellular_component	synaptic cleft
E	0043194	cellular_component	axon initial segment
E	0045202	cellular_component	synapse
E	0050806	biological_process	positive regulation of synaptic transmission
E	0098978	cellular_component	glutamatergic synapse
E	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 804

Chain	Residue
A	GLU242
A	ASP325
A	CYS433
A	ASN436

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 805

Chain	Residue
A	ASP459
A	GLU446
A	ASN449
A	PHE451
A	GLU453
A	GLU456

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 806

Chain	Residue
A	ASP511
A	ILE512
A	GLU514
A	ASN526
A	ILE527

site_id	AC4
Number of Residues	5
Details	binding site for residue CA D 604

Chain	Residue
D	ASP334
D	GLU336
D	ASP381
D	VAL382
D	GLU383

site_id	AC5
Number of Residues	4
Details	binding site for residue CA B 804

Chain	Residue
B	GLU242
B	ASP325
B	CYS433
B	ASN436

site_id	AC6
Number of Residues	6
Details	binding site for residue CA B 805

Chain	Residue
B	GLU446
B	ASN449
B	PHE451
B	GLU453
B	GLU456
B	ASP459

site_id	AC7
Number of Residues	5
Details	binding site for residue CA B 806

Chain	Residue
B	ASP511
B	ILE512
B	GLU514
B	ASN526
B	ILE527

site_id	AC8
Number of Residues	5
Details	binding site for residue CA E 604

Chain	Residue
E	ASP334
E	GLU336
E	ASP381
E	VAL382
E	GLU383

site_id	AC9
Number of Residues	2
Details	binding site for Mono-Saccharide NAG A 801 bound to ASN A 519

Chain	Residue
A	SER517
A	ASN519

site_id	AD1
Number of Residues	1
Details	binding site for Mono-Saccharide NAG A 802 bound to ASN A 634

Chain	Residue
A	ASN634

site_id	AD2
Number of Residues	1
Details	binding site for Mono-Saccharide NAG A 803 bound to ASN A 675

Chain	Residue
A	ASN675

site_id	AD3
Number of Residues	1
Details	binding site for Mono-Saccharide NAG B 803 bound to ASN B 519

Chain	Residue
B	ASN519

site_id	AD4
Number of Residues	3
Details	binding site for Mono-Saccharide NAG B 802 bound to ASN B 634

Chain	Residue
B	THR606
B	ILE621
B	ASN634

site_id	AD5
Number of Residues	3
Details	binding site for Mono-Saccharide NAG B 801 bound to ASN B 675

Chain	Residue
B	SER673
B	PHE674
B	ASN675

site_id	AD6
Number of Residues	2
Details	binding site for Mono-Saccharide NAG D 601 bound to ASN D 192

Chain	Residue
D	GLY189
D	ASN192

site_id	AD7
Number of Residues	4
Details	binding site for Mono-Saccharide NAG D 602 bound to ASN D 277

Chain	Residue
D	LYS259
D	ILE261
D	ASN274
D	ASN277

site_id	AD8
Number of Residues	4
Details	binding site for Mono-Saccharide NAG D 603 bound to ASN D 422

Chain	Residue
D	THR421
D	ASN422
D	GLN423
D	THR424

site_id	AD9
Number of Residues	1
Details	binding site for Mono-Saccharide NAG E 603 bound to ASN E 192

Chain	Residue
E	ASN192

site_id	AE1
Number of Residues	3
Details	binding site for Mono-Saccharide NAG E 602 bound to ASN E 277

Chain	Residue
E	LYS259
E	ASP276
E	ASN277

site_id	AE2
Number of Residues	3
Details	binding site for Mono-Saccharide NAG E 601 bound to ASN E 422

Chain	Residue
E	ASN422
E	GLN423
E	THR424

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CvCnrHwiGSdC

Chain	Residue	Details
A	CYS700-CYS711

site_id	PS00427
Number of Residues	20
Details	DISINTEGRIN_1 Disintegrins signature. CsdGlCCk.KCkFqpmgtvCR

Chain	Residue	Details
A	CYS485-ARG504

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
D	ASN192
D	ASN277
D	ASN422
E	ASN192
E	ASN277
E	ASN422

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)