8HCR
Cryo-EM structure of the Mycobacterium tuberculosis cytochrome bcc:aa3 supercomplex and a novel inhibitor targeting subunit cytochrome cI
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, M | Cytochrome bc1 complex Rieske iron-sulfur subunit | polymer | 429 | 46976.5 | 2 | UniProt (A0A045GW18) Pfam (PF19297) Pfam (PF00355) UniProt (by SIFTS) (P9WH23) In PDB | Mycobacterium tuberculosis variant bovis BCG | Cytochrome bc1 reductase complex subunit QcrA,Rieske iron-sulfur protein |
2 | B, N | Cytochrome bc1 complex cytochrome b subunit | polymer | 573 | 63926.0 | 2 | UniProt (A0A0K2HYC0) Pfam (PF13631) UniProt (by SIFTS) (P9WP37) In PDB | Mycobacterium tuberculosis variant bovis BCG | Cytochrome bc1 reductase complex subunit QcrB |
3 | C, O | Cytochrome bc1 complex cytochrome c subunit | polymer | 280 | 29170.4 | 2 | UniProt (P9WP35) Pfam (PF00034) Pfam (PF13442) In PDB | Mycobacterium tuberculosis variant bovis BCG | Cytochrome bc1 reductase complex subunit QcrC,Ubiquinol--cytochrome c reductase cytochrome c subunit |
4 | E, Q | CYTOCHROME AA3 SUBUNIT CtaC | polymer | 363 | 40535.6 | 2 | Pfam (PF00116) UniProt (by SIFTS) (P9WP69) In PDB | Mycobacterium tuberculosis variant bovis BCG | |
5 | F, R | Probable cytochrome c oxidase subunit 1 | polymer | 573 | 63722.3 | 2 | UniProt (P9WP71) Pfam (PF00115) In PDB | Mycobacterium tuberculosis variant bovis BCG | Cytochrome aa3 subunit 1,Cytochrome c oxidase polypeptide I |
6 | G, S | Probable cytochrome c oxidase subunit 3 | polymer | 203 | 22435.0 | 2 | UniProt (P9WP67) Pfam (PF00510) In PDB | Mycobacterium tuberculosis variant bovis BCG | Cytochrome aa3 subunit 3,Cytochrome c oxidase polypeptide III |
7 | H, T | Cytochrome c oxidase polypeptide 4 | polymer | 139 | 14874.1 | 2 | UniProt (A0A0K2HXG0) Pfam (PF12270) UniProt (by SIFTS) (P9WP45) In PDB | Mycobacterium tuberculosis variant bovis BCG | Cytochrome aa3 subunit 4,Cytochrome c oxidase polypeptide IV |
8 | I, U | CYTOCHROME AA3 SUBUNIT CtaJ | polymer | 79 | 8408.6 | 2 | UniProt (by SIFTS) (I6YDH3) In PDB | Mycobacterium tuberculosis variant bovis BCG | |
9 | J, V | DUF5130 domain-containing protein | polymer | 155 | 15982.0 | 2 | UniProt (A0A7U4BVZ0) Pfam (PF17174) UniProt (by SIFTS) (P9WLA7) In PDB | Mycobacterium tuberculosis variant bovis BCG | |
10 | A, M | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
11 | N, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
12 | O, C | HEME C | non-polymer | 618.5 | 4 | Chemie (HEC) | |||
13 | R, F | HEME-A | non-polymer | 852.8 | 4 | Chemie (HEA) |
Sequence modifications
B, N: 1 - 549 (UniProt: A0A0K2HYC0)
PDB | External Database | Details |
---|---|---|
Gly 550 | - | expression tag |
Gly 551 | - | expression tag |
Gly 552 | - | expression tag |
Gly 553 | - | expression tag |
Glu 554 | - | expression tag |
Asn 555 | - | expression tag |
Leu 556 | - | expression tag |
Tyr 557 | - | expression tag |
Phe 558 | - | expression tag |
Gln 559 | - | expression tag |
Asp 560 | - | expression tag |
Tyr 561 | - | expression tag |
Lys 562 | - | expression tag |
Asp 563 | - | expression tag |
Asp 564 | - | expression tag |
Asp 565 | - | expression tag |
Asp 566 | - | expression tag |
Lys 567 | - | expression tag |
His 568 | - | expression tag |
His 569 | - | expression tag |
His 570 | - | expression tag |
His 571 | - | expression tag |
His 572 | - | expression tag |
His 573 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 18 |
Total formula weight | 612061.1 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 8702.9 | |
All* | Total formula weight | 620764.1 |