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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HCR

Cryo-EM structure of the Mycobacterium tuberculosis cytochrome bcc:aa3 supercomplex and a novel inhibitor targeting subunit cytochrome cI

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005886cellular_componentplasma membrane
A0009274cellular_componentpeptidoglycan-based cell wall
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0046872molecular_functionmetal ion binding
A0051536molecular_functioniron-sulfur cluster binding
A0051537molecular_function2 iron, 2 sulfur cluster binding
B0005886cellular_componentplasma membrane
B0008121molecular_functionquinol-cytochrome-c reductase activity
B0009055molecular_functionelectron transfer activity
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0022904biological_processrespiratory electron transport chain
B0046872molecular_functionmetal ion binding
B1902600biological_processproton transmembrane transport
C0004129molecular_functioncytochrome-c oxidase activity
C0005506molecular_functioniron ion binding
C0005886cellular_componentplasma membrane
C0008121molecular_functionquinol-cytochrome-c reductase activity
C0009055molecular_functionelectron transfer activity
C0016020cellular_componentmembrane
C0020037molecular_functionheme binding
C0046872molecular_functionmetal ion binding
C1902600biological_processproton transmembrane transport
E0004129molecular_functioncytochrome-c oxidase activity
E0005507molecular_functioncopper ion binding
E0016020cellular_componentmembrane
F0004129molecular_functioncytochrome-c oxidase activity
F0005886cellular_componentplasma membrane
F0006119biological_processoxidative phosphorylation
F0009060biological_processaerobic respiration
F0015990biological_processelectron transport coupled proton transport
F0016020cellular_componentmembrane
F0020037molecular_functionheme binding
F0022904biological_processrespiratory electron transport chain
F0046872molecular_functionmetal ion binding
G0004129molecular_functioncytochrome-c oxidase activity
G0005886cellular_componentplasma membrane
G0009055molecular_functionelectron transfer activity
G0009060biological_processaerobic respiration
G0016020cellular_componentmembrane
G0019646biological_processaerobic electron transport chain
G0022904biological_processrespiratory electron transport chain
G1902600biological_processproton transmembrane transport
H0004129molecular_functioncytochrome-c oxidase activity
H0005886cellular_componentplasma membrane
H0016020cellular_componentmembrane
H0022900biological_processelectron transport chain
H1902600biological_processproton transmembrane transport
I0016020cellular_componentmembrane
J0005886cellular_componentplasma membrane
M0004497molecular_functionmonooxygenase activity
M0005886cellular_componentplasma membrane
M0009274cellular_componentpeptidoglycan-based cell wall
M0016020cellular_componentmembrane
M0016491molecular_functionoxidoreductase activity
M0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
M0046872molecular_functionmetal ion binding
M0051536molecular_functioniron-sulfur cluster binding
M0051537molecular_function2 iron, 2 sulfur cluster binding
N0005886cellular_componentplasma membrane
N0008121molecular_functionquinol-cytochrome-c reductase activity
N0009055molecular_functionelectron transfer activity
N0016020cellular_componentmembrane
N0016491molecular_functionoxidoreductase activity
N0022904biological_processrespiratory electron transport chain
N0046872molecular_functionmetal ion binding
N1902600biological_processproton transmembrane transport
O0004129molecular_functioncytochrome-c oxidase activity
O0005506molecular_functioniron ion binding
O0005886cellular_componentplasma membrane
O0008121molecular_functionquinol-cytochrome-c reductase activity
O0009055molecular_functionelectron transfer activity
O0016020cellular_componentmembrane
O0020037molecular_functionheme binding
O0046872molecular_functionmetal ion binding
O1902600biological_processproton transmembrane transport
Q0004129molecular_functioncytochrome-c oxidase activity
Q0005507molecular_functioncopper ion binding
Q0016020cellular_componentmembrane
R0004129molecular_functioncytochrome-c oxidase activity
R0005886cellular_componentplasma membrane
R0006119biological_processoxidative phosphorylation
R0009060biological_processaerobic respiration
R0015990biological_processelectron transport coupled proton transport
R0016020cellular_componentmembrane
R0020037molecular_functionheme binding
R0022904biological_processrespiratory electron transport chain
R0046872molecular_functionmetal ion binding
S0004129molecular_functioncytochrome-c oxidase activity
S0005886cellular_componentplasma membrane
S0009055molecular_functionelectron transfer activity
S0009060biological_processaerobic respiration
S0016020cellular_componentmembrane
S0019646biological_processaerobic electron transport chain
S0022904biological_processrespiratory electron transport chain
S1902600biological_processproton transmembrane transport
T0004129molecular_functioncytochrome-c oxidase activity
T0005886cellular_componentplasma membrane
T0016020cellular_componentmembrane
T0022900biological_processelectron transport chain
T1902600biological_processproton transmembrane transport
U0016020cellular_componentmembrane
V0005886cellular_componentplasma membrane
Functional Information from PROSITE/UniProt
site_idPS00077
Number of Residues55
DetailsCOX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiialpffgivseifpvfsrkpifgyttlvyatlsiaalsvavwa..HH
ChainResidueDetails
FTRP260-HIS314
site_idPS00078
Number of Residues55
DetailsCOX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHafwvpeflfkrdvmpnpvannsvnvfqieeiiktgafvghCaemCgtyHsmM
ChainResidueDetails
EVAL230-MET284
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues1080
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues188
DetailsDomain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues360
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00968","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00968","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues156
DetailsDomain: {"description":"Cytochrome c 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsBinding site: {"description":"covalent","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsBinding site: {"description":"axial binding residue","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsCross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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