Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HCR

Cryo-EM structure of the Mycobacterium tuberculosis cytochrome bcc:aa3 supercomplex and a novel inhibitor targeting subunit cytochrome cI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0005886	cellular_component	plasma membrane
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022904	biological_process	respiratory electron transport chain
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0005506	molecular_function	iron ion binding
C	0005886	cellular_component	plasma membrane
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
E	0004129	molecular_function	cytochrome-c oxidase activity
E	0005507	molecular_function	copper ion binding
E	0016020	cellular_component	membrane
F	0004129	molecular_function	cytochrome-c oxidase activity
F	0005886	cellular_component	plasma membrane
F	0006119	biological_process	oxidative phosphorylation
F	0009060	biological_process	aerobic respiration
F	0015990	biological_process	electron transport coupled proton transport
F	0016020	cellular_component	membrane
F	0020037	molecular_function	heme binding
F	0022904	biological_process	respiratory electron transport chain
F	0046872	molecular_function	metal ion binding
G	0004129	molecular_function	cytochrome-c oxidase activity
G	0005886	cellular_component	plasma membrane
G	0009055	molecular_function	electron transfer activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0019646	biological_process	aerobic electron transport chain
G	0022904	biological_process	respiratory electron transport chain
G	1902600	biological_process	proton transmembrane transport
H	0004129	molecular_function	cytochrome-c oxidase activity
H	0005886	cellular_component	plasma membrane
H	0016020	cellular_component	membrane
H	0022900	biological_process	electron transport chain
H	1902600	biological_process	proton transmembrane transport
I	0016020	cellular_component	membrane
J	0005886	cellular_component	plasma membrane
M	0005886	cellular_component	plasma membrane
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0016491	molecular_function	oxidoreductase activity
M	0046872	molecular_function	metal ion binding
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
N	0005886	cellular_component	plasma membrane
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0046872	molecular_function	metal ion binding
N	1902600	biological_process	proton transmembrane transport
O	0005506	molecular_function	iron ion binding
O	0005886	cellular_component	plasma membrane
O	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
O	0009055	molecular_function	electron transfer activity
O	0016020	cellular_component	membrane
O	0020037	molecular_function	heme binding
O	0046872	molecular_function	metal ion binding
O	1902600	biological_process	proton transmembrane transport
Q	0004129	molecular_function	cytochrome-c oxidase activity
Q	0005507	molecular_function	copper ion binding
Q	0016020	cellular_component	membrane
R	0004129	molecular_function	cytochrome-c oxidase activity
R	0005886	cellular_component	plasma membrane
R	0006119	biological_process	oxidative phosphorylation
R	0009060	biological_process	aerobic respiration
R	0015990	biological_process	electron transport coupled proton transport
R	0016020	cellular_component	membrane
R	0020037	molecular_function	heme binding
R	0022904	biological_process	respiratory electron transport chain
R	0046872	molecular_function	metal ion binding
S	0004129	molecular_function	cytochrome-c oxidase activity
S	0005886	cellular_component	plasma membrane
S	0009055	molecular_function	electron transfer activity
S	0009060	biological_process	aerobic respiration
S	0016020	cellular_component	membrane
S	0019646	biological_process	aerobic electron transport chain
S	0022904	biological_process	respiratory electron transport chain
S	1902600	biological_process	proton transmembrane transport
T	0004129	molecular_function	cytochrome-c oxidase activity
T	0005886	cellular_component	plasma membrane
T	0016020	cellular_component	membrane
T	0022900	biological_process	electron transport chain
T	1902600	biological_process	proton transmembrane transport
U	0016020	cellular_component	membrane
V	0005886	cellular_component	plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiialpffgivseifpvfsrkpifgyttlvyatlsiaalsvavwa..HH

Chain	Residue	Details
F	TRP260-HIS314

site_id	PS00078
Number of Residues	55
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHafwvpeflfkrdvmpnpvannsvnvfqieeiiktgafvghCaemCgtyHsmM

Chain	Residue	Details
E	VAL230-MET284

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
H	PHE10-ALA30
N	PHE45-LEU65
N	ALA118-PHE138
N	TRP146-LEU166
N	VAL189-ILE209
N	ILE217-PHE237
N	SER266-ILE286
N	PRO335-LEU355
N	ILE381-ILE401
N	ILE418-LEU438
R	ILE290-VAL310
H	TRP36-PHE56
R	MET315-VAL335
R	MET359-LEU379
R	PHE398-PHE418
R	LEU433-GLY453
R	VAL476-PHE496
H	GLY78-SER98
H	VAL101-ILE121
T	PHE10-ALA30
T	TRP36-PHE56
T	GLY78-SER98
T	VAL101-ILE121
B	ILE418-LEU438

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
E	HIS232
E	CYS273
E	CYS277
E	HIS281
Q	HIS232
Q	CYS273
Q	CYS277
Q	HIS281

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
F	HIS264
F	TYR268
F	HIS313
F	HIS314
R	HIS264
R	TYR268
R	HIS313
R	HIS314

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylthreonine => ECO:0007744\|PubMed:21969609

Chain	Residue	Details
F	THR2
R	THR2

site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250

Chain	Residue	Details
F	HIS264
F	TYR268
R	HIS264
R	TYR268

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)