8GUW
Structure of Aurora Kinase A in complex with activator peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Peptide from Centrosomal protein of 192 kDa,Aurora kinase A | polymer | 304 | 35113.9 | 3 | UniProt (Q8TEP8) UniProt (O14965) Pfam (PF25763) Pfam (PF00069) | Homo sapiens (human) | Cep192,Cep192/SPD-2,Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | D, E, F (A, B, C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A, B, C: 101 - 122 (UniProt: Q8TEP8)
A, B, C: 123 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 100 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 290 | Cys 290 | engineered mutation |
| Ala 393 | Cys 393 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 105341.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1281.6 | |
| All* | Total formula weight | 106623.3 |
