8GUW

Structure of Aurora Kinase A in complex with activator peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Peptide from Centrosomal protein of 192 kDa,Aurora kinase A	polymer	304	35113.9	3	UniProt (Q8TEP8) UniProt (O14965) Pfam (PF00069) In PDB	Homo sapiens (human)	Cep192,Cep192/SPD-2,Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
2	A, B, C	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	3	Chemie (ADP)
3		water	water		18.0	73	Chemie (HOH)

Sequence modifications

A, B, C: 101 - 122 (UniProt: Q8TEP8)

PDB	External Database	Details
Gly 100	-	expression tag

A, B, C: 123 - 403 (UniProt: O14965)

PDB	External Database	Details
Ala 290	Cys 290	engineered mutation
Ala 393	Cys 393	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	105341.7
Non-Polymers*	Number of molecules	3
	Total formula weight	1281.6
All*	Total formula weight	106623.3

*Water molecules are not included.