8GRQ
Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3 | polymer | 98 | 11530.4 | 2 | UniProt (A0A653DHJ5) Pfam (PF00125) UniProt (by SIFTS) (Q71DI3) | Homo sapiens (human) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 80 | 9123.7 | 2 | UniProt (A0A0P9AXL3) Pfam (PF15511) UniProt (by SIFTS) (P62805) | Homo sapiens (human) | |
| 3 | C, G (C, G) | Histone H2A type 1-H | polymer | 110 | 12066.1 | 2 | UniProt (Q8CGP6) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P04908) | Homo sapiens (human) | H2A-clustered histone 12 |
| 4 | D, H (D, H) | H2B | polymer | 188 | 20938.0 | 2 | Pfam (PF00125) UniProt (by SIFTS) (O60814) | Homo sapiens | |
| 5 | I (I) | DNA (147-MER) | polymer | 147 | 45604.0 | 1 | Homo sapiens | ||
| 6 | J (J) | DNA (147-MER) | polymer | 147 | 45145.8 | 1 | Homo sapiens | ||
| 7 | K (K) | Breast cancer type 1 susceptibility protein | polymer | 92 | 10626.7 | 1 | UniProt (P38398) Pfam (PF00097) | Homo sapiens (human) | RING finger protein 53,RING-type E3 ubiquitin transferase BRCA1 |
| 8 | L (M) | BRCA1-associated RING domain protein 1 | polymer | 92 | 10348.1 | 1 | UniProt (Q99728) Pfam (PF14835) | Homo sapiens (human) | BARD-1,RING-type E3 ubiquitin transferase BARD1 |
| 9 | M (N) | Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a | polymer | 147 | 16657.9 | 1 | Pfam (PF00179) UniProt (by SIFTS) (P61077) | Homo sapiens (human) | |
| 10 | N, O, P, Q (K, M) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 235699.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 235960.7 |
