8GJU
Crystal structure of human methylmalonyl-CoA mutase (MMUT) in complex with methylmalonic acidemia type A protein (MMAA), coenzyme A, and GDP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, F, A, B | Methylmalonic aciduria type A protein, mitochondrial | polymer | 349 | 38718.9 | 4 | UniProt (Q8IVH4) Pfam (PF03308) In PDB | Homo sapiens (human) | |
2 | J, K, L, H | Methylmalonyl-CoA mutase, mitochondrial | polymer | 748 | 83010.0 | 4 | UniProt (A0A2S1PH20) Pfam (PF01642) Pfam (PF02310) UniProt (by SIFTS) (P22033) In PDB | Homo sapiens (human) | Methylmalonyl-CoA isomerase |
3 | D, F, A, B | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) | |||
4 | D, F, A, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | J, K, L, H | COENZYME A | non-polymer | 767.5 | 4 | Chemie (COA) | |||
6 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
D, F, A, B: 72 - 418 (UniProt: Q8IVH4)
J, K, L, H: 12 - 750 (UniProt: A0A2S1PH20)
PDB | External Database | Details |
---|---|---|
Ser 70 | - | expression tag |
Met 71 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 11 | - | initiating methionine |
Thr 499 | Ala 499 | conflict |
Ala 751 | - | expression tag |
Glu 752 | - | expression tag |
Asn 753 | - | expression tag |
Leu 754 | - | expression tag |
Tyr 755 | - | expression tag |
Phe 756 | - | expression tag |
Gln 757 | - | expression tag |
Ser 758 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 486915.3 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4940.2 | |
All* | Total formula weight | 491855.5 |